Gene name: LEU4
Reference locus (S288C): YNL104C
Gene biotype: protein_coding
Description: Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
Top 10 interactors (score): LEU9 (0.999); ILV3 (0.997); LEU1 (0.995); ILV2 (0.992); BAT2 (0.979); ILV6 (0.968); BAT1 (0.963); LYS21 (0.948); ERG10 (0.94); LYS20 (0.939); ACS2 (0.93); DAL7 (0.929); MLS1 (0.925); ACS1 (0.921); ILV5 (0.919); LEU5 (0.918); ACC1 (0.917); HFA1 (0.913); LAT1 (0.911); ACH1 (0.901)
Homologues (species, bitscore): MAML-4 (Arabidopsis thaliana, 125.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:418539-420398:- | gene-YNL104C_AKU4011 | rna-NM_001182942.1_AKU4011 | cds-NP_014295.1_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:322549-324408:- | gene-YNL104C_BG1 | rna-NM_001182942.1_BG1 | cds-NP_014295.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:429272-431131:- | gene-YNL104C_Bruggeman | rna-NM_001182942.1_Bruggeman | cds-NP_014295.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:472315-474174:- | gene-YNL104C_CAT1 | rna-NM_001182942.1_CAT1 | cds-NP_014295.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:419154-421013:- | gene-YNL104C_CBS1585 | rna-NM_001182942.1_CBS1585 | cds-NP_014295.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:487578-489437:- | gene-YNL104C_CBS436 | rna-NM_001182942.1_CBS436 | cds-NP_014295.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:414627-416486:- | gene-YNL104C_CBS6412 | rna-NM_001182942.1_CBS6412 | cds-NP_014295.1_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:415630-417489:- | gene-YNL104C_CBS6413 | rna-NM_001182942.1_CBS6413 | cds-NP_014295.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:418746-420605:- | gene-YNL104C_CENPK1137D | rna-NM_001182942.1_CENPK1137D | cds-NP_014295.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:415558-417417:- | gene-YNL104C_EthanolRed | rna-NM_001182942.1_EthanolRed | cds-NP_014295.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:411454-413313:- | gene-YNL104C_FaliES1 | rna-NM_001182942.1_FaliES1 | cds-NP_014295.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000140.1:1-954:- | gene-YNL104C_JAY291 | rna-NM_001182942.1_JAY291 | cds-NP_014295.1_JAY291 | 51.2 | 51.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:425442-427301:- | gene-YNL104C_MUCL30387 | rna-NM_001182942.1_MUCL30387 | cds-NP_014295.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:460832-462691:- | gene-YNL104C_MUCL30388 | rna-NM_001182942.1_MUCL30388 | cds-NP_014295.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:416547-418406:- | gene-YNL104C_MUCL39482 | rna-NM_001182942.1_MUCL39482 | cds-NP_014295.1_MUCL39482 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:420582-422441:- | gene-YNL104C_MUCL42920 | rna-NM_001182942.1_MUCL42920 | cds-NP_014295.1_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:424864-426723:- | gene-YNL104C_NCIM3186 | rna-NM_001182942.1_NCIM3186 | cds-NP_014295.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:418684-420543:- | gene-YNL104C_NCYC1407 | rna-NM_001182942.1_NCYC1407 | cds-NP_014295.1_NCYC1407 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:417605-419464:- | gene-YNL104C_PE2H3 | rna-NM_001182942.1_PE2H3 | cds-NP_014295.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:417011-418870:- | gene-YNL104C_PE2H4 | rna-NM_001182942.1_PE2H4 | cds-NP_014295.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:424895-426754:- | gene-YNL104C_S288C | rna-NM_001182942.1_S288C | cds-NP_014295.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:9855-11714:- | gene-YNL104C_SA1 | rna-NM_001182942.1_SA1 | cds-NP_014295.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:412326-414185:- | gene-YNL104C_ThermosaccDry | rna-NM_001182942.1_ThermosaccDry | cds-NP_014295.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:431029-432888:- | gene-YNL104C_VR1 | rna-NM_001182942.1_VR1 | cds-NP_014295.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:322145-324004:- | gene-YNL104C_ZTW1 | rna-NM_001182942.1_ZTW1 | cds-NP_014295.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:423216-425075:- | gene-YNL104C_Sparadoxus | rna-NM_001182942.1_Sparadoxus | cds-NP_014295.1_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |