Gene name: LEU3
Reference locus (S288C): YLR451W
Gene biotype: protein_coding
Description: Regulatory protein LEU3; Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
Top 10 interactors (score): LEU1 (0.901); GCN4 (0.9); LEU4 (0.866); LEU2 (0.857); DAL81 (0.815); YLR278C (0.788); MOT3 (0.787); BAP2 (0.783); ILV5 (0.78); ILV2 (0.78); PUT3 (0.779); ILV3 (0.749); PPR1 (0.741); FSF1 (0.736); WAR1 (0.718); LYS14 (0.717); UGA3 (0.714); CBF1 (0.697); ARG81 (0.695); LEU9 (0.692)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:974384-977044:+ | gene-YLR451W_AKU4011 | rna-NM_001182339.3_AKU4011 | cds-NP_013556.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:206820-209480:+ | gene-YLR451W_BG1 | rna-NM_001182339.3_BG1 | cds-NP_013556.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:1012677-1015337:+ | gene-YLR451W_Bruggeman | rna-NM_001182339.3_Bruggeman | cds-NP_013556.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:1008685-1011345:+ | gene-YLR451W_CAT1 | rna-NM_001182339.3_CAT1 | cds-NP_013556.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:1009974-1012634:+ | gene-YLR451W_CBS1585 | rna-NM_001182339.3_CBS1585 | cds-NP_013556.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:999299-1001959:+ | gene-YLR451W_CBS436 | rna-NM_001182339.3_CBS436 | cds-NP_013556.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:1046003-1048663:+ | gene-YLR451W_CBS6412 | rna-NM_001182339.3_CBS6412 | cds-NP_013556.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:1010744-1013404:+ | gene-YLR451W_CBS6413 | rna-NM_001182339.3_CBS6413 | cds-NP_013556.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:1020699-1023379:+ | gene-YLR451W_CENPK1137D | rna-NM_001182339.3_CENPK1137D | cds-NP_013556.3_CENPK1137D | 98.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:967400-970060:+ | gene-YLR451W_EthanolRed | rna-NM_001182339.3_EthanolRed | cds-NP_013556.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:1002671-1005331:+ | gene-YLR451W_FaliES1 | rna-NM_001182339.3_FaliES1 | cds-NP_013556.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000194.1:13346-16006:- | gene-YLR451W_JAY291 | rna-NM_001182339.3_JAY291 | cds-NP_013556.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:1011535-1014195:+ | gene-YLR451W_MUCL30387 | rna-NM_001182339.3_MUCL30387 | cds-NP_013556.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:1021368-1024028:+ | gene-YLR451W_MUCL30388 | rna-NM_001182339.3_MUCL30388 | cds-NP_013556.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:1011208-1013868:+ | gene-YLR451W_MUCL39482 | rna-NM_001182339.3_MUCL39482 | cds-NP_013556.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:1011659-1014319:+ | gene-YLR451W_MUCL42920 | rna-NM_001182339.3_MUCL42920 | cds-NP_013556.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:1036067-1038727:+ | gene-YLR451W_NCIM3186 | rna-NM_001182339.3_NCIM3186 | cds-NP_013556.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:1020645-1023305:+ | gene-YLR451W_NCYC1407 | rna-NM_001182339.3_NCYC1407 | cds-NP_013556.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:1007089-1009749:+ | gene-YLR451W_PE2H3 | rna-NM_001182339.3_PE2H3 | cds-NP_013556.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:1006833-1009493:+ | gene-YLR451W_PE2H4 | rna-NM_001182339.3_PE2H4 | cds-NP_013556.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:1036093-1038753:+ | gene-YLR451W_S288C | rna-NM_001182339.3_S288C | cds-NP_013556.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:21109-23769:- | gene-YLR451W_SA1 | rna-NM_001182339.3_SA1 | cds-NP_013556.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:1005749-1008409:+ | gene-YLR451W_ThermosaccDry | rna-NM_001182339.3_ThermosaccDry | cds-NP_013556.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:1012170-1014830:+ | gene-YLR451W_VR1 | rna-NM_001182339.3_VR1 | cds-NP_013556.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:336003-338662:+ | gene-YLR451W_ZTW1 | rna-NM_001182339.3_ZTW1 | cds-NP_013556.3_ZTW1 | 99.7 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:984944-987607:+ | gene-YLR451W_Sparadoxus | rna-NM_001182339.3_Sparadoxus | cds-NP_013556.3_Sparadoxus | 91.0 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |