Gene name: LEU2
Reference locus (S288C): YCL018W
Gene biotype: protein_coding
Description: Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; Belongs to the isocitrate and isopropylmalate dehydrogenases family
Top 10 interactors (score): LEU1 (0.999); ILV2 (0.993); URA3 (0.982); ILV1 (0.979); ILV6 (0.978); TRP1 (0.978); HIS3 (0.977); LYS4 (0.974); CHA1 (0.973); ADE2 (0.972); LYS2 (0.969); CAN1 (0.946); HIS4 (0.945); ILV5 (0.94); HIS1 (0.929); GAL1 (0.923); MET17 (0.917); ADE1 (0.912); BAP2 (0.907); TRP5 (0.897)
Homologues (species, bitscore): IDH3A (Homo sapiens, 105.9); Idh3a (Mus musculus, 107.5); idh3a (Danio rerio, 114.0); idh3a (Xenopus tropicalis, 119.0); l(1)G0156 (Drosophila melanogaster, 123.2); idha-1 (Caenorhabditis elegans, 114.8); IMD2 (Arabidopsis thaliana, 292.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:86033-87127:+ | gene-YCL018W_AKU4011 | rna-NM_001178665.1_AKU4011 | cds-NP_009911.2_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000178.1:58913-60007:- | gene-YCL018W_BG1 | rna-NM_001178665.1_BG1 | cds-NP_009911.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:80625-81719:+ | gene-YCL018W_Bruggeman | rna-NM_001178665.1_Bruggeman | cds-NP_009911.2_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:85837-86931:+ | gene-YCL018W_CAT1 | rna-NM_001178665.1_CAT1 | cds-NP_009911.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:86682-87776:+ | gene-YCL018W_CBS1585 | rna-NM_001178665.1_CBS1585 | cds-NP_009911.2_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:91604-92698:+ | gene-YCL018W_CBS436 | rna-NM_001178665.1_CBS436 | cds-NP_009911.2_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:74140-75234:+ | gene-YCL018W_CBS6412 | rna-NM_001178665.1_CBS6412 | cds-NP_009911.2_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:85989-87083:+ | gene-YCL018W_CBS6413 | rna-NM_001178665.1_CBS6413 | cds-NP_009911.2_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:90789-91885:+ | gene-YCL018W_CENPK1137D | rna-NM_001178665.1_CENPK1137D | cds-NP_009911.2_CENPK1137D | 99.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:84051-85145:+ | gene-YCL018W_EthanolRed | rna-NM_001178665.1_EthanolRed | cds-NP_009911.2_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:86341-87435:+ | gene-YCL018W_FaliES1 | rna-NM_001178665.1_FaliES1 | cds-NP_009911.2_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000126.1:517-1611:+ | gene-YCL018W_JAY291 | rna-NM_001178665.1_JAY291 | cds-NP_009911.2_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:79061-80155:+ | gene-YCL018W_MUCL30387 | rna-NM_001178665.1_MUCL30387 | cds-NP_009911.2_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:78615-79709:+ | gene-YCL018W_MUCL30388 | rna-NM_001178665.1_MUCL30388 | cds-NP_009911.2_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:87098-88192:+ | gene-YCL018W_MUCL39482 | rna-NM_001178665.1_MUCL39482 | cds-NP_009911.2_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:82335-83429:+ | gene-YCL018W_MUCL42920 | rna-NM_001178665.1_MUCL42920 | cds-NP_009911.2_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:90956-92050:+ | gene-YCL018W_NCIM3186 | rna-NM_001178665.1_NCIM3186 | cds-NP_009911.2_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:87581-88675:+ | gene-YCL018W_NCYC1407 | rna-NM_001178665.1_NCYC1407 | cds-NP_009911.2_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:91753-92847:+ | gene-YCL018W_PE2H3 | rna-NM_001178665.1_PE2H3 | cds-NP_009911.2_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:91710-92804:+ | gene-YCL018W_PE2H4 | rna-NM_001178665.1_PE2H4 | cds-NP_009911.2_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:91324-92418:+ | gene-YCL018W_S288C | rna-NM_001178665.1_S288C | cds-NP_009911.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000073.1:58922-60016:- | gene-YCL018W_SA1 | rna-NM_001178665.1_SA1 | cds-NP_009911.2_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:86915-88009:+ | gene-YCL018W_ThermosaccDry | rna-NM_001178665.1_ThermosaccDry | cds-NP_009911.2_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:97557-98651:+ | gene-YCL018W_VR1 | rna-NM_001178665.1_VR1 | cds-NP_009911.2_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:85857-86951:+ | gene-YCL018W_ZTW1 | rna-NM_001178665.1_ZTW1 | cds-NP_009911.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:116134-117228:+ | gene-YCL018W_Sparadoxus | rna-NM_001178665.1_Sparadoxus | cds-NP_009911.2_Sparadoxus | 94.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |