Gene name: LEU1
Reference locus (S288C): YGL009C
Gene biotype: protein_coding
Description: 3-isopropylmalate dehydratase; Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway; Belongs to the aconitase/IPM isomerase family
Top 10 interactors (score): LEU2 (0.999); LEU9 (0.995); LEU4 (0.995); ILV3 (0.977); TRP5 (0.953); BAT1 (0.952); OAC1 (0.951); ILV2 (0.946); ILV5 (0.932); LYS4 (0.913); ATM1 (0.91); LEU3 (0.901); LYS2 (0.885); LYS21 (0.858); ARG5,6 (0.85); CDC19 (0.849); TRP3 (0.84); IDH2 (0.839); MAE1 (0.835); PYK2 (0.833)
Homologues (species, bitscore): ACO2 (Homo sapiens, 139.4); Aco2 (Mus musculus, 140.2); aco2 (Danio rerio, 133.7); aco2 (Xenopus tropicalis, 126.7); Acon (Drosophila melanogaster, 146.7); aco-2 (Caenorhabditis elegans, 146.4); IIL1 (Arabidopsis thaliana, 191.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:478364-480703:- | gene-YGL009C_AKU4011 | rna-NM_001180874.1_AKU4011 | cds-NP_011506.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:95407-97746:+ | gene-YGL009C_BG1 | rna-NM_001180874.1_BG1 | cds-NP_011506.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:479333-481672:- | gene-YGL009C_Bruggeman | rna-NM_001180874.1_Bruggeman | cds-NP_011506.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:477626-479965:- | gene-YGL009C_CAT1 | rna-NM_001180874.1_CAT1 | cds-NP_011506.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:479835-482174:- | gene-YGL009C_CBS1585 | rna-NM_001180874.1_CBS1585 | cds-NP_011506.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:474215-476554:- | gene-YGL009C_CBS436 | rna-NM_001180874.1_CBS436 | cds-NP_011506.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:472450-474789:- | gene-YGL009C_CBS6412 | rna-NM_001180874.1_CBS6412 | cds-NP_011506.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:476506-478845:- | gene-YGL009C_CBS6413 | rna-NM_001180874.1_CBS6413 | cds-NP_011506.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:476134-478473:- | gene-YGL009C_CENPK1137D | rna-NM_001180874.1_CENPK1137D | cds-NP_011506.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:466731-469070:- | gene-YGL009C_EthanolRed | rna-NM_001180874.1_EthanolRed | cds-NP_011506.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:469987-472326:- | gene-YGL009C_FaliES1 | rna-NM_001180874.1_FaliES1 | cds-NP_011506.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000020.1:8622-10961:- | gene-YGL009C_JAY291 | rna-NM_001180874.1_JAY291 | cds-NP_011506.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:476556-478895:- | gene-YGL009C_MUCL30387 | rna-NM_001180874.1_MUCL30387 | cds-NP_011506.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:479105-481444:- | gene-YGL009C_MUCL30388 | rna-NM_001180874.1_MUCL30388 | cds-NP_011506.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:475674-478013:- | gene-YGL009C_MUCL39482 | rna-NM_001180874.1_MUCL39482 | cds-NP_011506.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:485111-487450:- | gene-YGL009C_MUCL42920 | rna-NM_001180874.1_MUCL42920 | cds-NP_011506.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:476313-478652:- | gene-YGL009C_NCIM3186 | rna-NM_001180874.1_NCIM3186 | cds-NP_011506.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:469696-472035:- | gene-YGL009C_NCYC1407 | rna-NM_001180874.1_NCYC1407 | cds-NP_011506.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:472390-474729:- | gene-YGL009C_PE2H3 | rna-NM_001180874.1_PE2H3 | cds-NP_011506.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:477440-479779:- | gene-YGL009C_PE2H4 | rna-NM_001180874.1_PE2H4 | cds-NP_011506.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:476313-478652:- | gene-YGL009C_S288C | rna-NM_001180874.1_S288C | cds-NP_011506.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000021.1:76932-79271:+ | gene-YGL009C_SA1 | rna-NM_001180874.1_SA1 | cds-NP_011506.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:489312-491651:- | gene-YGL009C_ThermosaccDry | rna-NM_001180874.1_ThermosaccDry | cds-NP_011506.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:579397-581736:- | gene-YGL009C_VR1 | rna-NM_001180874.1_VR1 | cds-NP_011506.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:467916-470255:- | gene-YGL009C_ZTW1 | rna-NM_001180874.1_ZTW1 | cds-NP_011506.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:477459-479797:- | gene-YGL009C_Sparadoxus | rna-NM_001180874.1_Sparadoxus | cds-NP_011506.1_Sparadoxus | 92.3 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |