Gene name: LEM3
Reference locus (S288C): YNL323W
Gene biotype: protein_coding
Description: Alkylphosphocholine resistance protein LEM3; Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p
Top 10 interactors (score): DNF1 (0.999); DNF2 (0.999); DRS2 (0.997); DNF3 (0.964); NEO1 (0.953); CDC50 (0.909); RDI1 (0.781); FPK1 (0.773); KIN82 (0.731); TAT2 (0.713); CHO1 (0.674); RGA1 (0.618); ELO3 (0.593); RCY1 (0.585); YOR1 (0.572); CNB1 (0.559); TSC10 (0.558); RIM21 (0.553); ERG6 (0.544); CDC42 (0.538)
Homologues (species, bitscore): TMEM30A (Homo sapiens, 159.8); Tmem30a (Mus musculus, 156.8); tmem30ab (Danio rerio, 158.7); tmem30a (Xenopus tropicalis, 151.8); CG9947 (Drosophila melanogaster, 171.8); chat-1 (Caenorhabditis elegans, 144.4); ALIS5 (Arabidopsis thaliana, 165.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:25746-26990:+ | gene-YNL323W_AKU4011 | rna-NM_001183161.1_AKU4011 | cds-NP_014076.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:63653-64897:- | gene-YNL323W_BG1 | rna-NM_001183161.1_BG1 | cds-NP_014076.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:35083-36327:+ | gene-YNL323W_Bruggeman | rna-NM_001183161.1_Bruggeman | cds-NP_014076.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:37709-38953:+ | gene-YNL323W_CAT1 | rna-NM_001183161.1_CAT1 | cds-NP_014076.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:26080-27324:+ | gene-YNL323W_CBS1585 | rna-NM_001183161.1_CBS1585 | cds-NP_014076.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:26570-27814:+ | gene-YNL323W_CBS436 | rna-NM_001183161.1_CBS436 | cds-NP_014076.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:22737-23981:+ | gene-YNL323W_CBS6412 | rna-NM_001183161.1_CBS6412 | cds-NP_014076.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:22926-24170:+ | gene-YNL323W_CBS6413 | rna-NM_001183161.1_CBS6413 | cds-NP_014076.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:25772-27016:+ | gene-YNL323W_CENPK1137D | rna-NM_001183161.1_CENPK1137D | cds-NP_014076.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:22772-24016:+ | gene-YNL323W_EthanolRed | rna-NM_001183161.1_EthanolRed | cds-NP_014076.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:23671-24915:+ | gene-YNL323W_FaliES1 | rna-NM_001183161.1_FaliES1 | cds-NP_014076.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000390.1:30611-31855:- | gene-YNL323W_JAY291 | rna-NM_001183161.1_JAY291 | cds-NP_014076.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:35344-36588:+ | gene-YNL323W_MUCL30387 | rna-NM_001183161.1_MUCL30387 | cds-NP_014076.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:28375-29619:+ | gene-YNL323W_MUCL30388 | rna-NM_001183161.1_MUCL30388 | cds-NP_014076.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:23714-24958:+ | gene-YNL323W_MUCL39482 | rna-NM_001183161.1_MUCL39482 | cds-NP_014076.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:25404-26648:+ | gene-YNL323W_MUCL42920 | rna-NM_001183161.1_MUCL42920 | cds-NP_014076.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:31913-33157:+ | gene-YNL323W_NCIM3186 | rna-NM_001183161.1_NCIM3186 | cds-NP_014076.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:25046-26290:+ | gene-YNL323W_NCYC1407 | rna-NM_001183161.1_NCYC1407 | cds-NP_014076.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:22243-23487:+ | gene-YNL323W_PE2H3 | rna-NM_001183161.1_PE2H3 | cds-NP_014076.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:21631-22875:+ | gene-YNL323W_PE2H4 | rna-NM_001183161.1_PE2H4 | cds-NP_014076.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:31944-33188:+ | gene-YNL323W_S288C | rna-NM_001183161.1_S288C | cds-NP_014076.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:64027-65271:- | gene-YNL323W_SA1 | rna-NM_001183161.1_SA1 | cds-NP_014076.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:24528-25772:+ | gene-YNL323W_ThermosaccDry | rna-NM_001183161.1_ThermosaccDry | cds-NP_014076.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:37061-38305:+ | gene-YNL323W_VR1 | rna-NM_001183161.1_VR1 | cds-NP_014076.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:15737-16981:+ | gene-YNL323W_ZTW1 | rna-NM_001183161.1_ZTW1 | cds-NP_014076.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:33690-34934:+ | gene-YNL323W_Sparadoxus | rna-NM_001183161.1_Sparadoxus | cds-NP_014076.1_Sparadoxus | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |