Gene name: LCB4
Reference locus (S288C): YOR171C
Gene biotype: protein_coding
Description: Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication
Top 10 interactors (score): DPL1 (0.997); LCB3 (0.997); YSR3 (0.994); SUR2 (0.989); LAC1 (0.987); LAG1 (0.987); YDC1 (0.982); YPC1 (0.98); LCB5 (0.957); TSC10 (0.94); PKC1 (0.909); LCB2 (0.908); LCB1 (0.889); YPL199C (0.888); ISC1 (0.866); AKR2 (0.793); AKR1 (0.791); ENV7 (0.79); SCS7 (0.778); SVF1 (0.753)
Homologues (species, bitscore): SPHK1 (Homo sapiens, 127.5); Sphk1 (Mus musculus, 127.5); SPHK1 (Danio rerio, 124.8); sphk1 (Xenopus tropicalis, 155.6); Sk2 (Drosophila melanogaster, 132.1); sphk-1 (Caenorhabditis elegans, 77.0); SPHK1 (Arabidopsis thaliana, 132.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:649647-651521:- | gene-YOR171C_AKU4011 | rna-NM_001183590.1_AKU4011 | cds-NP_014814.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:51403-53277:- | gene-YOR171C_BG1 | rna-NM_001183590.1_BG1 | cds-NP_014814.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:633722-635596:- | gene-YOR171C_Bruggeman | rna-NM_001183590.1_Bruggeman | cds-NP_014814.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:633740-635614:- | gene-YOR171C_CAT1 | rna-NM_001183590.1_CAT1 | cds-NP_014814.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:632142-634016:- | gene-YOR171C_CBS1585 | rna-NM_001183590.1_CBS1585 | cds-NP_014814.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:630438-632312:- | gene-YOR171C_CBS436 | rna-NM_001183590.1_CBS436 | cds-NP_014814.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:629754-631628:- | gene-YOR171C_CBS6412 | rna-NM_001183590.1_CBS6412 | cds-NP_014814.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:638435-640309:- | gene-YOR171C_CBS6413 | rna-NM_001183590.1_CBS6413 | cds-NP_014814.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:651769-653640:- | gene-YOR171C_CENPK1137D | rna-NM_001183590.1_CENPK1137D | cds-NP_014814.1_CENPK1137D | 98.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:625851-627725:- | gene-YOR171C_EthanolRed | rna-NM_001183590.1_EthanolRed | cds-NP_014814.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:630704-632578:- | gene-YOR171C_FaliES1 | rna-NM_001183590.1_FaliES1 | cds-NP_014814.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000070.1:10962-12836:+ | gene-YOR171C_JAY291 | rna-NM_001183590.1_JAY291 | cds-NP_014814.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:638529-640403:- | gene-YOR171C_MUCL30387 | rna-NM_001183590.1_MUCL30387 | cds-NP_014814.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:645291-647165:- | gene-YOR171C_MUCL30388 | rna-NM_001183590.1_MUCL30388 | cds-NP_014814.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:639983-641857:- | gene-YOR171C_MUCL39482 | rna-NM_001183590.1_MUCL39482 | cds-NP_014814.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:649406-651280:- | gene-YOR171C_MUCL42920 | rna-NM_001183590.1_MUCL42920 | cds-NP_014814.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:651899-653773:- | gene-YOR171C_NCIM3186 | rna-NM_001183590.1_NCIM3186 | cds-NP_014814.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:640069-641943:- | gene-YOR171C_NCYC1407 | rna-NM_001183590.1_NCYC1407 | cds-NP_014814.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:638583-640457:- | gene-YOR171C_PE2H3 | rna-NM_001183590.1_PE2H3 | cds-NP_014814.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:648960-650834:- | gene-YOR171C_PE2H4 | rna-NM_001183590.1_PE2H4 | cds-NP_014814.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:652010-653884:- | gene-YOR171C_S288C | rna-NM_001183590.1_S288C | cds-NP_014814.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:68568-70442:- | gene-YOR171C_SA1 | rna-NM_001183590.1_SA1 | cds-NP_014814.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:629887-631761:- | gene-YOR171C_ThermosaccDry | rna-NM_001183590.1_ThermosaccDry | cds-NP_014814.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:693585-695459:- | gene-YOR171C_VR1 | rna-NM_001183590.1_VR1 | cds-NP_014814.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:363337-365211:- | gene-YOR171C_ZTW1 | rna-NM_001183590.1_ZTW1 | cds-NP_014814.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:634954-636828:- | gene-YOR171C_Sparadoxus | rna-NM_001183590.1_Sparadoxus | cds-NP_014814.1_Sparadoxus | 88.7 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |