Gene name: LAS17
Reference locus (S288C): YOR181W
Gene biotype: protein_coding
Description: Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches
Top 10 interactors (score): ACT1 (0.999); VRP1 (0.999); CDC42 (0.999); ARC35 (0.999); BZZ1 (0.999); ARC19 (0.999); ARC18 (0.999); MYO5 (0.999); MYO3 (0.999); RVS167 (0.999); ARP3 (0.999); ARP2 (0.999); SLA1 (0.997); PAN1 (0.996); ARC40 (0.996); ARC15 (0.995); PFY1 (0.994); PIN3 (0.994); BBC1 (0.993); SLA2 (0.991)
Homologues (species, bitscore): WASL (Homo sapiens, 94.7); Wasl (Mus musculus, 96.3); wasa (Danio rerio, 106.3); wasl (Xenopus tropicalis, 87.0); WASp (Drosophila melanogaster, 67.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:673269-675170:+ | gene-YOR181W_AKU4011 | rna-NM_001183600.1_AKU4011 | cds-NP_014824.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:75328-77229:+ | gene-YOR181W_BG1 | rna-NM_001183600.1_BG1 | cds-NP_014824.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:657281-659182:+ | gene-YOR181W_Bruggeman | rna-NM_001183600.1_Bruggeman | cds-NP_014824.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:658454-660355:+ | gene-YOR181W_CAT1 | rna-NM_001183600.1_CAT1 | cds-NP_014824.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:656258-658159:+ | gene-YOR181W_CBS1585 | rna-NM_001183600.1_CBS1585 | cds-NP_014824.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:654379-656280:+ | gene-YOR181W_CBS436 | rna-NM_001183600.1_CBS436 | cds-NP_014824.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:653374-655275:+ | gene-YOR181W_CBS6412 | rna-NM_001183600.1_CBS6412 | cds-NP_014824.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:662015-663916:+ | gene-YOR181W_CBS6413 | rna-NM_001183600.1_CBS6413 | cds-NP_014824.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:675689-677590:+ | gene-YOR181W_CENPK1137D | rna-NM_001183600.1_CENPK1137D | cds-NP_014824.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:649245-651146:+ | gene-YOR181W_EthanolRed | rna-NM_001183600.1_EthanolRed | cds-NP_014824.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:654318-656219:+ | gene-YOR181W_FaliES1 | rna-NM_001183600.1_FaliES1 | cds-NP_014824.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000038.1:21319-23220:- | gene-YOR181W_JAY291 | rna-NM_001183600.1_JAY291 | cds-NP_014824.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:662086-663987:+ | gene-YOR181W_MUCL30387 | rna-NM_001183600.1_MUCL30387 | cds-NP_014824.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:669502-671403:+ | gene-YOR181W_MUCL30388 | rna-NM_001183600.1_MUCL30388 | cds-NP_014824.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:663587-665488:+ | gene-YOR181W_MUCL39482 | rna-NM_001183600.1_MUCL39482 | cds-NP_014824.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:672974-674875:+ | gene-YOR181W_MUCL42920 | rna-NM_001183600.1_MUCL42920 | cds-NP_014824.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:675828-677729:+ | gene-YOR181W_NCIM3186 | rna-NM_001183600.1_NCIM3186 | cds-NP_014824.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:663685-665586:+ | gene-YOR181W_NCYC1407 | rna-NM_001183600.1_NCYC1407 | cds-NP_014824.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:662511-664412:+ | gene-YOR181W_PE2H3 | rna-NM_001183600.1_PE2H3 | cds-NP_014824.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:672888-674789:+ | gene-YOR181W_PE2H4 | rna-NM_001183600.1_PE2H4 | cds-NP_014824.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:675939-677840:+ | gene-YOR181W_S288C | rna-NM_001183600.1_S288C | cds-NP_014824.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:92508-94409:+ | gene-YOR181W_SA1 | rna-NM_001183600.1_SA1 | cds-NP_014824.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:653502-655403:+ | gene-YOR181W_ThermosaccDry | rna-NM_001183600.1_ThermosaccDry | cds-NP_014824.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:717541-719442:+ | gene-YOR181W_VR1 | rna-NM_001183600.1_VR1 | cds-NP_014824.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:386910-388810:+ | gene-YOR181W_ZTW1 | rna-NM_001183600.1_ZTW1 | cds-NP_014824.1_ZTW1 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:659101-661047:+ | gene-YOR181W_Sparadoxus | rna-NM_001183600.1_Sparadoxus | cds-NP_014824.1_Sparadoxus | 85.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |