Gene name: LAS1
Reference locus (S288C): YKR063C
Gene biotype: protein_coding
Description: Protein LAS1; Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability
Top 10 interactors (score): GRC3 (0.999); IPI1 (0.995); IPI3 (0.994); RPF1 (0.969); EBP2 (0.941); NUG1 (0.927); NOP2 (0.921); ULP1 (0.912); NOP7 (0.896); YCR087C-A (0.886); RPA49 (0.883); ESF1 (0.877); SPB1 (0.868); MAK16 (0.862); RRS1 (0.862); DBP3 (0.856); NIP7 (0.853); RAT1 (0.852); SSF1 (0.85); NSA1 (0.845)
Homologues (species, bitscore): LAS1L (Homo sapiens, 74.3); Las1l (Mus musculus, 73.6); LOC561321 (Danio rerio, 88.2); las1l (Xenopus tropicalis, 67.8); CG32075 (Drosophila melanogaster, 71.2); AT5G12220 (Arabidopsis thaliana, 82.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:546830-548338:- | gene-YKR063C_AKU4011 | rna-NM_001179853.3_AKU4011 | cds-NP_012989.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:95935-97443:+ | gene-YKR063C_BG1 | rna-NM_001179853.3_BG1 | cds-NP_012989.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:568258-569766:- | gene-YKR063C_Bruggeman | rna-NM_001179853.3_Bruggeman | cds-NP_012989.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:564682-566190:- | gene-YKR063C_CAT1 | rna-NM_001179853.3_CAT1 | cds-NP_012989.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:559321-560829:- | gene-YKR063C_CBS1585 | rna-NM_001179853.3_CBS1585 | cds-NP_012989.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:557655-559163:- | gene-YKR063C_CBS436 | rna-NM_001179853.3_CBS436 | cds-NP_012989.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:542611-544119:- | gene-YKR063C_CBS6412 | rna-NM_001179853.3_CBS6412 | cds-NP_012989.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:559141-560649:- | gene-YKR063C_CBS6413 | rna-NM_001179853.3_CBS6413 | cds-NP_012989.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:560443-561951:- | gene-YKR063C_CENPK1137D | rna-NM_001179853.3_CENPK1137D | cds-NP_012989.3_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:556139-557647:- | gene-YKR063C_EthanolRed | rna-NM_001179853.3_EthanolRed | cds-NP_012989.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:560039-561547:- | gene-YKR063C_FaliES1 | rna-NM_001179853.3_FaliES1 | cds-NP_012989.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000410.1:16686-18194:+ | gene-YKR063C_JAY291 | rna-NM_001179853.3_JAY291 | cds-NP_012989.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:568657-570165:- | gene-YKR063C_MUCL30387 | rna-NM_001179853.3_MUCL30387 | cds-NP_012989.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:563269-564777:- | gene-YKR063C_MUCL30388 | rna-NM_001179853.3_MUCL30388 | cds-NP_012989.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:558150-559658:- | gene-YKR063C_MUCL39482 | rna-NM_001179853.3_MUCL39482 | cds-NP_012989.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:564172-565680:- | gene-YKR063C_MUCL42920 | rna-NM_001179853.3_MUCL42920 | cds-NP_012989.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:560778-562286:- | gene-YKR063C_NCIM3186 | rna-NM_001179853.3_NCIM3186 | cds-NP_012989.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:558573-560081:- | gene-YKR063C_NCYC1407 | rna-NM_001179853.3_NCYC1407 | cds-NP_012989.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:583732-585240:- | gene-YKR063C_PE2H3 | rna-NM_001179853.3_PE2H3 | cds-NP_012989.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:568127-569632:- | gene-YKR063C_PE2H4 | rna-NM_001179853.3_PE2H4 | cds-NP_012989.3_PE2H4 | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:560789-562297:- | gene-YKR063C_S288C | rna-NM_001179853.3_S288C | cds-NP_012989.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000029.1:119546-121054:+ | gene-YKR063C_SA1 | rna-NM_001179853.3_SA1 | cds-NP_012989.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:559278-560786:- | gene-YKR063C_ThermosaccDry | rna-NM_001179853.3_ThermosaccDry | cds-NP_012989.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:559048-560553:- | gene-YKR063C_VR1 | rna-NM_001179853.3_VR1 | cds-NP_012989.3_VR1 | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:556766-558274:- | gene-YKR063C_ZTW1 | rna-NM_001179853.3_ZTW1 | cds-NP_012989.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:582170-583675:- | gene-YKR063C_Sparadoxus | rna-NM_001179853.3_Sparadoxus | cds-NP_012989.3_Sparadoxus | 87.4 | 99.6 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |