Gene name: LAM6
Reference locus (S288C): YLR072W
Gene biotype: protein_coding
Description: Membrane-anchored lipid-binding protein LAM6; Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes; Belongs to the YSP2 family
Top 10 interactors (score): TOM71 (0.961); TOM70 (0.943); VAC8 (0.921); MDM34 (0.814); GEM1 (0.813); NPC2 (0.813); LAM1 (0.768); MDM12 (0.76); MDM10 (0.754); SIP3 (0.751); VPS13 (0.745); NVJ1 (0.712); MFB1 (0.71); YPR063C (0.7); IVY1 (0.691); PRY1 (0.651); VAM6 (0.62); VPH1 (0.607); PRY2 (0.569); MNL2 (0.568)
Homologues (species, bitscore): GRAMD1A (Homo sapiens, 84.7); Gramd1a (Mus musculus, 86.3); GRAMD1C (Danio rerio, 82.0); GRAMD1A (Xenopus tropicalis, 84.0); CG34394 (Drosophila melanogaster, 77.8); ZC328.3 (Caenorhabditis elegans, 83.6); VAD1 (Arabidopsis thaliana, 62.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:261336-263417:+ | gene-YLR072W_AKU4011 | rna-NM_001181959.1_AKU4011 | cds-NP_013173.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:224471-226549:+ | gene-YLR072W_BG1 | rna-NM_001181959.1_BG1 | cds-NP_013173.1_BG1 | 99.1 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:271243-273324:+ | gene-YLR072W_Bruggeman | rna-NM_001181959.1_Bruggeman | cds-NP_013173.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:271556-273637:+ | gene-YLR072W_CAT1 | rna-NM_001181959.1_CAT1 | cds-NP_013173.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:268450-270531:+ | gene-YLR072W_CBS1585 | rna-NM_001181959.1_CBS1585 | cds-NP_013173.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:259068-261149:+ | gene-YLR072W_CBS436 | rna-NM_001181959.1_CBS436 | cds-NP_013173.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:266888-268969:+ | gene-YLR072W_CBS6412 | rna-NM_001181959.1_CBS6412 | cds-NP_013173.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:268721-270802:+ | gene-YLR072W_CBS6413 | rna-NM_001181959.1_CBS6413 | cds-NP_013173.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:263884-265965:+ | gene-YLR072W_CENPK1137D | rna-NM_001181959.1_CENPK1137D | cds-NP_013173.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:260855-262936:+ | gene-YLR072W_EthanolRed | rna-NM_001181959.1_EthanolRed | cds-NP_013173.1_EthanolRed | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:260731-262812:+ | gene-YLR072W_FaliES1 | rna-NM_001181959.1_FaliES1 | cds-NP_013173.1_FaliES1 | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:35662-37743:+ | gene-YLR072W_JAY291 | rna-NM_001181959.1_JAY291 | cds-NP_013173.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:268609-270690:+ | gene-YLR072W_MUCL30387 | rna-NM_001181959.1_MUCL30387 | cds-NP_013173.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:276255-278336:+ | gene-YLR072W_MUCL30388 | rna-NM_001181959.1_MUCL30388 | cds-NP_013173.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:268963-271053:+ | gene-YLR072W_MUCL39482 | rna-NM_001181959.1_MUCL39482 | cds-NP_013173.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:268882-270963:+ | gene-YLR072W_MUCL42920 | rna-NM_001181959.1_MUCL42920 | cds-NP_013173.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:278836-280917:+ | gene-YLR072W_NCIM3186 | rna-NM_001181959.1_NCIM3186 | cds-NP_013173.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:261036-263117:+ | gene-YLR072W_NCYC1407 | rna-NM_001181959.1_NCYC1407 | cds-NP_013173.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:266899-268980:+ | gene-YLR072W_PE2H3 | rna-NM_001181959.1_PE2H3 | cds-NP_013173.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:266640-268721:+ | gene-YLR072W_PE2H4 | rna-NM_001181959.1_PE2H4 | cds-NP_013173.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:278862-280943:+ | gene-YLR072W_S288C | rna-NM_001181959.1_S288C | cds-NP_013173.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000033.1:93251-95329:- | gene-YLR072W_SA1 | rna-NM_001181959.1_SA1 | cds-NP_013173.1_SA1 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:260907-262988:+ | gene-YLR072W_ThermosaccDry | rna-NM_001181959.1_ThermosaccDry | cds-NP_013173.1_ThermosaccDry | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:274592-276673:+ | gene-YLR072W_VR1 | rna-NM_001181959.1_VR1 | cds-NP_013173.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:260294-262375:+ | gene-YLR072W_ZTW1 | rna-NM_001181959.1_ZTW1 | cds-NP_013173.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:269178-271268:+ | gene-YLR072W_Sparadoxus | rna-NM_001181959.1_Sparadoxus | cds-NP_013173.1_Sparadoxus | 89.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |