Gene name: LAM4
Reference locus (S288C): YHR080C
Gene biotype: protein_coding
Description: Membrane-anchored lipid-binding protein LAM4; Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Top 10 interactors (score): SIP3 (0.92); LAM1 (0.895); PRY1 (0.679); MRPS12 (0.656); DGR2 (0.619); YNL144C (0.61); AIM41 (0.588); LNP1 (0.575); KES1 (0.573); PET117 (0.571); ICY1 (0.567); YKL162C (0.56); NNR1 (0.553); TCB2 (0.552); UPC2 (0.535); QRI7 (0.529); YJL193W (0.528); THI73 (0.527); EIS1 (0.512); YSP2 (0.501)
Homologues (species, bitscore): GRAMD1B (Homo sapiens, 114.4); Gramd1b (Mus musculus, 111.3); gramd1ba (Danio rerio, 121.3); GRAMD1A (Xenopus tropicalis, 107.5); CG34394 (Drosophila melanogaster, 118.6); ZC328.3 (Caenorhabditis elegans, 104.0); VAD1 (Arabidopsis thaliana, 93.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:249212-253249:- | gene-YHR080C_AKU4011 | rna-NM_001179210.1_AKU4011 | cds-NP_011948.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:169559-173596:- | gene-YHR080C_BG1 | rna-NM_001179210.1_BG1 | cds-NP_011948.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:257039-261076:- | gene-YHR080C_Bruggeman | rna-NM_001179210.1_Bruggeman | cds-NP_011948.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:252182-256219:- | gene-YHR080C_CAT1 | rna-NM_001179210.1_CAT1 | cds-NP_011948.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:248254-252291:- | gene-YHR080C_CBS1585 | rna-NM_001179210.1_CBS1585 | cds-NP_011948.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:246115-250152:- | gene-YHR080C_CBS436 | rna-NM_001179210.1_CBS436 | cds-NP_011948.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:251601-255638:- | gene-YHR080C_CBS6412 | rna-NM_001179210.1_CBS6412 | cds-NP_011948.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:249293-253330:- | gene-YHR080C_CBS6413 | rna-NM_001179210.1_CBS6413 | cds-NP_011948.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:255972-260009:- | gene-YHR080C_CENPK1137D | rna-NM_001179210.1_CENPK1137D | cds-NP_011948.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:308819-312856:- | gene-YHR080C_EthanolRed | rna-NM_001179210.1_EthanolRed | cds-NP_011948.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:249623-253660:- | gene-YHR080C_FaliES1 | rna-NM_001179210.1_FaliES1 | cds-NP_011948.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000394.1:32348-36385:- | gene-YHR080C_JAY291 | rna-NM_001179210.1_JAY291 | cds-NP_011948.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:256559-260596:- | gene-YHR080C_MUCL30387 | rna-NM_001179210.1_MUCL30387 | cds-NP_011948.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:256423-260460:- | gene-YHR080C_MUCL30388 | rna-NM_001179210.1_MUCL30388 | cds-NP_011948.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:248577-252614:- | gene-YHR080C_MUCL39482 | rna-NM_001179210.1_MUCL39482 | cds-NP_011948.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:255322-259359:- | gene-YHR080C_MUCL42920 | rna-NM_001179210.1_MUCL42920 | cds-NP_011948.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:262683-266720:- | gene-YHR080C_NCIM3186 | rna-NM_001179210.1_NCIM3186 | cds-NP_011948.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:251041-255078:- | gene-YHR080C_NCYC1407 | rna-NM_001179210.1_NCYC1407 | cds-NP_011948.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:250712-254749:- | gene-YHR080C_PE2H3 | rna-NM_001179210.1_PE2H3 | cds-NP_011948.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:258159-262196:- | gene-YHR080C_PE2H4 | rna-NM_001179210.1_PE2H4 | cds-NP_011948.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:262801-266838:- | gene-YHR080C_S288C | rna-NM_001179210.1_S288C | cds-NP_011948.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:92150-96187:+ | gene-YHR080C_SA1 | rna-NM_001179210.1_SA1 | cds-NP_011948.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:250714-254751:- | gene-YHR080C_ThermosaccDry | rna-NM_001179210.1_ThermosaccDry | cds-NP_011948.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:258587-262624:- | gene-YHR080C_VR1 | rna-NM_001179210.1_VR1 | cds-NP_011948.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:242266-246303:- | gene-YHR080C_ZTW1 | rna-NM_001179210.1_ZTW1 | cds-NP_011948.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:247968-252068:- | gene-YHR080C_Sparadoxus | rna-NM_001179210.1_Sparadoxus | cds-NP_011948.1_Sparadoxus | 85.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |