Gene name: LAG1
Reference locus (S288C): YHL003C
Gene biotype: protein_coding
Description: Sphingosine N-acyltransferase LAG1; Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication
Top 10 interactors (score): LIP1 (0.997); LAC1 (0.994); YDC1 (0.99); YPC1 (0.988); LCB3 (0.987); LCB4 (0.987); LCB5 (0.985); TSC10 (0.985); SCS7 (0.985); SUR2 (0.983); YSR3 (0.976); LCB2 (0.921); LCB1 (0.916); ISC1 (0.907); TDA10 (0.832); ORM2 (0.83); DPL1 (0.823); ORM1 (0.805); ELO3 (0.787); AUR1 (0.773)
Homologues (species, bitscore): CERS2 (Homo sapiens, 72.8); Cers4 (Mus musculus, 80.5); cers4b (Danio rerio, 81.3); cers2 (Xenopus tropicalis, 69.3); schlank (Drosophila melanogaster, 55.8); hyl-1 (Caenorhabditis elegans, 97.8); LAG13 (Arabidopsis thaliana, 74.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:89261-90496:- | gene-YHL003C_AKU4011 | rna-NM_001179083.1_AKU4011 | cds-NP_011860.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:8976-10211:- | gene-YHL003C_BG1 | rna-NM_001179083.1_BG1 | cds-NP_011860.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:96118-97353:- | gene-YHL003C_Bruggeman | rna-NM_001179083.1_Bruggeman | cds-NP_011860.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:90102-91337:- | gene-YHL003C_CAT1 | rna-NM_001179083.1_CAT1 | cds-NP_011860.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:89848-91083:- | gene-YHL003C_CBS1585 | rna-NM_001179083.1_CBS1585 | cds-NP_011860.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:82346-83581:- | gene-YHL003C_CBS436 | rna-NM_001179083.1_CBS436 | cds-NP_011860.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:89447-90682:- | gene-YHL003C_CBS6412 | rna-NM_001179083.1_CBS6412 | cds-NP_011860.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:89173-90408:- | gene-YHL003C_CBS6413 | rna-NM_001179083.1_CBS6413 | cds-NP_011860.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:93805-95040:- | gene-YHL003C_CENPK1137D | rna-NM_001179083.1_CENPK1137D | cds-NP_011860.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:89257-90492:- | gene-YHL003C_EthanolRed | rna-NM_001179083.1_EthanolRed | cds-NP_011860.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:89786-91021:- | gene-YHL003C_FaliES1 | rna-NM_001179083.1_FaliES1 | cds-NP_011860.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000422.1:2951-4186:+ | gene-YHL003C_JAY291 | rna-NM_001179083.1_JAY291 | cds-NP_011860.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:92858-94093:- | gene-YHL003C_MUCL30387 | rna-NM_001179083.1_MUCL30387 | cds-NP_011860.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:94069-95304:- | gene-YHL003C_MUCL30388 | rna-NM_001179083.1_MUCL30388 | cds-NP_011860.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:88874-90109:- | gene-YHL003C_MUCL39482 | rna-NM_001179083.1_MUCL39482 | cds-NP_011860.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:92781-94016:- | gene-YHL003C_MUCL42920 | rna-NM_001179083.1_MUCL42920 | cds-NP_011860.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:100530-101765:- | gene-YHL003C_NCIM3186 | rna-NM_001179083.1_NCIM3186 | cds-NP_011860.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:88290-89525:- | gene-YHL003C_NCYC1407 | rna-NM_001179083.1_NCYC1407 | cds-NP_011860.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:90495-91730:- | gene-YHL003C_PE2H3 | rna-NM_001179083.1_PE2H3 | cds-NP_011860.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:97936-99171:- | gene-YHL003C_PE2H4 | rna-NM_001179083.1_PE2H4 | cds-NP_011860.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:100648-101883:- | gene-YHL003C_S288C | rna-NM_001179083.1_S288C | cds-NP_011860.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000075.1:44660-45895:+ | gene-YHL003C_SA1 | rna-NM_001179083.1_SA1 | cds-NP_011860.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:90876-92111:- | gene-YHL003C_ThermosaccDry | rna-NM_001179083.1_ThermosaccDry | cds-NP_011860.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:96422-97657:- | gene-YHL003C_VR1 | rna-NM_001179083.1_VR1 | cds-NP_011860.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:82041-83276:- | gene-YHL003C_ZTW1 | rna-NM_001179083.1_ZTW1 | cds-NP_011860.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:88544-89779:- | gene-YHL003C_Sparadoxus | rna-NM_001179083.1_Sparadoxus | cds-NP_011860.1_Sparadoxus | 92.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |