Gene name: LAF1
Reference locus (S288C): YMR102C
Gene biotype: protein_coding
Description: WD repeat-containing protein YMR102C; Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; not an essential gene; YMR102C has a paralog, DGR2, that arose from the whole genome duplication
Top 10 interactors (score): YEL034C-A (0.81); PGM1 (0.795); YMR099C (0.765); YBR013C (0.744); YMR103C (0.744); YLR407W (0.713); YOL166C (0.71); YLR419W (0.706); YLR345W (0.692); PMU1 (0.673); MED4 (0.645); YDR248C (0.637); YPK1 (0.635); PGM2 (0.629); RMA1 (0.619); CIS1 (0.599); ROT2 (0.593); YGR283C (0.574); LCL1 (0.57); POA1 (0.57)
Homologues (species, bitscore): WDR44 (Homo sapiens, 186.0); Wdr44 (Mus musculus, 185.7); WDR44 (Danio rerio, 188.7); wdr44 (Xenopus tropicalis, 183.0); CG34133 (Drosophila melanogaster, 180.6); sym-4 (Caenorhabditis elegans, 182.6); AT3G15470 (Arabidopsis thaliana, 186.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:507791-510295:- | gene-YMR102C_AKU4011 | rna-NM_001182602.1_AKU4011 | cds-NP_013820.1_AKU4011 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:32720-35224:+ | gene-YMR102C_BG1 | rna-NM_001182602.1_BG1 | cds-NP_013820.1_BG1 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:450218-452722:- | gene-YMR102C_Bruggeman | rna-NM_001182602.1_Bruggeman | cds-NP_013820.1_Bruggeman | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:450540-453044:- | gene-YMR102C_CAT1 | rna-NM_001182602.1_CAT1 | cds-NP_013820.1_CAT1 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:440738-443242:- | gene-YMR102C_CBS1585 | rna-NM_001182602.1_CBS1585 | cds-NP_013820.1_CBS1585 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:446053-448557:- | gene-YMR102C_CBS436 | rna-NM_001182602.1_CBS436 | cds-NP_013820.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:553832-556336:- | gene-YMR102C_CBS6412 | rna-NM_001182602.1_CBS6412 | cds-NP_013820.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:439995-442499:- | gene-YMR102C_CBS6413 | rna-NM_001182602.1_CBS6413 | cds-NP_013820.1_CBS6413 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:463955-466459:- | gene-YMR102C_CENPK1137D | rna-NM_001182602.1_CENPK1137D | cds-NP_013820.1_CENPK1137D | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:440630-443134:- | gene-YMR102C_EthanolRed | rna-NM_001182602.1_EthanolRed | cds-NP_013820.1_EthanolRed | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:443795-446299:- | gene-YMR102C_FaliES1 | rna-NM_001182602.1_FaliES1 | cds-NP_013820.1_FaliES1 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000349.1:6601-9105:- | gene-YMR102C_JAY291 | rna-NM_001182602.1_JAY291 | cds-NP_013820.1_JAY291 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:447141-449645:- | gene-YMR102C_MUCL30387 | rna-NM_001182602.1_MUCL30387 | cds-NP_013820.1_MUCL30387 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:451137-453641:- | gene-YMR102C_MUCL30388 | rna-NM_001182602.1_MUCL30388 | cds-NP_013820.1_MUCL30388 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:441044-443548:- | gene-YMR102C_MUCL39482 | rna-NM_001182602.1_MUCL39482 | cds-NP_013820.1_MUCL39482 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:447707-450211:- | gene-YMR102C_MUCL42920 | rna-NM_001182602.1_MUCL42920 | cds-NP_013820.1_MUCL42920 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:469802-472306:- | gene-YMR102C_NCIM3186 | rna-NM_001182602.1_NCIM3186 | cds-NP_013820.1_NCIM3186 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:440939-443443:- | gene-YMR102C_NCYC1407 | rna-NM_001182602.1_NCYC1407 | cds-NP_013820.1_NCYC1407 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:446651-449155:- | gene-YMR102C_PE2H3 | rna-NM_001182602.1_PE2H3 | cds-NP_013820.1_PE2H3 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:452746-455250:- | gene-YMR102C_PE2H4 | rna-NM_001182602.1_PE2H4 | cds-NP_013820.1_PE2H4 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:469848-472352:- | gene-YMR102C_S288C | rna-NM_001182602.1_S288C | cds-NP_013820.1_S288C | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000005.1:77814-80318:+ | gene-YMR102C_SA1 | rna-NM_001182602.1_SA1 | cds-NP_013820.1_SA1 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:441598-444102:- | gene-YMR102C_ThermosaccDry | rna-NM_001182602.1_ThermosaccDry | cds-NP_013820.1_ThermosaccDry | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:453237-455741:- | gene-YMR102C_VR1 | rna-NM_001182602.1_VR1 | cds-NP_013820.1_VR1 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:417867-420371:- | gene-YMR102C_ZTW1 | rna-NM_001182602.1_ZTW1 | cds-NP_013820.1_ZTW1 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:454128-456635:- | gene-YMR102C_Sparadoxus | rna-NM_001182602.1_Sparadoxus | cds-NP_013820.1_Sparadoxus | 90.2 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |