Gene name: LAC1
Reference locus (S288C): YKL008C
Gene biotype: protein_coding
Description: Sphingosine N-acyltransferase LAC1; Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication
Top 10 interactors (score): LIP1 (0.998); LAG1 (0.994); YDC1 (0.991); YPC1 (0.989); SUR2 (0.988); LCB3 (0.987); TSC10 (0.987); LCB4 (0.987); LCB5 (0.985); SCS7 (0.981); YSR3 (0.973); LCB2 (0.946); LCB1 (0.917); URA5 (0.91); ISC1 (0.901); ELO3 (0.874); DPL1 (0.866); ORM1 (0.861); PLB1 (0.844); AUR1 (0.81)
Homologues (species, bitscore): CERS5 (Homo sapiens, 68.2); Cers4 (Mus musculus, 72.4); cers4b (Danio rerio, 77.0); cers5 (Xenopus tropicalis, 68.6); schlank (Drosophila melanogaster, 57.8); hyl-1 (Caenorhabditis elegans, 85.1); LAG13 (Arabidopsis thaliana, 85.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:413312-414568:- | gene-YKL008C_AKU4011 | rna-NM_001179574.3_AKU4011 | cds-NP_012917.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:229335-230591:+ | gene-YKL008C_BG1 | rna-NM_001179574.3_BG1 | cds-NP_012917.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:435019-436275:- | gene-YKL008C_Bruggeman | rna-NM_001179574.3_Bruggeman | cds-NP_012917.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:430124-431380:- | gene-YKL008C_CAT1 | rna-NM_001179574.3_CAT1 | cds-NP_012917.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:426032-427288:- | gene-YKL008C_CBS1585 | rna-NM_001179574.3_CBS1585 | cds-NP_012917.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:424895-426151:- | gene-YKL008C_CBS436 | rna-NM_001179574.3_CBS436 | cds-NP_012917.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:410188-411444:- | gene-YKL008C_CBS6412 | rna-NM_001179574.3_CBS6412 | cds-NP_012917.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:425887-427143:- | gene-YKL008C_CBS6413 | rna-NM_001179574.3_CBS6413 | cds-NP_012917.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:426972-428228:- | gene-YKL008C_CENPK1137D | rna-NM_001179574.3_CENPK1137D | cds-NP_012917.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:423793-425049:- | gene-YKL008C_EthanolRed | rna-NM_001179574.3_EthanolRed | cds-NP_012917.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:425883-427139:- | gene-YKL008C_FaliES1 | rna-NM_001179574.3_FaliES1 | cds-NP_012917.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000142.1:3896-5152:+ | gene-YKL008C_JAY291 | rna-NM_001179574.3_JAY291 | cds-NP_012917.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:434334-435590:- | gene-YKL008C_MUCL30387 | rna-NM_001179574.3_MUCL30387 | cds-NP_012917.3_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:429943-431199:- | gene-YKL008C_MUCL30388 | rna-NM_001179574.3_MUCL30388 | cds-NP_012917.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:425349-426605:- | gene-YKL008C_MUCL39482 | rna-NM_001179574.3_MUCL39482 | cds-NP_012917.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:431179-432435:- | gene-YKL008C_MUCL42920 | rna-NM_001179574.3_MUCL42920 | cds-NP_012917.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:427284-428540:- | gene-YKL008C_NCIM3186 | rna-NM_001179574.3_NCIM3186 | cds-NP_012917.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:425541-426797:- | gene-YKL008C_NCYC1407 | rna-NM_001179574.3_NCYC1407 | cds-NP_012917.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:450232-451488:- | gene-YKL008C_PE2H3 | rna-NM_001179574.3_PE2H3 | cds-NP_012917.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:434974-436230:- | gene-YKL008C_PE2H4 | rna-NM_001179574.3_PE2H4 | cds-NP_012917.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:427295-428551:- | gene-YKL008C_S288C | rna-NM_001179574.3_S288C | cds-NP_012917.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:105576-106832:- | gene-YKL008C_SA1 | rna-NM_001179574.3_SA1 | cds-NP_012917.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:425982-427238:- | gene-YKL008C_ThermosaccDry | rna-NM_001179574.3_ThermosaccDry | cds-NP_012917.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:425254-426510:- | gene-YKL008C_VR1 | rna-NM_001179574.3_VR1 | cds-NP_012917.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:424026-425282:- | gene-YKL008C_ZTW1 | rna-NM_001179574.3_ZTW1 | cds-NP_012917.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:448998-450254:- | gene-YKL008C_Sparadoxus | rna-NM_001179574.3_Sparadoxus | cds-NP_012917.3_Sparadoxus | 94.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |