Gene name: KNS1
Reference locus (S288C): YLL019C
Gene biotype: protein_coding
Description: Dual specificity protein kinase KNS1; Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
Top 10 interactors (score): SKY1 (0.981); POL3 (0.852); YPL247C (0.77); RGA2 (0.756); RGA1 (0.756); CKB1 (0.722); CKA1 (0.714); SDP1 (0.713); MCK1 (0.683); HER2 (0.676); NGR1 (0.671); PTK2 (0.64); NAM8 (0.632); RPC53 (0.631); GDE1 (0.628); DUR1,2 (0.621); YLL020C (0.617); MSG5 (0.614); TUP1 (0.607); NPL3 (0.604)
Homologues (species, bitscore): CLK1 (Homo sapiens, 266.2); Clk1 (Mus musculus, 261.2); clk2b (Danio rerio, 245.7); clk2 (Xenopus tropicalis, 236.1); Doa (Drosophila melanogaster, 237.7); tag-172 (Caenorhabditis elegans, 249.2); AFC1 (Arabidopsis thaliana, 276.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:93438-95651:- | gene-YLL019C_AKU4011 | rna-NM_001181839.1_AKU4011 | cds-NP_013081.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:56927-59140:- | gene-YLL019C_BG1 | rna-NM_001181839.1_BG1 | cds-NP_013081.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:103262-105475:- | gene-YLL019C_Bruggeman | rna-NM_001181839.1_Bruggeman | cds-NP_013081.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:103878-106091:- | gene-YLL019C_CAT1 | rna-NM_001181839.1_CAT1 | cds-NP_013081.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:101035-103248:- | gene-YLL019C_CBS1585 | rna-NM_001181839.1_CBS1585 | cds-NP_013081.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:91403-93616:- | gene-YLL019C_CBS436 | rna-NM_001181839.1_CBS436 | cds-NP_013081.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:99798-102011:- | gene-YLL019C_CBS6412 | rna-NM_001181839.1_CBS6412 | cds-NP_013081.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:101295-103508:- | gene-YLL019C_CBS6413 | rna-NM_001181839.1_CBS6413 | cds-NP_013081.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:90710-92923:- | gene-YLL019C_CENPK1137D | rna-NM_001181839.1_CENPK1137D | cds-NP_013081.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:93478-95691:- | gene-YLL019C_EthanolRed | rna-NM_001181839.1_EthanolRed | cds-NP_013081.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:93049-95262:- | gene-YLL019C_FaliES1 | rna-NM_001181839.1_FaliES1 | cds-NP_013081.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000083.1:60101-62314:+ | gene-YLL019C_JAY291 | rna-NM_001181839.1_JAY291 | cds-NP_013081.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:101154-103367:- | gene-YLL019C_MUCL30387 | rna-NM_001181839.1_MUCL30387 | cds-NP_013081.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:105383-107596:- | gene-YLL019C_MUCL30388 | rna-NM_001181839.1_MUCL30388 | cds-NP_013081.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:101505-103718:- | gene-YLL019C_MUCL39482 | rna-NM_001181839.1_MUCL39482 | cds-NP_013081.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:101174-103387:- | gene-YLL019C_MUCL42920 | rna-NM_001181839.1_MUCL42920 | cds-NP_013081.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:105660-107873:- | gene-YLL019C_NCIM3186 | rna-NM_001181839.1_NCIM3186 | cds-NP_013081.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:93111-95324:- | gene-YLL019C_NCYC1407 | rna-NM_001181839.1_NCYC1407 | cds-NP_013081.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:99468-101681:- | gene-YLL019C_PE2H3 | rna-NM_001181839.1_PE2H3 | cds-NP_013081.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:99201-101414:- | gene-YLL019C_PE2H4 | rna-NM_001181839.1_PE2H4 | cds-NP_013081.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:105686-107899:- | gene-YLL019C_S288C | rna-NM_001181839.1_S288C | cds-NP_013081.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000062.1:8611-10824:- | gene-YLL019C_SA1 | rna-NM_001181839.1_SA1 | cds-NP_013081.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:93555-95768:- | gene-YLL019C_ThermosaccDry | rna-NM_001181839.1_ThermosaccDry | cds-NP_013081.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:107204-109417:- | gene-YLL019C_VR1 | rna-NM_001181839.1_VR1 | cds-NP_013081.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:92875-95088:- | gene-YLL019C_ZTW1 | rna-NM_001181839.1_ZTW1 | cds-NP_013081.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:101093-103306:- | gene-YLL019C_Sparadoxus | rna-NM_001181839.1_Sparadoxus | cds-NP_013081.1_Sparadoxus | 91.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |