Gene name: KCC4
Reference locus (S288C): YCL024W
Gene biotype: protein_coding
Description: Probable serine/threonine-protein kinase KCC4; Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily
Top 10 interactors (score): CDC3 (0.966); CDC11 (0.965); NAP1 (0.961); CDC10 (0.96); CDC12 (0.948); SWE1 (0.916); GIN4 (0.84); SHS1 (0.839); HSL1 (0.795); SAW1 (0.757); BNI4 (0.73); ELM1 (0.725); SMC1 (0.614); RTS1 (0.573); HAP2 (0.573); HYM1 (0.562); TEM1 (0.544); YER134C (0.527); SDS23 (0.518); SDS24 (0.518)
Homologues (species, bitscore): BRSK1 (Homo sapiens, 279.6); Brsk1 (Mus musculus, 280.4); si:dkey-16p21.7 (Danio rerio, 280.8); brsk1 (Xenopus tropicalis, 258.5); sff (Drosophila melanogaster, 276.9); sad-1 (Caenorhabditis elegans, 286.6); KIN10 (Arabidopsis thaliana, 273.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:80523-83636:+ | gene-YCL024W_AKU4011 | rna-NM_001178670.1_AKU4011 | cds-NP_009907.2_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000178.1:63472-66585:- | gene-YCL024W_BG1 | rna-NM_001178670.1_BG1 | cds-NP_009907.2_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:68712-71825:+ | gene-YCL024W_Bruggeman | rna-NM_001178670.1_Bruggeman | cds-NP_009907.2_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:80325-83438:+ | gene-YCL024W_CAT1 | rna-NM_001178670.1_CAT1 | cds-NP_009907.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:81172-84285:+ | gene-YCL024W_CBS1585 | rna-NM_001178670.1_CBS1585 | cds-NP_009907.2_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:79656-82769:+ | gene-YCL024W_CBS436 | rna-NM_001178670.1_CBS436 | cds-NP_009907.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:68621-71734:+ | gene-YCL024W_CBS6412 | rna-NM_001178670.1_CBS6412 | cds-NP_009907.2_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:79988-83101:+ | gene-YCL024W_CBS6413 | rna-NM_001178670.1_CBS6413 | cds-NP_009907.2_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:78759-81872:+ | gene-YCL024W_CENPK1137D | rna-NM_001178670.1_CENPK1137D | cds-NP_009907.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:78541-81654:+ | gene-YCL024W_EthanolRed | rna-NM_001178670.1_EthanolRed | cds-NP_009907.2_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:79501-82614:+ | gene-YCL024W_FaliES1 | rna-NM_001178670.1_FaliES1 | cds-NP_009907.2_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000225.1:1811-4924:- | gene-YCL024W_JAY291 | rna-NM_001178670.1_JAY291 | cds-NP_009907.2_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:66893-69956:+ | gene-YCL024W_MUCL30387 | rna-NM_001178670.1_MUCL30387 | cds-NP_009907.2_MUCL30387 | 97.0 | 98.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:67177-70290:+ | gene-YCL024W_MUCL30388 | rna-NM_001178670.1_MUCL30388 | cds-NP_009907.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:81588-84701:+ | gene-YCL024W_MUCL39482 | rna-NM_001178670.1_MUCL39482 | cds-NP_009907.2_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:67700-70813:+ | gene-YCL024W_MUCL42920 | rna-NM_001178670.1_MUCL42920 | cds-NP_009907.2_MUCL42920 | 99.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:78794-81907:+ | gene-YCL024W_NCIM3186 | rna-NM_001178670.1_NCIM3186 | cds-NP_009907.2_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:82071-85184:+ | gene-YCL024W_NCYC1407 | rna-NM_001178670.1_NCYC1407 | cds-NP_009907.2_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:79587-82700:+ | gene-YCL024W_PE2H3 | rna-NM_001178670.1_PE2H3 | cds-NP_009907.2_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:79544-82657:+ | gene-YCL024W_PE2H4 | rna-NM_001178670.1_PE2H4 | cds-NP_009907.2_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:79162-82275:+ | gene-YCL024W_S288C | rna-NM_001178670.1_S288C | cds-NP_009907.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000061.1:66292-69405:+ | gene-YCL024W_SA1 | rna-NM_001178670.1_SA1 | cds-NP_009907.2_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:79802-82915:+ | gene-YCL024W_ThermosaccDry | rna-NM_001178670.1_ThermosaccDry | cds-NP_009907.2_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:86075-89188:+ | gene-YCL024W_VR1 | rna-NM_001178670.1_VR1 | cds-NP_009907.2_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:79996-83109:+ | gene-YCL024W_ZTW1 | rna-NM_001178670.1_ZTW1 | cds-NP_009907.2_ZTW1 | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:109531-112650:+ | gene-YCL024W_Sparadoxus | rna-NM_001178670.1_Sparadoxus | cds-NP_009907.2_Sparadoxus | 85.4 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |