Gene name: JHD2
Reference locus (S288C): YJR119C
Gene biotype: protein_coding
Description: JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; regulates rDNA silencing
Top 10 interactors (score): BRE2 (0.997); SET1 (0.993); SWD1 (0.99); EAF3 (0.99); HHT2 (0.987); HHT1 (0.986); SIN3 (0.984); JHD1 (0.984); RCO1 (0.977); SET2 (0.965); RPD3 (0.94); MOT2 (0.92); ATP3 (0.915); ATP1 (0.912); ATP5 (0.907); ATP16 (0.907); ATP6 (0.896); RTT107 (0.881); HOS2 (0.865); SWD3 (0.857)
Homologues (species, bitscore): KDM5A (Homo sapiens, 292.0); Kdm5a (Mus musculus, 292.0); kdm5bb (Danio rerio, 287.3); kdm5b (Xenopus tropicalis, 296.6); lid (Drosophila melanogaster, 294.7); rbr-2 (Caenorhabditis elegans, 277.7); JMJ14 (Arabidopsis thaliana, 198.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:615796-617982:- | gene-YJR119C_AKU4011 | rna-NM_001181777.1_AKU4011 | cds-NP_012653.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:55592-57778:+ | gene-YJR119C_BG1 | rna-NM_001181777.1_BG1 | cds-NP_012653.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:631508-633694:- | gene-YJR119C_Bruggeman | rna-NM_001181777.1_Bruggeman | cds-NP_012653.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:635280-637466:- | gene-YJR119C_CAT1 | rna-NM_001181777.1_CAT1 | cds-NP_012653.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:627838-630024:- | gene-YJR119C_CBS1585 | rna-NM_001181777.1_CBS1585 | cds-NP_012653.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:646715-648901:- | gene-YJR119C_CBS436 | rna-NM_001181777.1_CBS436 | cds-NP_012653.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:614614-616800:- | gene-YJR119C_CBS6412 | rna-NM_001181777.1_CBS6412 | cds-NP_012653.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:617269-619455:- | gene-YJR119C_CBS6413 | rna-NM_001181777.1_CBS6413 | cds-NP_012653.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:626662-628848:- | gene-YJR119C_CENPK1137D | rna-NM_001181777.1_CENPK1137D | cds-NP_012653.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:620211-622397:- | gene-YJR119C_EthanolRed | rna-NM_001181777.1_EthanolRed | cds-NP_012653.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:631674-633860:- | gene-YJR119C_FaliES1 | rna-NM_001181777.1_FaliES1 | cds-NP_012653.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:55263-57448:+ | gene-YJR119C_JAY291 | rna-NM_001181777.1_JAY291 | cds-NP_012653.1_JAY291 | 99.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:630301-632487:- | gene-YJR119C_MUCL30387 | rna-NM_001181777.1_MUCL30387 | cds-NP_012653.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:628026-630212:- | gene-YJR119C_MUCL30388 | rna-NM_001181777.1_MUCL30388 | cds-NP_012653.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:621321-623507:- | gene-YJR119C_MUCL39482 | rna-NM_001181777.1_MUCL39482 | cds-NP_012653.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:625810-627996:- | gene-YJR119C_MUCL42920 | rna-NM_001181777.1_MUCL42920 | cds-NP_012653.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:644283-646469:- | gene-YJR119C_NCIM3186 | rna-NM_001181777.1_NCIM3186 | cds-NP_012653.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:618871-621057:- | gene-YJR119C_NCYC1407 | rna-NM_001181777.1_NCYC1407 | cds-NP_012653.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:637070-639256:- | gene-YJR119C_PE2H3 | rna-NM_001181777.1_PE2H3 | cds-NP_012653.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:630759-632945:- | gene-YJR119C_PE2H4 | rna-NM_001181777.1_PE2H4 | cds-NP_012653.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:644304-646490:- | gene-YJR119C_S288C | rna-NM_001181777.1_S288C | cds-NP_012653.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:55637-57823:+ | gene-YJR119C_SA1 | rna-NM_001181777.1_SA1 | cds-NP_012653.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:625605-627791:- | gene-YJR119C_ThermosaccDry | rna-NM_001181777.1_ThermosaccDry | cds-NP_012653.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:627993-630179:- | gene-YJR119C_VR1 | rna-NM_001181777.1_VR1 | cds-NP_012653.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:604957-607143:- | gene-YJR119C_ZTW1 | rna-NM_001181777.1_ZTW1 | cds-NP_012653.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:639199-641388:- | gene-YJR119C_Sparadoxus | rna-NM_001181777.1_Sparadoxus | cds-NP_012653.1_Sparadoxus | 88.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |