Gene name: IXR1
Reference locus (S288C): YKL032C
Gene biotype: protein_coding
Description: Intrastrand cross-link recognition protein; Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication
Top 10 interactors (score): NHP10 (0.845); HMO1 (0.84); ROX1 (0.826); DUN1 (0.824); NHP6A (0.798); SSN8 (0.773); YKL031W (0.765); MOT3 (0.758); SMT3 (0.736); NHP6B (0.718); SML1 (0.717); COX5B (0.702); RAD53 (0.673); SPT16 (0.671); HEM13 (0.659); RNR2 (0.653); YDR246W-A (0.65); STH1 (0.648); GCN4 (0.648); RNR1 (0.647)
Homologues (species, bitscore): TOX3 (Homo sapiens, 66.2); Tox3 (Mus musculus, 67.0); tox3 (Danio rerio, 63.9); hmgb3 (Xenopus tropicalis, 58.5); Dsp1 (Drosophila melanogaster, 101.7); hmg-1.2 (Caenorhabditis elegans, 53.9); 3xHMG-box2 (Arabidopsis thaliana, 65.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:366077-367873:- | gene-YKL032C_AKU4011 | rna-NM_001179598.3_AKU4011 | cds-NP_012893.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:276158-277909:+ | gene-YKL032C_BG1 | rna-NM_001179598.3_BG1 | cds-NP_012893.3_BG1 | 96.1 | 97.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:387070-389596:- | gene-YKL032C_Bruggeman | rna-NM_001179598.3_Bruggeman | cds-NP_012893.3_Bruggeman | 69.5 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:382020-384014:- | gene-YKL032C_CAT1 | rna-NM_001179598.3_CAT1 | cds-NP_012893.3_CAT1 | 84.8 | 97.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:378804-380600:- | gene-YKL032C_CBS1585 | rna-NM_001179598.3_CBS1585 | cds-NP_012893.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:377512-379290:- | gene-YKL032C_CBS436 | rna-NM_001179598.3_CBS436 | cds-NP_012893.3_CBS436 | 98.6 | 99.1 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:362941-364737:- | gene-YKL032C_CBS6412 | rna-NM_001179598.3_CBS6412 | cds-NP_012893.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:378770-380452:- | gene-YKL032C_CBS6413 | rna-NM_001179598.3_CBS6413 | cds-NP_012893.3_CBS6413 | 93.2 | 93.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:379723-381516:- | gene-YKL032C_CENPK1137D | rna-NM_001179598.3_CENPK1137D | cds-NP_012893.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:376564-378360:- | gene-YKL032C_EthanolRed | rna-NM_001179598.3_EthanolRed | cds-NP_012893.3_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:378666-380465:- | gene-YKL032C_FaliES1 | rna-NM_001179598.3_FaliES1 | cds-NP_012893.3_FaliES1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000080.1:82491-84242:- | gene-YKL032C_JAY291 | rna-NM_001179598.3_JAY291 | cds-NP_012893.3_JAY291 | 96.1 | 97.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:386845-388635:- | gene-YKL032C_MUCL30387 | rna-NM_001179598.3_MUCL30387 | cds-NP_012893.3_MUCL30387 | 96.7 | 98.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:382478-384250:- | gene-YKL032C_MUCL30388 | rna-NM_001179598.3_MUCL30388 | cds-NP_012893.3_MUCL30388 | 97.8 | 98.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:378100-379896:- | gene-YKL032C_MUCL39482 | rna-NM_001179598.3_MUCL39482 | cds-NP_012893.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:383547-385337:- | gene-YKL032C_MUCL42920 | rna-NM_001179598.3_MUCL42920 | cds-NP_012893.3_MUCL42920 | 96.7 | 98.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:380054-381847:- | gene-YKL032C_NCIM3186 | rna-NM_001179598.3_NCIM3186 | cds-NP_012893.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:378299-380095:- | gene-YKL032C_NCYC1407 | rna-NM_001179598.3_NCYC1407 | cds-NP_012893.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:402837-404588:- | gene-YKL032C_PE2H3 | rna-NM_001179598.3_PE2H3 | cds-NP_012893.3_PE2H3 | 96.1 | 97.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:387572-389323:- | gene-YKL032C_PE2H4 | rna-NM_001179598.3_PE2H4 | cds-NP_012893.3_PE2H4 | 96.1 | 97.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:380065-381858:- | gene-YKL032C_S288C | rna-NM_001179598.3_S288C | cds-NP_012893.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:58178-59926:- | gene-YKL032C_SA1 | rna-NM_001179598.3_SA1 | cds-NP_012893.3_SA1 | 96.0 | 96.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:378764-380563:- | gene-YKL032C_ThermosaccDry | rna-NM_001179598.3_ThermosaccDry | cds-NP_012893.3_ThermosaccDry | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:377905-379653:- | gene-YKL032C_VR1 | rna-NM_001179598.3_VR1 | cds-NP_012893.3_VR1 | 96.2 | 97.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:376788-378587:- | gene-YKL032C_ZTW1 | rna-NM_001179598.3_ZTW1 | cds-NP_012893.3_ZTW1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:395656-397416:- | gene-YKL032C_Sparadoxus | rna-NM_001179598.3_Sparadoxus | cds-NP_012893.3_Sparadoxus | 85.8 | 96.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |