Gene name: ISY1
Reference locus (S288C): YJR050W
Gene biotype: protein_coding
Description: Pre-mRNA-splicing factor ISY1; Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
Top 10 interactors (score): NTC20 (0.999); PRP45 (0.999); CDC40 (0.999); SYF1 (0.999); CEF1 (0.999); YJU2 (0.999); BUD31 (0.999); LEA1 (0.999); SYF2 (0.999); PRP19 (0.999); PRP46 (0.999); SNU114 (0.999); CWC2 (0.999); PRP16 (0.999); SNT309 (0.999); PRP8 (0.999); CLF1 (0.999); BRR2 (0.998); ECM2 (0.997); CWC21 (0.996)
Homologues (species, bitscore): ISY1-RAB43 (Homo sapiens, 73.2); Isy1 (Mus musculus, 72.4); rab43 (Danio rerio, 73.2); isy1 (Xenopus tropicalis, 60.5); CG9667 (Drosophila melanogaster, 58.5); F53B7.3 (Caenorhabditis elegans, 64.7); AT3G18790 (Arabidopsis thaliana, 69.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:500384-501091:+ | gene-YJR050W_AKU4011 | rna-NM_001181708.3_AKU4011 | cds-NP_012584.3_AKU4011 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:111898-112605:- | gene-YJR050W_BG1 | rna-NM_001181708.3_BG1 | cds-NP_012584.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:514433-515140:+ | gene-YJR050W_Bruggeman | rna-NM_001181708.3_Bruggeman | cds-NP_012584.3_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:518604-519311:+ | gene-YJR050W_CAT1 | rna-NM_001181708.3_CAT1 | cds-NP_012584.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:512454-513161:+ | gene-YJR050W_CBS1585 | rna-NM_001181708.3_CBS1585 | cds-NP_012584.3_CBS1585 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:530915-531622:+ | gene-YJR050W_CBS436 | rna-NM_001181708.3_CBS436 | cds-NP_012584.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:500169-500876:+ | gene-YJR050W_CBS6412 | rna-NM_001181708.3_CBS6412 | cds-NP_012584.3_CBS6412 | 98.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:502414-503121:+ | gene-YJR050W_CBS6413 | rna-NM_001181708.3_CBS6413 | cds-NP_012584.3_CBS6413 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:511060-511767:+ | gene-YJR050W_CENPK1137D | rna-NM_001181708.3_CENPK1137D | cds-NP_012584.3_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:505296-506003:+ | gene-YJR050W_EthanolRed | rna-NM_001181708.3_EthanolRed | cds-NP_012584.3_EthanolRed | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:516513-517220:+ | gene-YJR050W_FaliES1 | rna-NM_001181708.3_FaliES1 | cds-NP_012584.3_FaliES1 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000352.1:11200-11907:- | gene-YJR050W_JAY291 | rna-NM_001181708.3_JAY291 | cds-NP_012584.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:514723-515430:+ | gene-YJR050W_MUCL30387 | rna-NM_001181708.3_MUCL30387 | cds-NP_012584.3_MUCL30387 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:511276-511983:+ | gene-YJR050W_MUCL30388 | rna-NM_001181708.3_MUCL30388 | cds-NP_012584.3_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:505912-506619:+ | gene-YJR050W_MUCL39482 | rna-NM_001181708.3_MUCL39482 | cds-NP_012584.3_MUCL39482 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:510683-511390:+ | gene-YJR050W_MUCL42920 | rna-NM_001181708.3_MUCL42920 | cds-NP_012584.3_MUCL42920 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:528676-529383:+ | gene-YJR050W_NCIM3186 | rna-NM_001181708.3_NCIM3186 | cds-NP_012584.3_NCIM3186 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:503769-504476:+ | gene-YJR050W_NCYC1407 | rna-NM_001181708.3_NCYC1407 | cds-NP_012584.3_NCYC1407 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:521666-522373:+ | gene-YJR050W_PE2H3 | rna-NM_001181708.3_PE2H3 | cds-NP_012584.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:515362-516069:+ | gene-YJR050W_PE2H4 | rna-NM_001181708.3_PE2H4 | cds-NP_012584.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:528697-529404:+ | gene-YJR050W_S288C | rna-NM_001181708.3_S288C | cds-NP_012584.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000110.1:10265-10972:+ | gene-YJR050W_SA1 | rna-NM_001181708.3_SA1 | cds-NP_012584.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:510201-510908:+ | gene-YJR050W_ThermosaccDry | rna-NM_001181708.3_ThermosaccDry | cds-NP_012584.3_ThermosaccDry | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:512699-513406:+ | gene-YJR050W_VR1 | rna-NM_001181708.3_VR1 | cds-NP_012584.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:490084-490791:+ | gene-YJR050W_ZTW1 | rna-NM_001181708.3_ZTW1 | cds-NP_012584.3_ZTW1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:516416-517123:+ | gene-YJR050W_Sparadoxus | rna-NM_001181708.3_Sparadoxus | cds-NP_012584.3_Sparadoxus | 88.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |