Gene name: ISU2
Reference locus (S288C): YOR226C
Gene biotype: protein_coding
Description: Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant
Top 10 interactors (score): JAC1 (0.999); NFS1 (0.999); ISD11 (0.998); NFU1 (0.995); YFH1 (0.992); GRX5 (0.988); YAH1 (0.974); ISA2 (0.961); SSQ1 (0.956); ISA1 (0.953); LIP5 (0.914); IBA57 (0.914); MRS4 (0.894); ARH1 (0.889); MRS3 (0.885); MGE1 (0.858); ATM1 (0.854); ACP1 (0.844); NBP35 (0.797); BIO2 (0.791)
Homologues (species, bitscore): ISCU (Homo sapiens, 200.7); Iscu (Mus musculus, 198.0); iscub (Danio rerio, 201.1); iscu (Xenopus tropicalis, 193.0); CG9836 (Drosophila melanogaster, 190.7); Y45F10D.4 (Caenorhabditis elegans, 188.7); ISU1 (Arabidopsis thaliana, 198.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:752397-752867:- | gene-YOR226C_AKU4011 | rna-NM_001183645.3_AKU4011 | cds-NP_014869.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:154429-154899:- | gene-YOR226C_BG1 | rna-NM_001183645.3_BG1 | cds-NP_014869.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:737859-738329:- | gene-YOR226C_Bruggeman | rna-NM_001183645.3_Bruggeman | cds-NP_014869.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:738506-738976:- | gene-YOR226C_CAT1 | rna-NM_001183645.3_CAT1 | cds-NP_014869.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:735383-735853:- | gene-YOR226C_CBS1585 | rna-NM_001183645.3_CBS1585 | cds-NP_014869.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:734071-734541:- | gene-YOR226C_CBS436 | rna-NM_001183645.3_CBS436 | cds-NP_014869.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:732503-732973:- | gene-YOR226C_CBS6412 | rna-NM_001183645.3_CBS6412 | cds-NP_014869.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:741142-741612:- | gene-YOR226C_CBS6413 | rna-NM_001183645.3_CBS6413 | cds-NP_014869.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:761381-761851:- | gene-YOR226C_CENPK1137D | rna-NM_001183645.3_CENPK1137D | cds-NP_014869.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:728534-729004:- | gene-YOR226C_EthanolRed | rna-NM_001183645.3_EthanolRed | cds-NP_014869.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:733931-734401:- | gene-YOR226C_FaliES1 | rna-NM_001183645.3_FaliES1 | cds-NP_014869.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:92362-92832:+ | gene-YOR226C_JAY291 | rna-NM_001183645.3_JAY291 | cds-NP_014869.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:741196-741666:- | gene-YOR226C_MUCL30387 | rna-NM_001183645.3_MUCL30387 | cds-NP_014869.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:748615-749085:- | gene-YOR226C_MUCL30388 | rna-NM_001183645.3_MUCL30388 | cds-NP_014869.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:742713-743183:- | gene-YOR226C_MUCL39482 | rna-NM_001183645.3_MUCL39482 | cds-NP_014869.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:752293-752763:- | gene-YOR226C_MUCL42920 | rna-NM_001183645.3_MUCL42920 | cds-NP_014869.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:761503-761973:- | gene-YOR226C_NCIM3186 | rna-NM_001183645.3_NCIM3186 | cds-NP_014869.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:742815-743285:- | gene-YOR226C_NCYC1407 | rna-NM_001183645.3_NCYC1407 | cds-NP_014869.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:742204-742674:- | gene-YOR226C_PE2H3 | rna-NM_001183645.3_PE2H3 | cds-NP_014869.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:752581-753051:- | gene-YOR226C_PE2H4 | rna-NM_001183645.3_PE2H4 | cds-NP_014869.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:761614-762084:- | gene-YOR226C_S288C | rna-NM_001183645.3_S288C | cds-NP_014869.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:171611-172081:- | gene-YOR226C_SA1 | rna-NM_001183645.3_SA1 | cds-NP_014869.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:733116-733586:- | gene-YOR226C_ThermosaccDry | rna-NM_001183645.3_ThermosaccDry | cds-NP_014869.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:796645-797115:- | gene-YOR226C_VR1 | rna-NM_001183645.3_VR1 | cds-NP_014869.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:466015-466485:- | gene-YOR226C_ZTW1 | rna-NM_001183645.3_ZTW1 | cds-NP_014869.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:738976-739446:- | gene-YOR226C_Sparadoxus | rna-NM_001183645.3_Sparadoxus | cds-NP_014869.3_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |