Gene name: ISU1
Reference locus (S288C): YPL135W
Gene biotype: protein_coding
Description: Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant; Belongs to the NifU family
Top 10 interactors (score): YFH1 (0.999); JAC1 (0.999); YAH1 (0.999); ISD11 (0.999); NFS1 (0.999); SSQ1 (0.998); GRX5 (0.997); NFU1 (0.996); ISA1 (0.983); ISA2 (0.981); IBA57 (0.962); ATM1 (0.937); LIP5 (0.918); MGE1 (0.915); NBP35 (0.9); MRS4 (0.899); GRX3 (0.887); MRS3 (0.885); NAR1 (0.879); SDH2 (0.868)
Homologues (species, bitscore): ISCU (Homo sapiens, 193.0); Iscu (Mus musculus, 193.7); iscub (Danio rerio, 193.4); iscu (Xenopus tropicalis, 188.3); CG9836 (Drosophila melanogaster, 197.2); Y45F10D.4 (Caenorhabditis elegans, 192.2); ISU1 (Arabidopsis thaliana, 203.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:275207-275704:+ | gene-YPL135W_AKU4011 | rna-NM_001183949.1_AKU4011 | cds-NP_015190.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:480894-481391:+ | gene-YPL135W_BG1 | rna-NM_001183949.1_BG1 | cds-NP_015190.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:301202-301699:+ | gene-YPL135W_Bruggeman | rna-NM_001183949.1_Bruggeman | cds-NP_015190.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:297880-298377:+ | gene-YPL135W_CAT1 | rna-NM_001183949.1_CAT1 | cds-NP_015190.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:279274-279771:+ | gene-YPL135W_CBS1585 | rna-NM_001183949.1_CBS1585 | cds-NP_015190.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:293944-294441:+ | gene-YPL135W_CBS436 | rna-NM_001183949.1_CBS436 | cds-NP_015190.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:283949-284446:+ | gene-YPL135W_CBS6412 | rna-NM_001183949.1_CBS6412 | cds-NP_015190.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:275912-276409:+ | gene-YPL135W_CBS6413 | rna-NM_001183949.1_CBS6413 | cds-NP_015190.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:297455-297952:+ | gene-YPL135W_CENPK1137D | rna-NM_001183949.1_CENPK1137D | cds-NP_015190.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:273893-274390:+ | gene-YPL135W_EthanolRed | rna-NM_001183949.1_EthanolRed | cds-NP_015190.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:281485-281982:+ | gene-YPL135W_FaliES1 | rna-NM_001183949.1_FaliES1 | cds-NP_015190.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:83862-84359:- | gene-YPL135W_JAY291 | rna-NM_001183949.1_JAY291 | cds-NP_015190.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:292446-292943:+ | gene-YPL135W_MUCL30387 | rna-NM_001183949.1_MUCL30387 | cds-NP_015190.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:290460-290957:+ | gene-YPL135W_MUCL30388 | rna-NM_001183949.1_MUCL30388 | cds-NP_015190.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:272603-273100:+ | gene-YPL135W_MUCL39482 | rna-NM_001183949.1_MUCL39482 | cds-NP_015190.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:329844-330341:+ | gene-YPL135W_MUCL42920 | rna-NM_001183949.1_MUCL42920 | cds-NP_015190.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:297536-298033:+ | gene-YPL135W_NCIM3186 | rna-NM_001183949.1_NCIM3186 | cds-NP_015190.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:279062-279559:+ | gene-YPL135W_NCYC1407 | rna-NM_001183949.1_NCYC1407 | cds-NP_015190.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:286518-287015:+ | gene-YPL135W_PE2H3 | rna-NM_001183949.1_PE2H3 | cds-NP_015190.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:286144-286641:+ | gene-YPL135W_PE2H4 | rna-NM_001183949.1_PE2H4 | cds-NP_015190.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:297553-298050:+ | gene-YPL135W_S288C | rna-NM_001183949.1_S288C | cds-NP_015190.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:75632-76129:- | gene-YPL135W_SA1 | rna-NM_001183949.1_SA1 | cds-NP_015190.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:281283-281780:+ | gene-YPL135W_ThermosaccDry | rna-NM_001183949.1_ThermosaccDry | cds-NP_015190.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:296265-296762:+ | gene-YPL135W_VR1 | rna-NM_001183949.1_VR1 | cds-NP_015190.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:280613-281110:+ | gene-YPL135W_ZTW1 | rna-NM_001183949.1_ZTW1 | cds-NP_015190.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:282319-282816:+ | gene-YPL135W_Sparadoxus | rna-NM_001183949.1_Sparadoxus | cds-NP_015190.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |