Gene name: IST2
Reference locus (S288C): YBR086C
Gene biotype: protein_coding
Description: Increased sodium tolerance protein 2; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
Top 10 interactors (score): SCS2 (0.971); SHE2 (0.94); TCB1 (0.931); CWC2 (0.918); TCB3 (0.917); SCS22 (0.898); TCB2 (0.881); SAC1 (0.864); OSH6 (0.857); YHC3 (0.811); SHE3 (0.79); MYO4 (0.784); ASH1 (0.78); HEK2 (0.726); PHO88 (0.721); BTN2 (0.704); MMR1 (0.67); SUA7 (0.658); SEC61 (0.626); EAR1 (0.618)
Homologues (species, bitscore): ANO10 (Homo sapiens, 53.1); ano10 (Xenopus tropicalis, 51.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:402573-405410:- | gene-YBR086C_AKU4011 | rna-NM_001178434.1_AKU4011 | cds-NP_009643.2_AKU4011 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:393614-396448:- | gene-YBR086C_BG1 | rna-NM_001178434.1_BG1 | cds-NP_009643.2_BG1 | 99.4 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:404148-406985:- | gene-YBR086C_Bruggeman | rna-NM_001178434.1_Bruggeman | cds-NP_009643.2_Bruggeman | 99.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:407122-409959:- | gene-YBR086C_CAT1 | rna-NM_001178434.1_CAT1 | cds-NP_009643.2_CAT1 | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:394858-397695:- | gene-YBR086C_CBS1585 | rna-NM_001178434.1_CBS1585 | cds-NP_009643.2_CBS1585 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:402962-405814:- | gene-YBR086C_CBS436 | rna-NM_001178434.1_CBS436 | cds-NP_009643.2_CBS436 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:493087-495924:- | gene-YBR086C_CBS6412 | rna-NM_001178434.1_CBS6412 | cds-NP_009643.2_CBS6412 | 99.6 | 99.8 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:399998-402835:- | gene-YBR086C_CBS6413 | rna-NM_001178434.1_CBS6413 | cds-NP_009643.2_CBS6413 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:413953-416793:- | gene-YBR086C_CENPK1137D | rna-NM_001178434.1_CENPK1137D | cds-NP_009643.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:529364-532201:- | gene-YBR086C_EthanolRed | rna-NM_001178434.1_EthanolRed | cds-NP_009643.2_EthanolRed | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:418647-421484:- | gene-YBR086C_FaliES1 | rna-NM_001178434.1_FaliES1 | cds-NP_009643.2_FaliES1 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000013.1:5698-8550:+ | gene-YBR086C_JAY291 | rna-NM_001178434.1_JAY291 | cds-NP_009643.2_JAY291 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:406385-409222:- | gene-YBR086C_MUCL30387 | rna-NM_001178434.1_MUCL30387 | cds-NP_009643.2_MUCL30387 | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:405380-408217:- | gene-YBR086C_MUCL30388 | rna-NM_001178434.1_MUCL30388 | cds-NP_009643.2_MUCL30388 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:394849-397686:- | gene-YBR086C_MUCL39482 | rna-NM_001178434.1_MUCL39482 | cds-NP_009643.2_MUCL39482 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:402062-404899:- | gene-YBR086C_MUCL42920 | rna-NM_001178434.1_MUCL42920 | cds-NP_009643.2_MUCL42920 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:419998-422838:- | gene-YBR086C_NCIM3186 | rna-NM_001178434.1_NCIM3186 | cds-NP_009643.2_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:395781-398618:- | gene-YBR086C_NCYC1407 | rna-NM_001178434.1_NCYC1407 | cds-NP_009643.2_NCYC1407 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:408380-411232:- | gene-YBR086C_PE2H3 | rna-NM_001178434.1_PE2H3 | cds-NP_009643.2_PE2H3 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:406056-408908:- | gene-YBR086C_PE2H4 | rna-NM_001178434.1_PE2H4 | cds-NP_009643.2_PE2H4 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:420201-423041:- | gene-YBR086C_S288C | rna-NM_001178434.1_S288C | cds-NP_009643.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000017.1:54661-57498:+ | gene-YBR086C_SA1 | rna-NM_001178434.1_SA1 | cds-NP_009643.2_SA1 | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:417654-420491:- | gene-YBR086C_ThermosaccDry | rna-NM_001178434.1_ThermosaccDry | cds-NP_009643.2_ThermosaccDry | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:399641-402493:- | gene-YBR086C_VR1 | rna-NM_001178434.1_VR1 | cds-NP_009643.2_VR1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:393320-396157:- | gene-YBR086C_ZTW1 | rna-NM_001178434.1_ZTW1 | cds-NP_009643.2_ZTW1 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:430201-433020:- | gene-YBR086C_Sparadoxus | rna-NM_001178434.1_Sparadoxus | cds-NP_009643.2_Sparadoxus | 87.7 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |