Gene name: ISR1
Reference locus (S288C): YPR106W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase ISR1; Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
Top 10 interactors (score): ALK1 (0.77); IKS1 (0.696); PHO85 (0.688); SCY1 (0.675); HAL5 (0.675); MCP2 (0.654); KKQ8 (0.651); CHS2 (0.641); ATC1 (0.618); FMP48 (0.617); YPL150W (0.616); GCN1 (0.615); CDC4 (0.609); TOS3 (0.569); PKC1 (0.565); BUD32 (0.563); KNS1 (0.562); PAN3 (0.53); SPS1 (0.528); TDA1 (0.525)
Homologues (species, bitscore): PASK (Homo sapiens, 55.8); Pask (Mus musculus, 60.5); stk25b (Danio rerio, 53.1); PASK (Xenopus tropicalis, 68.9); Mekk1 (Drosophila melanogaster, 53.9); lin-45 (Caenorhabditis elegans, 57.0); RUK (Arabidopsis thaliana, 53.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:711897-713228:+ | gene-YPR106W_AKU4011 | rna-NM_001184203.1_AKU4011 | cds-NP_015431.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:184615-185946:- | gene-YPR106W_BG1 | rna-NM_001184203.1_BG1 | cds-NP_015431.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:789906-791237:+ | gene-YPR106W_Bruggeman | rna-NM_001184203.1_Bruggeman | cds-NP_015431.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:834206-835537:+ | gene-YPR106W_CAT1 | rna-NM_001184203.1_CAT1 | cds-NP_015431.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:716154-717485:+ | gene-YPR106W_CBS1585 | rna-NM_001184203.1_CBS1585 | cds-NP_015431.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:730448-731779:+ | gene-YPR106W_CBS436 | rna-NM_001184203.1_CBS436 | cds-NP_015431.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:718390-719721:+ | gene-YPR106W_CBS6412 | rna-NM_001184203.1_CBS6412 | cds-NP_015431.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:713111-714442:+ | gene-YPR106W_CBS6413 | rna-NM_001184203.1_CBS6413 | cds-NP_015431.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:740046-741377:+ | gene-YPR106W_CENPK1137D | rna-NM_001184203.1_CENPK1137D | cds-NP_015431.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1038511-1039842:+ | gene-YPR106W_EthanolRed | rna-NM_001184203.1_EthanolRed | cds-NP_015431.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:718058-719389:+ | gene-YPR106W_FaliES1 | rna-NM_001184203.1_FaliES1 | cds-NP_015431.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000436.1:8817-10148:+ | gene-YPR106W_JAY291 | rna-NM_001184203.1_JAY291 | cds-NP_015431.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:731164-732495:+ | gene-YPR106W_MUCL30387 | rna-NM_001184203.1_MUCL30387 | cds-NP_015431.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:729854-731185:+ | gene-YPR106W_MUCL30388 | rna-NM_001184203.1_MUCL30388 | cds-NP_015431.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:708661-709992:+ | gene-YPR106W_MUCL39482 | rna-NM_001184203.1_MUCL39482 | cds-NP_015431.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:771756-773087:+ | gene-YPR106W_MUCL42920 | rna-NM_001184203.1_MUCL42920 | cds-NP_015431.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:740044-741375:+ | gene-YPR106W_NCIM3186 | rna-NM_001184203.1_NCIM3186 | cds-NP_015431.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:717255-718586:+ | gene-YPR106W_NCYC1407 | rna-NM_001184203.1_NCYC1407 | cds-NP_015431.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:723492-724823:+ | gene-YPR106W_PE2H3 | rna-NM_001184203.1_PE2H3 | cds-NP_015431.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:723140-724471:+ | gene-YPR106W_PE2H4 | rna-NM_001184203.1_PE2H4 | cds-NP_015431.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:740061-741392:+ | gene-YPR106W_S288C | rna-NM_001184203.1_S288C | cds-NP_015431.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000028.1:38180-39511:+ | gene-YPR106W_SA1 | rna-NM_001184203.1_SA1 | cds-NP_015431.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:717503-718834:+ | gene-YPR106W_ThermosaccDry | rna-NM_001184203.1_ThermosaccDry | cds-NP_015431.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:734159-735490:+ | gene-YPR106W_VR1 | rna-NM_001184203.1_VR1 | cds-NP_015431.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:716553-717884:+ | gene-YPR106W_ZTW1 | rna-NM_001184203.1_ZTW1 | cds-NP_015431.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:717487-718818:+ | gene-YPR106W_Sparadoxus | rna-NM_001184203.1_Sparadoxus | cds-NP_015431.1_Sparadoxus | 87.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |