Gene name: ISM1
Reference locus (S288C): YPL040C
Gene biotype: protein_coding
Description: Isoleucine--tRNA ligase, mitochondrial; Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant
Top 10 interactors (score): CDC60 (0.985); AIM10 (0.975); NAM2 (0.972); YNL247W (0.958); GLN4 (0.944); MSE1 (0.939); MSY1 (0.929); YHR020W (0.917); MSR1 (0.912); TYS1 (0.903); THS1 (0.9); MST1 (0.899); YDR341C (0.896); MSF1 (0.889); SLM5 (0.885); ALA1 (0.864); ILS1 (0.858); MSW1 (0.856); SES1 (0.85); MSD1 (0.845)
Homologues (species, bitscore): IARS2 (Homo sapiens, 603.6); Iars2 (Mus musculus, 600.9); iars2 (Danio rerio, 588.2); iars2 (Xenopus tropicalis, 549.7); CG5414 (Drosophila melanogaster, 525.8); iars-2 (Caenorhabditis elegans, 434.1); OVA2 (Arabidopsis thaliana, 637.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:447492-450500:- | gene-YPL040C_AKU4011 | rna-NM_001183854.1_AKU4011 | cds-NP_015285.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:446940-449948:+ | gene-YPL040C_BG1 | rna-NM_001183854.1_BG1 | cds-NP_015285.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:524435-527443:- | gene-YPL040C_Bruggeman | rna-NM_001183854.1_Bruggeman | cds-NP_015285.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:564122-567130:- | gene-YPL040C_CAT1 | rna-NM_001183854.1_CAT1 | cds-NP_015285.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:451560-454568:- | gene-YPL040C_CBS1585 | rna-NM_001183854.1_CBS1585 | cds-NP_015285.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:465680-468688:- | gene-YPL040C_CBS436 | rna-NM_001183854.1_CBS436 | cds-NP_015285.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:455752-458760:- | gene-YPL040C_CBS6412 | rna-NM_001183854.1_CBS6412 | cds-NP_015285.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:448112-451120:- | gene-YPL040C_CBS6413 | rna-NM_001183854.1_CBS6413 | cds-NP_015285.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:475970-478978:- | gene-YPL040C_CENPK1137D | rna-NM_001183854.1_CENPK1137D | cds-NP_015285.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:445849-448857:- | gene-YPL040C_EthanolRed | rna-NM_001183854.1_EthanolRed | cds-NP_015285.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:453679-456687:- | gene-YPL040C_FaliES1 | rna-NM_001183854.1_FaliES1 | cds-NP_015285.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000283.1:62269-65277:- | gene-YPL040C_JAY291 | rna-NM_001183854.1_JAY291 | cds-NP_015285.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:465369-468377:- | gene-YPL040C_MUCL30387 | rna-NM_001183854.1_MUCL30387 | cds-NP_015285.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:464510-467518:- | gene-YPL040C_MUCL30388 | rna-NM_001183854.1_MUCL30388 | cds-NP_015285.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:444876-447884:- | gene-YPL040C_MUCL39482 | rna-NM_001183854.1_MUCL39482 | cds-NP_015285.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:503473-506481:- | gene-YPL040C_MUCL42920 | rna-NM_001183854.1_MUCL42920 | cds-NP_015285.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:475976-478984:- | gene-YPL040C_NCIM3186 | rna-NM_001183854.1_NCIM3186 | cds-NP_015285.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:452156-455164:- | gene-YPL040C_NCYC1407 | rna-NM_001183854.1_NCYC1407 | cds-NP_015285.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:458763-461771:- | gene-YPL040C_PE2H3 | rna-NM_001183854.1_PE2H3 | cds-NP_015285.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:458378-461386:- | gene-YPL040C_PE2H4 | rna-NM_001183854.1_PE2H4 | cds-NP_015285.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:475993-479001:- | gene-YPL040C_S288C | rna-NM_001183854.1_S288C | cds-NP_015285.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000077.1:13824-16832:- | gene-YPL040C_SA1 | rna-NM_001183854.1_SA1 | cds-NP_015285.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:453478-456486:- | gene-YPL040C_ThermosaccDry | rna-NM_001183854.1_ThermosaccDry | cds-NP_015285.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:468367-471375:- | gene-YPL040C_VR1 | rna-NM_001183854.1_VR1 | cds-NP_015285.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:452780-455788:- | gene-YPL040C_ZTW1 | rna-NM_001183854.1_ZTW1 | cds-NP_015285.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:452772-455780:- | gene-YPL040C_Sparadoxus | rna-NM_001183854.1_Sparadoxus | cds-NP_015285.1_Sparadoxus | 88.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |