Gene name: ISD11
Reference locus (S288C): YER048W-A
Gene biotype: protein_coding
Description: Protein ISD11; Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family
Top 10 interactors (score): ACP1 (0.999); ISU1 (0.999); NFS1 (0.999); YFH1 (0.999); YAH1 (0.998); ISU2 (0.998); JAC1 (0.992); IBA57 (0.988); NFU1 (0.988); GRX5 (0.985); SSQ1 (0.97); ISA2 (0.964); SDH7 (0.964); NBP35 (0.956); MGE1 (0.95); ISA1 (0.947); SSC1 (0.923); LIP5 (0.922); ATM1 (0.922); NAR1 (0.916)
Homologues (species, bitscore): LYRM4 (Homo sapiens, 66.2); Lyrm4 (Mus musculus, 73.6); lyrm4 (Danio rerio, 68.2); bcn92 (Drosophila melanogaster, 62.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:244519-244803:+ | gene-YER048W-A_AKU4011 | rna-NM_001184330.1_AKU4011 | cds-NP_010968.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:181002-181286:- | gene-YER048W-A_BG1 | rna-NM_001184330.1_BG1 | cds-NP_010968.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:253312-253596:+ | gene-YER048W-A_Bruggeman | rna-NM_001184330.1_Bruggeman | cds-NP_010968.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:247460-247744:+ | gene-YER048W-A_CAT1 | rna-NM_001184330.1_CAT1 | cds-NP_010968.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:244364-244648:+ | gene-YER048W-A_CBS1585 | rna-NM_001184330.1_CBS1585 | cds-NP_010968.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:246282-246566:+ | gene-YER048W-A_CBS436 | rna-NM_001184330.1_CBS436 | cds-NP_010968.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:243833-244117:+ | gene-YER048W-A_CBS6412 | rna-NM_001184330.1_CBS6412 | cds-NP_010968.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:249858-250142:+ | gene-YER048W-A_CBS6413 | rna-NM_001184330.1_CBS6413 | cds-NP_010968.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:248580-248864:+ | gene-YER048W-A_CENPK1137D | rna-NM_001184330.1_CENPK1137D | cds-NP_010968.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:244845-245129:+ | gene-YER048W-A_EthanolRed | rna-NM_001184330.1_EthanolRed | cds-NP_010968.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:245315-245599:+ | gene-YER048W-A_FaliES1 | rna-NM_001184330.1_FaliES1 | cds-NP_010968.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000192.1:43074-43358:+ | gene-YER048W-A_JAY291 | rna-NM_001184330.1_JAY291 | cds-NP_010968.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:248770-249054:+ | gene-YER048W-A_MUCL30387 | rna-NM_001184330.1_MUCL30387 | cds-NP_010968.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:244939-245223:+ | gene-YER048W-A_MUCL30388 | rna-NM_001184330.1_MUCL30388 | cds-NP_010968.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:243387-243671:+ | gene-YER048W-A_MUCL39482 | rna-NM_001184330.1_MUCL39482 | cds-NP_010968.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:250453-250737:+ | gene-YER048W-A_MUCL42920 | rna-NM_001184330.1_MUCL42920 | cds-NP_010968.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:250717-251001:+ | gene-YER048W-A_NCIM3186 | rna-NM_001184330.1_NCIM3186 | cds-NP_010968.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:248468-248752:+ | gene-YER048W-A_NCYC1407 | rna-NM_001184330.1_NCYC1407 | cds-NP_010968.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:259099-259383:+ | gene-YER048W-A_PE2H3 | rna-NM_001184330.1_PE2H3 | cds-NP_010968.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:249040-249324:+ | gene-YER048W-A_PE2H4 | rna-NM_001184330.1_PE2H4 | cds-NP_010968.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:250718-251002:+ | gene-YER048W-A_S288C | rna-NM_001184330.1_S288C | cds-NP_010968.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000059.1:37186-37470:+ | gene-YER048W-A_SA1 | rna-NM_001184330.1_SA1 | cds-NP_010968.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:246104-246388:+ | gene-YER048W-A_ThermosaccDry | rna-NM_001184330.1_ThermosaccDry | cds-NP_010968.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:245176-245460:+ | gene-YER048W-A_VR1 | rna-NM_001184330.1_VR1 | cds-NP_010968.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:243294-243578:+ | gene-YER048W-A_ZTW1 | rna-NM_001184330.1_ZTW1 | cds-NP_010968.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:247123-247407:+ | gene-YER048W-A_Sparadoxus | rna-NM_001184330.1_Sparadoxus | cds-NP_010968.1_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |