Gene name: ISC1
Reference locus (S288C): YER019W
Gene biotype: protein_coding
Description: Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; ortholog of mammalian neutral sphingomyelinase type 2
Top 10 interactors (score): YPC1 (0.992); YDC1 (0.991); HSP60 (0.978); PLC1 (0.969); TCM62 (0.963); RFC5 (0.962); LCB1 (0.956); SIT4 (0.909); LAG1 (0.907); LAC1 (0.901); SCH9 (0.881); LCB4 (0.866); LCB2 (0.865); PFK26 (0.835); FBP26 (0.835); YSR3 (0.833); SWE1 (0.824); IPT1 (0.823); DPL1 (0.823); AUR1 (0.801)
Homologues (species, bitscore): SMPD2 (Homo sapiens, 129.8); Smpd2 (Mus musculus, 131.0); LOC797914 (Danio rerio, 142.1); smpd2 (Xenopus tropicalis, 121.7); CG12034 (Drosophila melanogaster, 126.3); T27F6.6 (Caenorhabditis elegans, 145.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:186831-188264:+ | gene-YER019W_AKU4011 | rna-NM_001178910.1_AKU4011 | cds-NP_010935.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:237828-239261:- | gene-YER019W_BG1 | rna-NM_001178910.1_BG1 | cds-NP_010935.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:194687-196120:+ | gene-YER019W_Bruggeman | rna-NM_001178910.1_Bruggeman | cds-NP_010935.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:189577-191010:+ | gene-YER019W_CAT1 | rna-NM_001178910.1_CAT1 | cds-NP_010935.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:186754-188187:+ | gene-YER019W_CBS1585 | rna-NM_001178910.1_CBS1585 | cds-NP_010935.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:188339-189772:+ | gene-YER019W_CBS436 | rna-NM_001178910.1_CBS436 | cds-NP_010935.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:186998-188431:+ | gene-YER019W_CBS6412 | rna-NM_001178910.1_CBS6412 | cds-NP_010935.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:191784-193217:+ | gene-YER019W_CBS6413 | rna-NM_001178910.1_CBS6413 | cds-NP_010935.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:190686-192119:+ | gene-YER019W_CENPK1137D | rna-NM_001178910.1_CENPK1137D | cds-NP_010935.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:187457-188890:+ | gene-YER019W_EthanolRed | rna-NM_001178910.1_EthanolRed | cds-NP_010935.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:187717-189150:+ | gene-YER019W_FaliES1 | rna-NM_001178910.1_FaliES1 | cds-NP_010935.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000024.1:54339-55772:+ | gene-YER019W_JAY291 | rna-NM_001178910.1_JAY291 | cds-NP_010935.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:190897-192330:+ | gene-YER019W_MUCL30387 | rna-NM_001178910.1_MUCL30387 | cds-NP_010935.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:187133-188566:+ | gene-YER019W_MUCL30388 | rna-NM_001178910.1_MUCL30388 | cds-NP_010935.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:185797-187230:+ | gene-YER019W_MUCL39482 | rna-NM_001178910.1_MUCL39482 | cds-NP_010935.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:191911-193344:+ | gene-YER019W_MUCL42920 | rna-NM_001178910.1_MUCL42920 | cds-NP_010935.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:192796-194229:+ | gene-YER019W_NCIM3186 | rna-NM_001178910.1_NCIM3186 | cds-NP_010935.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:190869-192302:+ | gene-YER019W_NCYC1407 | rna-NM_001178910.1_NCYC1407 | cds-NP_010935.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:195181-196614:+ | gene-YER019W_PE2H3 | rna-NM_001178910.1_PE2H3 | cds-NP_010935.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:191080-192513:+ | gene-YER019W_PE2H4 | rna-NM_001178910.1_PE2H4 | cds-NP_010935.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:192797-194230:+ | gene-YER019W_S288C | rna-NM_001178910.1_S288C | cds-NP_010935.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:49456-50889:- | gene-YER019W_SA1 | rna-NM_001178910.1_SA1 | cds-NP_010935.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:188488-189921:+ | gene-YER019W_ThermosaccDry | rna-NM_001178910.1_ThermosaccDry | cds-NP_010935.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:187240-188673:+ | gene-YER019W_VR1 | rna-NM_001178910.1_VR1 | cds-NP_010935.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:185700-187133:+ | gene-YER019W_ZTW1 | rna-NM_001178910.1_ZTW1 | cds-NP_010935.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:189456-190886:+ | gene-YER019W_Sparadoxus | rna-NM_001178910.1_Sparadoxus | cds-NP_010935.1_Sparadoxus | 88.8 | 99.5 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |