Gene name: ISA1
Reference locus (S288C): YLL027W
Gene biotype: protein_coding
Description: Iron-sulfur assembly protein 1; Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant
Top 10 interactors (score): GRX5 (0.999); ISA2 (0.999); IBA57 (0.998); JAC1 (0.996); NFU1 (0.996); YAH1 (0.989); NFS1 (0.984); ISU1 (0.983); LIP5 (0.978); ATM1 (0.974); YFH1 (0.964); ISU2 (0.953); ISD11 (0.947); BIO2 (0.922); NAR1 (0.919); BOL3 (0.905); HEM15 (0.903); MGE1 (0.895); BOL1 (0.888); SSQ1 (0.874)
Homologues (species, bitscore): ISCA1 (Homo sapiens, 133.3); Isca1 (Mus musculus, 134.0); isca1 (Danio rerio, 121.3); ISCA1 (Xenopus tropicalis, 130.2); l(1)G0136 (Drosophila melanogaster, 126.3); Y39B6A.3 (Caenorhabditis elegans, 130.2); AT2G16710 (Arabidopsis thaliana, 124.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:74565-75317:+ | gene-YLL027W_AKU4011 | rna-NM_001181847.1_AKU4011 | cds-NP_013073.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:38512-39264:+ | gene-YLL027W_BG1 | rna-NM_001181847.1_BG1 | cds-NP_013073.1_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:84819-85571:+ | gene-YLL027W_Bruggeman | rna-NM_001181847.1_Bruggeman | cds-NP_013073.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:85436-86188:+ | gene-YLL027W_CAT1 | rna-NM_001181847.1_CAT1 | cds-NP_013073.1_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:82263-83015:+ | gene-YLL027W_CBS1585 | rna-NM_001181847.1_CBS1585 | cds-NP_013073.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:72464-73216:+ | gene-YLL027W_CBS436 | rna-NM_001181847.1_CBS436 | cds-NP_013073.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:82180-82932:+ | gene-YLL027W_CBS6412 | rna-NM_001181847.1_CBS6412 | cds-NP_013073.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:82272-83024:+ | gene-YLL027W_CBS6413 | rna-NM_001181847.1_CBS6413 | cds-NP_013073.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:72408-73160:+ | gene-YLL027W_CENPK1137D | rna-NM_001181847.1_CENPK1137D | cds-NP_013073.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:74959-75711:+ | gene-YLL027W_EthanolRed | rna-NM_001181847.1_EthanolRed | cds-NP_013073.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:74273-75025:+ | gene-YLL027W_FaliES1 | rna-NM_001181847.1_FaliES1 | cds-NP_013073.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000118.1:3980-4732:- | gene-YLL027W_JAY291 | rna-NM_001181847.1_JAY291 | cds-NP_013073.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:82233-82985:+ | gene-YLL027W_MUCL30387 | rna-NM_001181847.1_MUCL30387 | cds-NP_013073.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:86959-87711:+ | gene-YLL027W_MUCL30388 | rna-NM_001181847.1_MUCL30388 | cds-NP_013073.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:82472-83224:+ | gene-YLL027W_MUCL39482 | rna-NM_001181847.1_MUCL39482 | cds-NP_013073.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:82569-83321:+ | gene-YLL027W_MUCL42920 | rna-NM_001181847.1_MUCL42920 | cds-NP_013073.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:87377-88129:+ | gene-YLL027W_NCIM3186 | rna-NM_001181847.1_NCIM3186 | cds-NP_013073.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:74356-75108:+ | gene-YLL027W_NCYC1407 | rna-NM_001181847.1_NCYC1407 | cds-NP_013073.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:81023-81775:+ | gene-YLL027W_PE2H3 | rna-NM_001181847.1_PE2H3 | cds-NP_013073.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:80831-81583:+ | gene-YLL027W_PE2H4 | rna-NM_001181847.1_PE2H4 | cds-NP_013073.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:87403-88155:+ | gene-YLL027W_S288C | rna-NM_001181847.1_S288C | cds-NP_013073.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:80991-81743:+ | gene-YLL027W_SA1 | rna-NM_001181847.1_SA1 | cds-NP_013073.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:74779-75531:+ | gene-YLL027W_ThermosaccDry | rna-NM_001181847.1_ThermosaccDry | cds-NP_013073.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:88841-89593:+ | gene-YLL027W_VR1 | rna-NM_001181847.1_VR1 | cds-NP_013073.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:74349-75101:+ | gene-YLL027W_ZTW1 | rna-NM_001181847.1_ZTW1 | cds-NP_013073.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:82914-83666:+ | gene-YLL027W_Sparadoxus | rna-NM_001181847.1_Sparadoxus | cds-NP_013073.1_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |