Gene name: IRS4
Reference locus (S288C): YKR019C
Gene biotype: protein_coding
Description: Increased rDNA silencing protein 4; EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
Top 10 interactors (score): INP51 (0.993); APL3 (0.924); ENT4 (0.78); SLG1 (0.78); SEC4 (0.772); YAP1801 (0.768); APM4 (0.752); UBP16 (0.745); VPS27 (0.742); TAX4 (0.727); ENT1 (0.695); YAP1802 (0.694); RVS161 (0.692); INP52 (0.685); INP53 (0.677); CHC1 (0.674); HOF1 (0.659); ENT3 (0.656); VPS1 (0.654); DNM1 (0.654)
Homologues (species, bitscore): ITSN2 (Homo sapiens, 52.4); Itsn2 (Mus musculus, 51.6); eps15 (Danio rerio, 52.8); eps15 (Xenopus tropicalis, 52.8); Eps-15 (Drosophila melanogaster, 55.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:461885-463732:- | gene-YKR019C_AKU4011 | rna-NM_001179809.3_AKU4011 | cds-NP_012944.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:179768-181615:+ | gene-YKR019C_BG1 | rna-NM_001179809.3_BG1 | cds-NP_012944.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:483558-485405:- | gene-YKR019C_Bruggeman | rna-NM_001179809.3_Bruggeman | cds-NP_012944.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:479299-481146:- | gene-YKR019C_CAT1 | rna-NM_001179809.3_CAT1 | cds-NP_012944.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:474625-476472:- | gene-YKR019C_CBS1585 | rna-NM_001179809.3_CBS1585 | cds-NP_012944.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:473456-475303:- | gene-YKR019C_CBS436 | rna-NM_001179809.3_CBS436 | cds-NP_012944.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:458786-460633:- | gene-YKR019C_CBS6412 | rna-NM_001179809.3_CBS6412 | cds-NP_012944.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:474453-476300:- | gene-YKR019C_CBS6413 | rna-NM_001179809.3_CBS6413 | cds-NP_012944.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:475921-477768:- | gene-YKR019C_CENPK1137D | rna-NM_001179809.3_CENPK1137D | cds-NP_012944.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:472353-474200:- | gene-YKR019C_EthanolRed | rna-NM_001179809.3_EthanolRed | cds-NP_012944.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:475283-477130:- | gene-YKR019C_FaliES1 | rna-NM_001179809.3_FaliES1 | cds-NP_012944.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000077.1:76626-78473:+ | gene-YKR019C_JAY291 | rna-NM_001179809.3_JAY291 | cds-NP_012944.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:482874-484721:- | gene-YKR019C_MUCL30387 | rna-NM_001179809.3_MUCL30387 | cds-NP_012944.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:478565-480412:- | gene-YKR019C_MUCL30388 | rna-NM_001179809.3_MUCL30388 | cds-NP_012944.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:473942-475789:- | gene-YKR019C_MUCL39482 | rna-NM_001179809.3_MUCL39482 | cds-NP_012944.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:479717-481564:- | gene-YKR019C_MUCL42920 | rna-NM_001179809.3_MUCL42920 | cds-NP_012944.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:476205-478052:- | gene-YKR019C_NCIM3186 | rna-NM_001179809.3_NCIM3186 | cds-NP_012944.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:474149-475996:- | gene-YKR019C_NCYC1407 | rna-NM_001179809.3_NCYC1407 | cds-NP_012944.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:499137-500984:- | gene-YKR019C_PE2H3 | rna-NM_001179809.3_PE2H3 | cds-NP_012944.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:483860-485707:- | gene-YKR019C_PE2H4 | rna-NM_001179809.3_PE2H4 | cds-NP_012944.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:476216-478063:- | gene-YKR019C_S288C | rna-NM_001179809.3_S288C | cds-NP_012944.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000078.1:35688-37535:+ | gene-YKR019C_SA1 | rna-NM_001179809.3_SA1 | cds-NP_012944.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:474538-476385:- | gene-YKR019C_ThermosaccDry | rna-NM_001179809.3_ThermosaccDry | cds-NP_012944.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:474157-476004:- | gene-YKR019C_VR1 | rna-NM_001179809.3_VR1 | cds-NP_012944.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:472585-474432:- | gene-YKR019C_ZTW1 | rna-NM_001179809.3_ZTW1 | cds-NP_012944.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:498028-499875:- | gene-YKR019C_Sparadoxus | rna-NM_001179809.3_Sparadoxus | cds-NP_012944.3_Sparadoxus | 88.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |