Gene name: IRE1
Reference locus (S288C): YHR079C
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase/endoribonuclease IRE1; Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress
Top 10 interactors (score): KAR2 (0.999); HRD1 (0.978); HAC1 (0.972); TRL1 (0.961); PDI1 (0.927); LHS1 (0.923); ERO1 (0.923); DER1 (0.903); HRD3 (0.876); SCJ1 (0.867); CNE1 (0.857); DCR2 (0.852); INO1 (0.826); PTC2 (0.824); SEC61 (0.819); UBC7 (0.816); SPT20 (0.79); ROT2 (0.771); KRE5 (0.76); FPR2 (0.76)
Homologues (species, bitscore): ERN1 (Homo sapiens, 335.1); Ern1 (Mus musculus, 331.6); ern1 (Danio rerio, 342.8); ern2 (Xenopus tropicalis, 332.4); Ire1 (Drosophila melanogaster, 303.5); ire-1 (Caenorhabditis elegans, 325.9); IRE1A (Arabidopsis thaliana, 298.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:244657-248004:- | gene-YHR079C_AKU4011 | rna-NM_001179209.1_AKU4011 | cds-NP_011946.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:165005-168352:- | gene-YHR079C_BG1 | rna-NM_001179209.1_BG1 | cds-NP_011946.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:252485-255832:- | gene-YHR079C_Bruggeman | rna-NM_001179209.1_Bruggeman | cds-NP_011946.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:247627-250974:- | gene-YHR079C_CAT1 | rna-NM_001179209.1_CAT1 | cds-NP_011946.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:243698-247045:- | gene-YHR079C_CBS1585 | rna-NM_001179209.1_CBS1585 | cds-NP_011946.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:241558-244905:- | gene-YHR079C_CBS436 | rna-NM_001179209.1_CBS436 | cds-NP_011946.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:247044-250391:- | gene-YHR079C_CBS6412 | rna-NM_001179209.1_CBS6412 | cds-NP_011946.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:244738-248085:- | gene-YHR079C_CBS6413 | rna-NM_001179209.1_CBS6413 | cds-NP_011946.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:251414-254762:- | gene-YHR079C_CENPK1137D | rna-NM_001179209.1_CENPK1137D | cds-NP_011946.1_CENPK1137D | 99.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:304264-307611:- | gene-YHR079C_EthanolRed | rna-NM_001179209.1_EthanolRed | cds-NP_011946.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:245068-248415:- | gene-YHR079C_FaliES1 | rna-NM_001179209.1_FaliES1 | cds-NP_011946.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000394.1:27793-31140:- | gene-YHR079C_JAY291 | rna-NM_001179209.1_JAY291 | cds-NP_011946.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:252000-255347:- | gene-YHR079C_MUCL30387 | rna-NM_001179209.1_MUCL30387 | cds-NP_011946.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:251869-255216:- | gene-YHR079C_MUCL30388 | rna-NM_001179209.1_MUCL30388 | cds-NP_011946.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:244022-247369:- | gene-YHR079C_MUCL39482 | rna-NM_001179209.1_MUCL39482 | cds-NP_011946.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:250768-254115:- | gene-YHR079C_MUCL42920 | rna-NM_001179209.1_MUCL42920 | cds-NP_011946.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:258126-261473:- | gene-YHR079C_NCIM3186 | rna-NM_001179209.1_NCIM3186 | cds-NP_011946.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:246486-249833:- | gene-YHR079C_NCYC1407 | rna-NM_001179209.1_NCYC1407 | cds-NP_011946.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:246157-249504:- | gene-YHR079C_PE2H3 | rna-NM_001179209.1_PE2H3 | cds-NP_011946.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:253604-256951:- | gene-YHR079C_PE2H4 | rna-NM_001179209.1_PE2H4 | cds-NP_011946.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:258244-261591:- | gene-YHR079C_S288C | rna-NM_001179209.1_S288C | cds-NP_011946.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:97397-100744:+ | gene-YHR079C_SA1 | rna-NM_001179209.1_SA1 | cds-NP_011946.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:246159-249506:- | gene-YHR079C_ThermosaccDry | rna-NM_001179209.1_ThermosaccDry | cds-NP_011946.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:254032-257379:- | gene-YHR079C_VR1 | rna-NM_001179209.1_VR1 | cds-NP_011946.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:237710-241057:- | gene-YHR079C_ZTW1 | rna-NM_001179209.1_ZTW1 | cds-NP_011946.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:243417-246764:- | gene-YHR079C_Sparadoxus | rna-NM_001179209.1_Sparadoxus | cds-NP_011946.1_Sparadoxus | 89.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |