Gene name: IRC20
Reference locus (S288C): YLR247C
Gene biotype: protein_coding
Description: Uncharacterized ATP-dependent helicase IRC20; E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci
Top 10 interactors (score): RAD18 (0.925); UBC13 (0.902); REV3 (0.825); MMS2 (0.817); MPH1 (0.815); RAD6 (0.799); MGS1 (0.792); IRC24 (0.78); REV1 (0.758); ETP1 (0.749); MOT1 (0.701); IRC3 (0.698); YBR062C (0.696); SMT3 (0.693); MAG2 (0.684); SCC2 (0.681); UBP15 (0.678); HHF1 (0.678); RAD52 (0.67); CWC25 (0.664)
Homologues (species, bitscore): SHPRH (Homo sapiens, 139.4); Shprh (Mus musculus, 128.6); shprh (Danio rerio, 126.7); TTF2 (Xenopus tropicalis, 107.8); CG7376 (Drosophila melanogaster, 119.8); F54E12.2 (Caenorhabditis elegans, 95.1); AT2G40770 (Arabidopsis thaliana, 131.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:582897-587567:- | gene-YLR247C_AKU4011 | rna-NM_001182134.1_AKU4011 | cds-NP_013348.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:144331-149001:+ | gene-YLR247C_BG1 | rna-NM_001182134.1_BG1 | cds-NP_013348.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:617133-621803:- | gene-YLR247C_Bruggeman | rna-NM_001182134.1_Bruggeman | cds-NP_013348.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:616258-620928:- | gene-YLR247C_CAT1 | rna-NM_001182134.1_CAT1 | cds-NP_013348.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:618392-623062:- | gene-YLR247C_CBS1585 | rna-NM_001182134.1_CBS1585 | cds-NP_013348.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:602598-607268:- | gene-YLR247C_CBS436 | rna-NM_001182134.1_CBS436 | cds-NP_013348.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:581367-586037:- | gene-YLR247C_CBS6412 | rna-NM_001182134.1_CBS6412 | cds-NP_013348.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:618687-623357:- | gene-YLR247C_CBS6413 | rna-NM_001182134.1_CBS6413 | cds-NP_013348.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:613294-617964:- | gene-YLR247C_CENPK1137D | rna-NM_001182134.1_CENPK1137D | cds-NP_013348.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:577008-581678:- | gene-YLR247C_EthanolRed | rna-NM_001182134.1_EthanolRed | cds-NP_013348.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:605845-610515:- | gene-YLR247C_FaliES1 | rna-NM_001182134.1_FaliES1 | cds-NP_013348.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000136.1:48852-53522:+ | gene-YLR247C_JAY291 | rna-NM_001182134.1_JAY291 | cds-NP_013348.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:617989-622659:- | gene-YLR247C_MUCL30387 | rna-NM_001182134.1_MUCL30387 | cds-NP_013348.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:622112-626782:- | gene-YLR247C_MUCL30388 | rna-NM_001182134.1_MUCL30388 | cds-NP_013348.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:619373-624043:- | gene-YLR247C_MUCL39482 | rna-NM_001182134.1_MUCL39482 | cds-NP_013348.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:614133-618803:- | gene-YLR247C_MUCL42920 | rna-NM_001182134.1_MUCL42920 | cds-NP_013348.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:628658-633328:- | gene-YLR247C_NCIM3186 | rna-NM_001182134.1_NCIM3186 | cds-NP_013348.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:606359-611029:- | gene-YLR247C_NCYC1407 | rna-NM_001182134.1_NCYC1407 | cds-NP_013348.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:610088-614758:- | gene-YLR247C_PE2H3 | rna-NM_001182134.1_PE2H3 | cds-NP_013348.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:609832-614502:- | gene-YLR247C_PE2H4 | rna-NM_001182134.1_PE2H4 | cds-NP_013348.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:628684-633354:- | gene-YLR247C_S288C | rna-NM_001182134.1_S288C | cds-NP_013348.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:49113-53783:+ | gene-YLR247C_SA1 | rna-NM_001182134.1_SA1 | cds-NP_013348.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:607854-612524:- | gene-YLR247C_ThermosaccDry | rna-NM_001182134.1_ThermosaccDry | cds-NP_013348.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:619203-623873:- | gene-YLR247C_VR1 | rna-NM_001182134.1_VR1 | cds-NP_013348.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:132168-136838:- | gene-YLR247C_ZTW1 | rna-NM_001182134.1_ZTW1 | cds-NP_013348.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:593969-598639:- | gene-YLR247C_Sparadoxus | rna-NM_001182134.1_Sparadoxus | cds-NP_013348.1_Sparadoxus | 88.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |