Gene name: IRA2
Reference locus (S288C): YOL081W
Gene biotype: protein_coding
Description: Inhibitory regulator protein IRA2; GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
Top 10 interactors (score): RAS2 (0.996); RAS1 (0.991); CDC25 (0.966); GPB1 (0.945); CYR1 (0.945); PDE2 (0.939); BCY1 (0.938); GPB2 (0.935); TPK2 (0.922); IRA1 (0.912); GPR1 (0.903); PDE1 (0.9); TPK1 (0.9); TFS1 (0.843); GPA2 (0.824); NDC80 (0.82); TPK3 (0.813); IPL1 (0.795); MSN2 (0.777); MKT1 (0.747)
Homologues (species, bitscore): NF1 (Homo sapiens, 230.7); Nf1 (Mus musculus, 233.0); nf1a (Danio rerio, 246.9); nf1 (Xenopus tropicalis, 197.6); Nf1 (Drosophila melanogaster, 223.0); gap-2 (Caenorhabditis elegans, 63.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:154708-163947:+ | gene-YOL081W_AKU4011 | rna-NM_001183335.1_AKU4011 | cds-NP_014560.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:119520-128759:+ | gene-YOL081W_BG1 | rna-NM_001183335.1_BG1 | cds-NP_014560.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:155966-165634:+ | gene-YOL081W_Bruggeman | rna-NM_001183335.1_Bruggeman | cds-NP_014560.1_Bruggeman | 95.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:155790-165128:+ | gene-YOL081W_CAT1 | rna-NM_001183335.1_CAT1 | cds-NP_014560.1_CAT1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:149101-158340:+ | gene-YOL081W_CBS1585 | rna-NM_001183335.1_CBS1585 | cds-NP_014560.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:154286-163525:+ | gene-YOL081W_CBS436 | rna-NM_001183335.1_CBS436 | cds-NP_014560.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:149023-158268:+ | gene-YOL081W_CBS6412 | rna-NM_001183335.1_CBS6412 | cds-NP_014560.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:155964-165203:+ | gene-YOL081W_CBS6413 | rna-NM_001183335.1_CBS6413 | cds-NP_014560.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:170824-180064:+ | gene-YOL081W_CENPK1137D | rna-NM_001183335.1_CENPK1137D | cds-NP_014560.1_CENPK1137D | 99.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:152017-161262:+ | gene-YOL081W_EthanolRed | rna-NM_001183335.1_EthanolRed | cds-NP_014560.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:154344-163589:+ | gene-YOL081W_FaliES1 | rna-NM_001183335.1_FaliES1 | cds-NP_014560.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000018.1:101947-111185:- | gene-YOL081W_JAY291 | rna-NM_001183335.1_JAY291 | cds-NP_014560.1_JAY291 | 99.2 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:160165-169404:+ | gene-YOL081W_MUCL30387 | rna-NM_001183335.1_MUCL30387 | cds-NP_014560.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:163844-173083:+ | gene-YOL081W_MUCL30388 | rna-NM_001183335.1_MUCL30388 | cds-NP_014560.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:157022-166261:+ | gene-YOL081W_MUCL39482 | rna-NM_001183335.1_MUCL39482 | cds-NP_014560.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:172517-181756:+ | gene-YOL081W_MUCL42920 | rna-NM_001183335.1_MUCL42920 | cds-NP_014560.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:170959-180198:+ | gene-YOL081W_NCIM3186 | rna-NM_001183335.1_NCIM3186 | cds-NP_014560.1_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:163636-172881:+ | gene-YOL081W_NCYC1407 | rna-NM_001183335.1_NCYC1407 | cds-NP_014560.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:146639-155878:+ | gene-YOL081W_PE2H3 | rna-NM_001183335.1_PE2H3 | cds-NP_014560.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:157628-166867:+ | gene-YOL081W_PE2H4 | rna-NM_001183335.1_PE2H4 | cds-NP_014560.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:171070-180309:+ | gene-YOL081W_S288C | rna-NM_001183335.1_S288C | cds-NP_014560.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:138951-148190:+ | gene-YOL081W_SA1 | rna-NM_001183335.1_SA1 | cds-NP_014560.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:153352-162597:+ | gene-YOL081W_ThermosaccDry | rna-NM_001183335.1_ThermosaccDry | cds-NP_014560.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:154139-163378:+ | gene-YOL081W_VR1 | rna-NM_001183335.1_VR1 | cds-NP_014560.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:153020-162264:+ | gene-YOL081W_ZTW1 | rna-NM_001183335.1_ZTW1 | cds-NP_014560.1_ZTW1 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:156568-165810:+ | gene-YOL081W_Sparadoxus | rna-NM_001183335.1_Sparadoxus | cds-NP_014560.1_Sparadoxus | 89.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |