Gene name: IRA1
Reference locus (S288C): YBR140C
Gene biotype: protein_coding
Description: Inhibitory regulator protein IRA1; GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
Top 10 interactors (score): RAS2 (0.994); RAS1 (0.989); CDC25 (0.983); CYR1 (0.947); GPB2 (0.922); IRA2 (0.912); GPB1 (0.893); BCY1 (0.866); TPK2 (0.853); GPR1 (0.851); TPK1 (0.826); NDC80 (0.817); PDE2 (0.813); IPL1 (0.795); SRV2 (0.784); GPA2 (0.781); UGP1 (0.78); TPK3 (0.769); PDE1 (0.748); CDC16 (0.746)
Homologues (species, bitscore): NF1 (Homo sapiens, 227.6); Nf1 (Mus musculus, 229.6); nf1a (Danio rerio, 240.4); nf1 (Xenopus tropicalis, 200.3); Nf1 (Drosophila melanogaster, 194.5); gap-2 (Caenorhabditis elegans, 51.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:500236-509514:- | gene-YBR140C_AKU4011 | rna-NM_001178488.3_AKU4011 | cds-NP_009698.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:490808-500086:- | gene-YBR140C_BG1 | rna-NM_001178488.3_BG1 | cds-NP_009698.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:502041-511319:- | gene-YBR140C_Bruggeman | rna-NM_001178488.3_Bruggeman | cds-NP_009698.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:397381-406659:- | gene-YBR140C_CAT1 | rna-NM_001178488.3_CAT1 | cds-NP_009698.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:492016-501294:- | gene-YBR140C_CBS1585 | rna-NM_001178488.3_CBS1585 | cds-NP_009698.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:500131-509409:- | gene-YBR140C_CBS436 | rna-NM_001178488.3_CBS436 | cds-NP_009698.3_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:589882-599160:- | gene-YBR140C_CBS6412 | rna-NM_001178488.3_CBS6412 | cds-NP_009698.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:497651-506929:- | gene-YBR140C_CBS6413 | rna-NM_001178488.3_CBS6413 | cds-NP_009698.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:511120-520398:- | gene-YBR140C_CENPK1137D | rna-NM_001178488.3_CENPK1137D | cds-NP_009698.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:626258-635536:- | gene-YBR140C_EthanolRed | rna-NM_001178488.3_EthanolRed | cds-NP_009698.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:516270-525548:- | gene-YBR140C_FaliES1 | rna-NM_001178488.3_FaliES1 | cds-NP_009698.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:39731-49009:- | gene-YBR140C_JAY291 | rna-NM_001178488.3_JAY291 | cds-NP_009698.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:504915-514193:- | gene-YBR140C_MUCL30387 | rna-NM_001178488.3_MUCL30387 | cds-NP_009698.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:504205-513483:- | gene-YBR140C_MUCL30388 | rna-NM_001178488.3_MUCL30388 | cds-NP_009698.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:490403-499681:- | gene-YBR140C_MUCL39482 | rna-NM_001178488.3_MUCL39482 | cds-NP_009698.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:500307-509585:- | gene-YBR140C_MUCL42920 | rna-NM_001178488.3_MUCL42920 | cds-NP_009698.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:517147-526425:- | gene-YBR140C_NCIM3186 | rna-NM_001178488.3_NCIM3186 | cds-NP_009698.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:492942-502220:- | gene-YBR140C_NCYC1407 | rna-NM_001178488.3_NCYC1407 | cds-NP_009698.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:505577-514855:- | gene-YBR140C_PE2H3 | rna-NM_001178488.3_PE2H3 | cds-NP_009698.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:503253-512531:- | gene-YBR140C_PE2H4 | rna-NM_001178488.3_PE2H4 | cds-NP_009698.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:517350-526628:- | gene-YBR140C_S288C | rna-NM_001178488.3_S288C | cds-NP_009698.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:38534-47812:- | gene-YBR140C_SA1 | rna-NM_001178488.3_SA1 | cds-NP_009698.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:515283-524561:- | gene-YBR140C_ThermosaccDry | rna-NM_001178488.3_ThermosaccDry | cds-NP_009698.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:496783-506061:- | gene-YBR140C_VR1 | rna-NM_001178488.3_VR1 | cds-NP_009698.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:490430-499708:- | gene-YBR140C_ZTW1 | rna-NM_001178488.3_ZTW1 | cds-NP_009698.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:527669-536943:- | gene-YBR140C_Sparadoxus | rna-NM_001178488.3_Sparadoxus | cds-NP_009698.3_Sparadoxus | 89.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |