Gene name: IPL1
Reference locus (S288C): YPL209C
Gene biotype: protein_coding
Description: Spindle assembly checkpoint kinase; Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest
Top 10 interactors (score): SLI15 (0.999); NDC80 (0.999); BIR1 (0.999); CIN8 (0.998); CDC5 (0.998); BIM1 (0.996); BUB3 (0.995); MAD2 (0.994); MAD3 (0.992); GLC7 (0.992); ASE1 (0.991); BRN1 (0.99); SMC4 (0.99); STU2 (0.989); HHT1 (0.989); NUF2 (0.987); KIP2 (0.987); KAR3 (0.986); HHT2 (0.986); KIP1 (0.986)
Homologues (species, bitscore): AURKC (Homo sapiens, 285.4); Aurka (Mus musculus, 284.6); aurka (Danio rerio, 287.3); aurka (Xenopus tropicalis, 292.0); aurB (Drosophila melanogaster, 261.5); air-2 (Caenorhabditis elegans, 272.7); AUR3 (Arabidopsis thaliana, 283.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:134366-135469:- | gene-YPL209C_AKU4011 | rna-NM_001184023.1_AKU4011 | cds-NP_015115.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:340132-341235:- | gene-YPL209C_BG1 | rna-NM_001184023.1_BG1 | cds-NP_015115.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:159826-160929:- | gene-YPL209C_Bruggeman | rna-NM_001184023.1_Bruggeman | cds-NP_015115.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:156434-157537:- | gene-YPL209C_CAT1 | rna-NM_001184023.1_CAT1 | cds-NP_015115.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:138551-139654:- | gene-YPL209C_CBS1585 | rna-NM_001184023.1_CBS1585 | cds-NP_015115.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:152970-154073:- | gene-YPL209C_CBS436 | rna-NM_001184023.1_CBS436 | cds-NP_015115.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:143355-144458:- | gene-YPL209C_CBS6412 | rna-NM_001184023.1_CBS6412 | cds-NP_015115.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:134729-135832:- | gene-YPL209C_CBS6413 | rna-NM_001184023.1_CBS6413 | cds-NP_015115.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:156427-157530:- | gene-YPL209C_CENPK1137D | rna-NM_001184023.1_CENPK1137D | cds-NP_015115.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:133482-134585:- | gene-YPL209C_EthanolRed | rna-NM_001184023.1_EthanolRed | cds-NP_015115.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:140688-141791:- | gene-YPL209C_FaliES1 | rna-NM_001184023.1_FaliES1 | cds-NP_015115.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000069.1:16538-17641:+ | gene-YPL209C_JAY291 | rna-NM_001184023.1_JAY291 | cds-NP_015115.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:151538-152641:- | gene-YPL209C_MUCL30387 | rna-NM_001184023.1_MUCL30387 | cds-NP_015115.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:149729-150832:- | gene-YPL209C_MUCL30388 | rna-NM_001184023.1_MUCL30388 | cds-NP_015115.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:131681-132784:- | gene-YPL209C_MUCL39482 | rna-NM_001184023.1_MUCL39482 | cds-NP_015115.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:150560-151663:- | gene-YPL209C_MUCL42920 | rna-NM_001184023.1_MUCL42920 | cds-NP_015115.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:156473-157576:- | gene-YPL209C_NCIM3186 | rna-NM_001184023.1_NCIM3186 | cds-NP_015115.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:138130-139233:- | gene-YPL209C_NCYC1407 | rna-NM_001184023.1_NCYC1407 | cds-NP_015115.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:145833-146936:- | gene-YPL209C_PE2H3 | rna-NM_001184023.1_PE2H3 | cds-NP_015115.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:145476-146579:- | gene-YPL209C_PE2H4 | rna-NM_001184023.1_PE2H4 | cds-NP_015115.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:156490-157593:- | gene-YPL209C_S288C | rna-NM_001184023.1_S288C | cds-NP_015115.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000095.1:16589-17692:+ | gene-YPL209C_SA1 | rna-NM_001184023.1_SA1 | cds-NP_015115.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:140469-141572:- | gene-YPL209C_ThermosaccDry | rna-NM_001184023.1_ThermosaccDry | cds-NP_015115.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:154513-155616:- | gene-YPL209C_VR1 | rna-NM_001184023.1_VR1 | cds-NP_015115.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:139989-141092:- | gene-YPL209C_ZTW1 | rna-NM_001184023.1_ZTW1 | cds-NP_015115.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:141549-142652:- | gene-YPL209C_Sparadoxus | rna-NM_001184023.1_Sparadoxus | cds-NP_015115.1_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |