Gene name: IML1
Reference locus (S288C): YJR138W
Gene biotype: protein_coding
Description: GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Iml1p functions in the SEACIT complex as a GAP for the Rag family GTPase Gtr1p (EGOC subunit), resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; the Iml1p/SEACIT complex is required for non-nitrogen-starvation (NNS)-induced autophagy
Top 10 interactors (score): SEA4 (0.999); RTC1 (0.999); NPR2 (0.999); MTC5 (0.999); SEH1 (0.998); SEC13 (0.997); GTR1 (0.995); NPR3 (0.982); GTR2 (0.938); LST7 (0.775); VAC8 (0.757); MAP2 (0.675); RHB1 (0.667); TIF4631 (0.631); PRE10 (0.615); PUB1 (0.613); RRB1 (0.606); CDC55 (0.598); RPB5 (0.594); KOG1 (0.59)
Homologues (species, bitscore): DEPDC5 (Homo sapiens, 208.8); Depdc5 (Mus musculus, 196.4); depdc5 (Danio rerio, 209.1); DEPDC5 (Xenopus tropicalis, 217.6); CG12090 (Drosophila melanogaster, 200.3); T08A11.1 (Caenorhabditis elegans, 128.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:656065-660819:+ | gene-YJR138W_AKU4011 | rna-NM_001181796.2_AKU4011 | cds-NP_012672.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:12783-17537:- | gene-YJR138W_BG1 | rna-NM_001181796.2_BG1 | cds-NP_012672.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:671797-676551:+ | gene-YJR138W_Bruggeman | rna-NM_001181796.2_Bruggeman | cds-NP_012672.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:676432-681186:+ | gene-YJR138W_CAT1 | rna-NM_001181796.2_CAT1 | cds-NP_012672.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:668109-672863:+ | gene-YJR138W_CBS1585 | rna-NM_001181796.2_CBS1585 | cds-NP_012672.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:686979-691733:+ | gene-YJR138W_CBS436 | rna-NM_001181796.2_CBS436 | cds-NP_012672.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:654884-659638:+ | gene-YJR138W_CBS6412 | rna-NM_001181796.2_CBS6412 | cds-NP_012672.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:657543-662297:+ | gene-YJR138W_CBS6413 | rna-NM_001181796.2_CBS6413 | cds-NP_012672.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:666927-671681:+ | gene-YJR138W_CENPK1137D | rna-NM_001181796.2_CENPK1137D | cds-NP_012672.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:660486-665240:+ | gene-YJR138W_EthanolRed | rna-NM_001181796.2_EthanolRed | cds-NP_012672.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:671949-676703:+ | gene-YJR138W_FaliES1 | rna-NM_001181796.2_FaliES1 | cds-NP_012672.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:12456-17210:- | gene-YJR138W_JAY291 | rna-NM_001181796.2_JAY291 | cds-NP_012672.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:670824-675578:+ | gene-YJR138W_MUCL30387 | rna-NM_001181796.2_MUCL30387 | cds-NP_012672.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:668310-673064:+ | gene-YJR138W_MUCL30388 | rna-NM_001181796.2_MUCL30388 | cds-NP_012672.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:661594-666348:+ | gene-YJR138W_MUCL39482 | rna-NM_001181796.2_MUCL39482 | cds-NP_012672.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:666329-671083:+ | gene-YJR138W_MUCL42920 | rna-NM_001181796.2_MUCL42920 | cds-NP_012672.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:684546-689300:+ | gene-YJR138W_NCIM3186 | rna-NM_001181796.2_NCIM3186 | cds-NP_012672.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:659141-663895:+ | gene-YJR138W_NCYC1407 | rna-NM_001181796.2_NCYC1407 | cds-NP_012672.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:677331-682085:+ | gene-YJR138W_PE2H3 | rna-NM_001181796.2_PE2H3 | cds-NP_012672.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:671020-675774:+ | gene-YJR138W_PE2H4 | rna-NM_001181796.2_PE2H4 | cds-NP_012672.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:684567-689321:+ | gene-YJR138W_S288C | rna-NM_001181796.2_S288C | cds-NP_012672.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:12808-17562:- | gene-YJR138W_SA1 | rna-NM_001181796.2_SA1 | cds-NP_012672.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:665880-670634:+ | gene-YJR138W_ThermosaccDry | rna-NM_001181796.2_ThermosaccDry | cds-NP_012672.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:668251-673005:+ | gene-YJR138W_VR1 | rna-NM_001181796.2_VR1 | cds-NP_012672.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:645229-649983:+ | gene-YJR138W_ZTW1 | rna-NM_001181796.2_ZTW1 | cds-NP_012672.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:679536-684290:+ | gene-YJR138W_Sparadoxus | rna-NM_001181796.2_Sparadoxus | cds-NP_012672.1_Sparadoxus | 90.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |