Gene name: IMD2
Reference locus (S288C): YHR216W
Gene biotype: protein_coding
Description: Inosine-5'-monophosphate dehydrogenase 2; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication
Top 10 interactors (score): IMD3 (0.996); GUA1 (0.995); ADE12 (0.988); IMD1 (0.983); IMD4 (0.979); HPT1 (0.976); AMD1 (0.95); URA8 (0.941); ADE17 (0.938); ADE16 (0.931); HAM1 (0.92); FCY2 (0.904); ISN1 (0.901); YND1 (0.9); ADE5,7 (0.875); YAR075W (0.874); URA2 (0.869); ADE1 (0.841); URA7 (0.807); RPO21 (0.807)
Homologues (species, bitscore): IMPDH1 (Homo sapiens, 648.3); Impdh1 (Mus musculus, 645.6); impdh2 (Danio rerio, 642.5); impdh1 (Xenopus tropicalis, 635.2); ras (Drosophila melanogaster, 619.4); T22D1.3 (Caenorhabditis elegans, 501.9); AT1G16350 (Arabidopsis thaliana, 418.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:537012-538583:+ | gene-YHR216W_AKU4011 | rna-NM_001179347.3_AKU4011 | cds-NP_012088.3_AKU4011 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000108.1:357-1928:- | gene-YHR216W_BG1 | rna-NM_001179347.3_BG1 | cds-NP_012088.3_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:530232-531803:+ | gene-YHR216W_Bruggeman | rna-NM_001179347.3_Bruggeman | cds-NP_012088.3_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:549994-551814:+ | gene-YHR216W_CAT1 | rna-NM_001179347.3_CAT1 | cds-NP_012088.3_CAT1 | 85.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:541233-542804:+ | gene-YHR216W_CBS1585 | rna-NM_001179347.3_CBS1585 | cds-NP_012088.3_CBS1585 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:533648-535219:+ | gene-YHR216W_CBS436 | rna-NM_001179347.3_CBS436 | cds-NP_012088.3_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:537227-538798:+ | gene-YHR216W_CBS6412 | rna-NM_001179347.3_CBS6412 | cds-NP_012088.3_CBS6412 | 98.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:538139-539710:+ | gene-YHR216W_CBS6413 | rna-NM_001179347.3_CBS6413 | cds-NP_012088.3_CBS6413 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:548477-550078:+ | gene-YHR216W_CENPK1137D | rna-NM_001179347.3_CENPK1137D | cds-NP_012088.3_CENPK1137D | 96.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:602047-603618:+ | gene-YHR216W_EthanolRed | rna-NM_001179347.3_EthanolRed | cds-NP_012088.3_EthanolRed | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:545159-546730:+ | gene-YHR216W_FaliES1 | rna-NM_001179347.3_FaliES1 | cds-NP_012088.3_FaliES1 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000012.1:213-1784:- | gene-YHR216W_JAY291 | rna-NM_001179347.3_JAY291 | cds-NP_012088.3_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:545760-547331:+ | gene-YHR216W_MUCL30387 | rna-NM_001179347.3_MUCL30387 | cds-NP_012088.3_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:545766-547337:+ | gene-YHR216W_MUCL30388 | rna-NM_001179347.3_MUCL30388 | cds-NP_012088.3_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:538798-540369:+ | gene-YHR216W_MUCL39482 | rna-NM_001179347.3_MUCL39482 | cds-NP_012088.3_MUCL39482 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:549420-550988:+ | gene-YHR216W_MUCL42920 | rna-NM_001179347.3_MUCL42920 | cds-NP_012088.3_MUCL42920 | 96.1 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:554278-555849:+ | gene-YHR216W_NCIM3186 | rna-NM_001179347.3_NCIM3186 | cds-NP_012088.3_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:539062-540582:+ | gene-YHR216W_NCYC1407 | rna-NM_001179347.3_NCYC1407 | cds-NP_012088.3_NCYC1407 | 94.6 | 96.6 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:536417-537988:+ | gene-YHR216W_PE2H3 | rna-NM_001179347.3_PE2H3 | cds-NP_012088.3_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:543845-545416:+ | gene-YHR216W_PE2H4 | rna-NM_001179347.3_PE2H4 | cds-NP_012088.3_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:554396-555967:+ | gene-YHR216W_S288C | rna-NM_001179347.3_S288C | cds-NP_012088.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000195.1:243-1525:+ | gene-YHR216W_SA1 | rna-NM_001179347.3_SA1 | cds-NP_012088.3_SA1 | 80.7 | 81.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:545762-547333:+ | gene-YHR216W_ThermosaccDry | rna-NM_001179347.3_ThermosaccDry | cds-NP_012088.3_ThermosaccDry | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:549098-550669:+ | gene-YHR216W_VR1 | rna-NM_001179347.3_VR1 | cds-NP_012088.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:203177-203709:+ | gene-YHR216W_ZTW1 | rna-NM_001179347.3_ZTW1 | cds-NP_012088.3_ZTW1 | 33.3 | 33.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:286589-288160:+ | gene-YHR216W_Sparadoxus | rna-NM_001179347.3_Sparadoxus | cds-NP_012088.3_Sparadoxus | 93.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |