Gene name: ICL2
Reference locus (S288C): YPR006C
Gene biotype: protein_coding
Description: 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
Top 10 interactors (score): DAL7 (0.994); MLS1 (0.993); CIT3 (0.972); ACO1 (0.97); AGX1 (0.929); PDH1 (0.928); GOR1 (0.911); ICL1 (0.842); DAL3 (0.8); CIT1 (0.787); CIT2 (0.745); LYS4 (0.707); LYS12 (0.7); IDH2 (0.7); ACS1 (0.69); FUM1 (0.656); LSC1 (0.654); ACO2 (0.651); ECL1 (0.65); IDH1 (0.624)
Homologues (species, bitscore): icl-1 (Caenorhabditis elegans, 226.1); ICL (Arabidopsis thaliana, 424.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:538891-540618:- | gene-YPR006C_AKU4011 | rna-NM_001184103.1_AKU4011 | cds-NP_015331.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:356567-358294:+ | gene-YPR006C_BG1 | rna-NM_001184103.1_BG1 | cds-NP_015331.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:615906-617633:- | gene-YPR006C_Bruggeman | rna-NM_001184103.1_Bruggeman | cds-NP_015331.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:659012-660739:- | gene-YPR006C_CAT1 | rna-NM_001184103.1_CAT1 | cds-NP_015331.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:542578-544305:- | gene-YPR006C_CBS1585 | rna-NM_001184103.1_CBS1585 | cds-NP_015331.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:556992-558719:- | gene-YPR006C_CBS436 | rna-NM_001184103.1_CBS436 | cds-NP_015331.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:546327-548054:- | gene-YPR006C_CBS6412 | rna-NM_001184103.1_CBS6412 | cds-NP_015331.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:539038-540765:- | gene-YPR006C_CBS6413 | rna-NM_001184103.1_CBS6413 | cds-NP_015331.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:567244-568971:- | gene-YPR006C_CENPK1137D | rna-NM_001184103.1_CENPK1137D | cds-NP_015331.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:536825-538552:- | gene-YPR006C_EthanolRed | rna-NM_001184103.1_EthanolRed | cds-NP_015331.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:544655-546382:- | gene-YPR006C_FaliES1 | rna-NM_001184103.1_FaliES1 | cds-NP_015331.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000337.1:6487-8214:- | gene-YPR006C_JAY291 | rna-NM_001184103.1_JAY291 | cds-NP_015331.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:557117-558844:- | gene-YPR006C_MUCL30387 | rna-NM_001184103.1_MUCL30387 | cds-NP_015331.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:556218-557945:- | gene-YPR006C_MUCL30388 | rna-NM_001184103.1_MUCL30388 | cds-NP_015331.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:535818-537545:- | gene-YPR006C_MUCL39482 | rna-NM_001184103.1_MUCL39482 | cds-NP_015331.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:596000-597727:- | gene-YPR006C_MUCL42920 | rna-NM_001184103.1_MUCL42920 | cds-NP_015331.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:567252-568979:- | gene-YPR006C_NCIM3186 | rna-NM_001184103.1_NCIM3186 | cds-NP_015331.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:543517-545244:- | gene-YPR006C_NCYC1407 | rna-NM_001184103.1_NCYC1407 | cds-NP_015331.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:550447-552174:- | gene-YPR006C_PE2H3 | rna-NM_001184103.1_PE2H3 | cds-NP_015331.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:550062-551789:- | gene-YPR006C_PE2H4 | rna-NM_001184103.1_PE2H4 | cds-NP_015331.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:567269-568996:- | gene-YPR006C_S288C | rna-NM_001184103.1_S288C | cds-NP_015331.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:131294-133021:+ | gene-YPR006C_SA1 | rna-NM_001184103.1_SA1 | cds-NP_015331.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:544454-546181:- | gene-YPR006C_ThermosaccDry | rna-NM_001184103.1_ThermosaccDry | cds-NP_015331.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:560701-562428:- | gene-YPR006C_VR1 | rna-NM_001184103.1_VR1 | cds-NP_015331.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:543759-545486:- | gene-YPR006C_ZTW1 | rna-NM_001184103.1_ZTW1 | cds-NP_015331.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:543358-545085:- | gene-YPR006C_Sparadoxus | rna-NM_001184103.1_Sparadoxus | cds-NP_015331.1_Sparadoxus | 89.6 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |