Gene name: HYP2
Reference locus (S288C): YEL034W
Gene biotype: protein_coding
Description: Eukaryotic translation initiation factor 5A-1; Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches, including Bni1p, and this leads to a requirement for mating projection formation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant
Top 10 interactors (score): LIA1 (0.999); DYS1 (0.999); RPL5 (0.997); RPL10 (0.994); RPS2 (0.993); ASC1 (0.99); RPS13 (0.99); RPL28 (0.989); RPS20 (0.986); RPS15 (0.986); RPP0 (0.986); RPL15A (0.986); RPL38 (0.985); RPL39 (0.985); RPS3 (0.985); RPL9A (0.983); RPS0A (0.979); RPL29 (0.977); TEF4 (0.976); RPL13A (0.973)
Homologues (species, bitscore): EIF5A (Homo sapiens, 217.6); Eif5a (Mus musculus, 217.6); eif5a (Danio rerio, 221.1); eif5a (Xenopus tropicalis, 205.7); eIF-5A (Drosophila melanogaster, 211.8); iff-2 (Caenorhabditis elegans, 195.3); ELF5A-1 (Arabidopsis thaliana, 198.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:79740-80213:+ | gene-YEL034W_AKU4011 | rna-NM_001178849.3_AKU4011 | cds-NP_010880.3_AKU4011 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000075.1:362-835:- | gene-YEL034W_BG1 | rna-NM_001178849.3_BG1 | cds-NP_010880.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:83864-84337:+ | gene-YEL034W_Bruggeman | rna-NM_001178849.3_Bruggeman | cds-NP_010880.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:81647-82120:+ | gene-YEL034W_CAT1 | rna-NM_001178849.3_CAT1 | cds-NP_010880.3_CAT1 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:79682-80155:+ | gene-YEL034W_CBS1585 | rna-NM_001178849.3_CBS1585 | cds-NP_010880.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:81286-81759:+ | gene-YEL034W_CBS436 | rna-NM_001178849.3_CBS436 | cds-NP_010880.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:79935-80408:+ | gene-YEL034W_CBS6412 | rna-NM_001178849.3_CBS6412 | cds-NP_010880.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:84574-85047:+ | gene-YEL034W_CBS6413 | rna-NM_001178849.3_CBS6413 | cds-NP_010880.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:83502-83975:+ | gene-YEL034W_CENPK1137D | rna-NM_001178849.3_CENPK1137D | cds-NP_010880.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:79488-79961:+ | gene-YEL034W_EthanolRed | rna-NM_001178849.3_EthanolRed | cds-NP_010880.3_EthanolRed | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:79754-80227:+ | gene-YEL034W_FaliES1 | rna-NM_001178849.3_FaliES1 | cds-NP_010880.3_FaliES1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000193.1:342-622:- | gene-YEL034W_JAY291 | rna-NM_001178849.3_JAY291 | cds-NP_010880.3_JAY291 | 59.0 | 59.2 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:83934-84407:+ | gene-YEL034W_MUCL30387 | rna-NM_001178849.3_MUCL30387 | cds-NP_010880.3_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:79723-80196:+ | gene-YEL034W_MUCL30388 | rna-NM_001178849.3_MUCL30388 | cds-NP_010880.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:79051-79524:+ | gene-YEL034W_MUCL39482 | rna-NM_001178849.3_MUCL39482 | cds-NP_010880.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:83684-84157:+ | gene-YEL034W_MUCL42920 | rna-NM_001178849.3_MUCL42920 | cds-NP_010880.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:85675-86148:+ | gene-YEL034W_NCIM3186 | rna-NM_001178849.3_NCIM3186 | cds-NP_010880.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:84144-84617:+ | gene-YEL034W_NCYC1407 | rna-NM_001178849.3_NCYC1407 | cds-NP_010880.3_NCYC1407 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:88156-88629:+ | gene-YEL034W_PE2H3 | rna-NM_001178849.3_PE2H3 | cds-NP_010880.3_PE2H3 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:84071-84544:+ | gene-YEL034W_PE2H4 | rna-NM_001178849.3_PE2H4 | cds-NP_010880.3_PE2H4 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:85676-86149:+ | gene-YEL034W_S288C | rna-NM_001178849.3_S288C | cds-NP_010880.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:436-909:- | gene-YEL034W_SA1 | rna-NM_001178849.3_SA1 | cds-NP_010880.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:80153-80626:+ | gene-YEL034W_ThermosaccDry | rna-NM_001178849.3_ThermosaccDry | cds-NP_010880.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:79359-79832:+ | gene-YEL034W_VR1 | rna-NM_001178849.3_VR1 | cds-NP_010880.3_VR1 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:79088-79561:+ | gene-YEL034W_ZTW1 | rna-NM_001178849.3_ZTW1 | cds-NP_010880.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:81715-82188:+ | gene-YEL034W_Sparadoxus | rna-NM_001178849.3_Sparadoxus | cds-NP_010880.3_Sparadoxus | 97.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |