Gene name: HXK2
Reference locus (S288C): YGL253W
Gene biotype: protein_coding
Description: Hexokinase-2; Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1
Top 10 interactors (score): HXK1 (0.999); GLK1 (0.999); MIG1 (0.998); PGI1 (0.991); SUC2 (0.983); FBP1 (0.983); SNF1 (0.98); YLR446W (0.976); PFK1 (0.969); ZWF1 (0.964); FBA1 (0.96); NTH1 (0.955); RGT2 (0.948); PMI40 (0.944); GNA1 (0.939); TKL1 (0.938); NTH2 (0.938); SNF3 (0.93); GAL10 (0.915); TPS1 (0.915)
Homologues (species, bitscore): HKDC1 (Homo sapiens, 270.0); Hk1 (Mus musculus, 266.9); hk1 (Danio rerio, 256.9); Hkdc1 (Xenopus tropicalis, 274.6); Hex-t2 (Drosophila melanogaster, 266.5); F14B4.2 (Caenorhabditis elegans, 256.1); HXK1 (Arabidopsis thaliana, 264.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:25461-26921:+ | gene-YGL253W_AKU4011 | rna-NM_001181119.1_AKU4011 | cds-NP_011261.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000175.1:17501-18961:+ | gene-YGL253W_BG1 | rna-NM_001181119.1_BG1 | cds-NP_011261.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:25817-27277:+ | gene-YGL253W_Bruggeman | rna-NM_001181119.1_Bruggeman | cds-NP_011261.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:23889-25349:+ | gene-YGL253W_CAT1 | rna-NM_001181119.1_CAT1 | cds-NP_011261.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:29749-31209:+ | gene-YGL253W_CBS1585 | rna-NM_001181119.1_CBS1585 | cds-NP_011261.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:24478-25938:+ | gene-YGL253W_CBS436 | rna-NM_001181119.1_CBS436 | cds-NP_011261.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:17317-18777:+ | gene-YGL253W_CBS6412 | rna-NM_001181119.1_CBS6412 | cds-NP_011261.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:23605-25065:+ | gene-YGL253W_CBS6413 | rna-NM_001181119.1_CBS6413 | cds-NP_011261.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:23600-25060:+ | gene-YGL253W_CENPK1137D | rna-NM_001181119.1_CENPK1137D | cds-NP_011261.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:16738-18198:+ | gene-YGL253W_EthanolRed | rna-NM_001181119.1_EthanolRed | cds-NP_011261.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:17099-18559:+ | gene-YGL253W_FaliES1 | rna-NM_001181119.1_FaliES1 | cds-NP_011261.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000079.1:48521-49981:- | gene-YGL253W_JAY291 | rna-NM_001181119.1_JAY291 | cds-NP_011261.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:25753-27213:+ | gene-YGL253W_MUCL30387 | rna-NM_001181119.1_MUCL30387 | cds-NP_011261.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:27907-29367:+ | gene-YGL253W_MUCL30388 | rna-NM_001181119.1_MUCL30388 | cds-NP_011261.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:26346-27806:+ | gene-YGL253W_MUCL39482 | rna-NM_001181119.1_MUCL39482 | cds-NP_011261.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:29240-30700:+ | gene-YGL253W_MUCL42920 | rna-NM_001181119.1_MUCL42920 | cds-NP_011261.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:23935-25395:+ | gene-YGL253W_NCIM3186 | rna-NM_001181119.1_NCIM3186 | cds-NP_011261.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:18110-19570:+ | gene-YGL253W_NCYC1407 | rna-NM_001181119.1_NCYC1407 | cds-NP_011261.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:19966-21426:+ | gene-YGL253W_PE2H3 | rna-NM_001181119.1_PE2H3 | cds-NP_011261.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:19514-20974:+ | gene-YGL253W_PE2H4 | rna-NM_001181119.1_PE2H4 | cds-NP_011261.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:23935-25395:+ | gene-YGL253W_S288C | rna-NM_001181119.1_S288C | cds-NP_011261.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:349937-351397:- | gene-YGL253W_SA1 | rna-NM_001181119.1_SA1 | cds-NP_011261.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:17414-18874:+ | gene-YGL253W_ThermosaccDry | rna-NM_001181119.1_ThermosaccDry | cds-NP_011261.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:24404-25864:+ | gene-YGL253W_VR1 | rna-NM_001181119.1_VR1 | cds-NP_011261.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:16488-17948:+ | gene-YGL253W_ZTW1 | rna-NM_001181119.1_ZTW1 | cds-NP_011261.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:25145-26605:+ | gene-YGL253W_Sparadoxus | rna-NM_001181119.1_Sparadoxus | cds-NP_011261.1_Sparadoxus | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |