Gene name: HUL5
Reference locus (S288C): YGL141W
Gene biotype: protein_coding
Description: Probable E3 ubiquitin-protein ligase HUL5; Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock
Top 10 interactors (score): UBP6 (0.99); UBR1 (0.972); UFD2 (0.96); RPN11 (0.957); RPN10 (0.919); UBR2 (0.909); RKR1 (0.895); RPN13 (0.892); SSM4 (0.872); SAN1 (0.859); UFD4 (0.855); DSK2 (0.852); UBC4 (0.839); UBP2 (0.834); ECM29 (0.834); RPN6 (0.833); UBC1 (0.833); RAD23 (0.796); RPN12 (0.79); RPT5 (0.786)
Homologues (species, bitscore): UBE3C (Homo sapiens, 276.2); Ube3c (Mus musculus, 271.9); ube3c (Danio rerio, 274.2); ube3c (Xenopus tropicalis, 274.6); CG3356 (Drosophila melanogaster, 264.2); oxi-1 (Caenorhabditis elegans, 235.0); UPL7 (Arabidopsis thaliana, 286.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:240940-243672:+ | gene-YGL141W_AKU4011 | rna-NM_001181006.1_AKU4011 | cds-NP_011374.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:161279-164011:- | gene-YGL141W_BG1 | rna-NM_001181006.1_BG1 | cds-NP_011374.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:243365-246097:+ | gene-YGL141W_Bruggeman | rna-NM_001181006.1_Bruggeman | cds-NP_011374.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:238957-241689:+ | gene-YGL141W_CAT1 | rna-NM_001181006.1_CAT1 | cds-NP_011374.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:244322-247054:+ | gene-YGL141W_CBS1585 | rna-NM_001181006.1_CBS1585 | cds-NP_011374.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:238914-241646:+ | gene-YGL141W_CBS436 | rna-NM_001181006.1_CBS436 | cds-NP_011374.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:230532-233264:+ | gene-YGL141W_CBS6412 | rna-NM_001181006.1_CBS6412 | cds-NP_011374.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:238878-241610:+ | gene-YGL141W_CBS6413 | rna-NM_001181006.1_CBS6413 | cds-NP_011374.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:238615-241347:+ | gene-YGL141W_CENPK1137D | rna-NM_001181006.1_CENPK1137D | cds-NP_011374.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:231081-233819:+ | gene-YGL141W_EthanolRed | rna-NM_001181006.1_EthanolRed | cds-NP_011374.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:232327-235065:+ | gene-YGL141W_FaliES1 | rna-NM_001181006.1_FaliES1 | cds-NP_011374.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000090.1:82156-84888:+ | gene-YGL141W_JAY291 | rna-NM_001181006.1_JAY291 | cds-NP_011374.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:240335-243067:+ | gene-YGL141W_MUCL30387 | rna-NM_001181006.1_MUCL30387 | cds-NP_011374.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:243450-246182:+ | gene-YGL141W_MUCL30388 | rna-NM_001181006.1_MUCL30388 | cds-NP_011374.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:241103-243835:+ | gene-YGL141W_MUCL39482 | rna-NM_001181006.1_MUCL39482 | cds-NP_011374.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:244324-247056:+ | gene-YGL141W_MUCL42920 | rna-NM_001181006.1_MUCL42920 | cds-NP_011374.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:238353-241085:+ | gene-YGL141W_NCIM3186 | rna-NM_001181006.1_NCIM3186 | cds-NP_011374.1_NCIM3186 | 94.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:232593-235325:+ | gene-YGL141W_NCYC1407 | rna-NM_001181006.1_NCYC1407 | cds-NP_011374.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:234459-237191:+ | gene-YGL141W_PE2H3 | rna-NM_001181006.1_PE2H3 | cds-NP_011374.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:239454-242186:+ | gene-YGL141W_PE2H4 | rna-NM_001181006.1_PE2H4 | cds-NP_011374.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:238353-241085:+ | gene-YGL141W_S288C | rna-NM_001181006.1_S288C | cds-NP_011374.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000081.1:13664-16396:- | gene-YGL141W_SA1 | rna-NM_001181006.1_SA1 | cds-NP_011374.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:232556-235294:+ | gene-YGL141W_ThermosaccDry | rna-NM_001181006.1_ThermosaccDry | cds-NP_011374.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:239373-242105:+ | gene-YGL141W_VR1 | rna-NM_001181006.1_VR1 | cds-NP_011374.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:230663-233395:+ | gene-YGL141W_ZTW1 | rna-NM_001181006.1_ZTW1 | cds-NP_011374.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:236726-239458:+ | gene-YGL141W_Sparadoxus | rna-NM_001181006.1_Sparadoxus | cds-NP_011374.1_Sparadoxus | 89.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |