Gene name: HST4
Reference locus (S288C): YDR191W
Gene biotype: protein_coding
Description: NAD-dependent histone deacetylase HST4; NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3
Top 10 interactors (score): PNC1 (0.978); RTT109 (0.962); HST3 (0.941); QNS1 (0.918); PNP1 (0.912); RPD3 (0.91); UTR1 (0.909); ASF1 (0.907); NPY1 (0.903); AMD2 (0.902); URH1 (0.9); HHT1 (0.87); HHT2 (0.828); RTT106 (0.814); HDA1 (0.801); NMA1 (0.766); NMA2 (0.766); HHF1 (0.748); HOS3 (0.739); RAD9 (0.731)
Homologues (species, bitscore): SIRT1 (Homo sapiens, 84.0); Sirt1 (Mus musculus, 83.6); sirt1 (Danio rerio, 87.8); sirt1 (Xenopus tropicalis, 82.4); Sir2 (Drosophila melanogaster, 89.0); sir-2.1 (Caenorhabditis elegans, 75.9); SRT1 (Arabidopsis thaliana, 60.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:810870-811982:+ | gene-YDR191W_AKU4011 | rna-NM_001180499.3_AKU4011 | cds-NP_010477.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:313836-314948:- | gene-YDR191W_BG1 | rna-NM_001180499.3_BG1 | cds-NP_010477.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:843283-844395:+ | gene-YDR191W_Bruggeman | rna-NM_001180499.3_Bruggeman | cds-NP_010477.3_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:830551-831663:+ | gene-YDR191W_CAT1 | rna-NM_001180499.3_CAT1 | cds-NP_010477.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:801232-802344:+ | gene-YDR191W_CBS1585 | rna-NM_001180499.3_CBS1585 | cds-NP_010477.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:830236-831348:+ | gene-YDR191W_CBS436 | rna-NM_001180499.3_CBS436 | cds-NP_010477.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:798039-799151:+ | gene-YDR191W_CBS6412 | rna-NM_001180499.3_CBS6412 | cds-NP_010477.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:828581-829693:+ | gene-YDR191W_CBS6413 | rna-NM_001180499.3_CBS6413 | cds-NP_010477.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:841169-842281:+ | gene-YDR191W_CENPK1137D | rna-NM_001180499.3_CENPK1137D | cds-NP_010477.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:811630-812742:+ | gene-YDR191W_EthanolRed | rna-NM_001180499.3_EthanolRed | cds-NP_010477.3_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:819842-820954:+ | gene-YDR191W_FaliES1 | rna-NM_001180499.3_FaliES1 | cds-NP_010477.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000068.1:28406-29518:- | gene-YDR191W_JAY291 | rna-NM_001180499.3_JAY291 | cds-NP_010477.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:828936-830048:+ | gene-YDR191W_MUCL30387 | rna-NM_001180499.3_MUCL30387 | cds-NP_010477.3_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:817185-818297:+ | gene-YDR191W_MUCL30388 | rna-NM_001180499.3_MUCL30388 | cds-NP_010477.3_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:802679-803791:+ | gene-YDR191W_MUCL39482 | rna-NM_001180499.3_MUCL39482 | cds-NP_010477.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:741379-742491:+ | gene-YDR191W_MUCL42920 | rna-NM_001180499.3_MUCL42920 | cds-NP_010477.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:842260-843372:+ | gene-YDR191W_NCIM3186 | rna-NM_001180499.3_NCIM3186 | cds-NP_010477.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:805813-806925:+ | gene-YDR191W_NCYC1407 | rna-NM_001180499.3_NCYC1407 | cds-NP_010477.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:822555-823667:+ | gene-YDR191W_PE2H3 | rna-NM_001180499.3_PE2H3 | cds-NP_010477.3_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:821860-822972:+ | gene-YDR191W_PE2H4 | rna-NM_001180499.3_PE2H4 | cds-NP_010477.3_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:842337-843449:+ | gene-YDR191W_S288C | rna-NM_001180499.3_S288C | cds-NP_010477.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:188039-189151:+ | gene-YDR191W_SA1 | rna-NM_001180499.3_SA1 | cds-NP_010477.3_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:817997-819109:+ | gene-YDR191W_ThermosaccDry | rna-NM_001180499.3_ThermosaccDry | cds-NP_010477.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:833214-834326:+ | gene-YDR191W_VR1 | rna-NM_001180499.3_VR1 | cds-NP_010477.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:80710-81822:+ | gene-YDR191W_ZTW1 | rna-NM_001180499.3_ZTW1 | cds-NP_010477.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:822941-824053:+ | gene-YDR191W_Sparadoxus | rna-NM_001180499.3_Sparadoxus | cds-NP_010477.3_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |