Gene name: HST2
Reference locus (S288C): YPL015C
Gene biotype: protein_coding
Description: Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export; Belongs to the sirtuin family. Class I subfamily
Top 10 interactors (score): SOD2 (0.969); ACS1 (0.96); ACS2 (0.96); PNC1 (0.956); QNS1 (0.924); PNP1 (0.918); NPY1 (0.912); UTR1 (0.909); URH1 (0.907); AMD2 (0.902); HDA1 (0.89); HOS2 (0.883); RPD3 (0.879); HOS3 (0.817); NMA1 (0.814); NMA2 (0.805); GCN5 (0.789); HOS1 (0.765); YOR050C (0.748); HHF2 (0.707)
Homologues (species, bitscore): SIRT3 (Homo sapiens, 231.5); Sirt2 (Mus musculus, 222.6); sirt2 (Danio rerio, 248.8); sirt2 (Xenopus tropicalis, 228.8); Sirt2 (Drosophila melanogaster, 221.5); sir-2.1 (Caenorhabditis elegans, 171.8); SRT1 (Arabidopsis thaliana, 75.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:497285-498355:- | gene-YPL015C_AKU4011 | rna-NM_001183829.1_AKU4011 | cds-NP_015310.1_AKU4011 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:398952-400022:+ | gene-YPL015C_BG1 | rna-NM_001183829.1_BG1 | cds-NP_015310.1_BG1 | 99.1 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:574236-575309:- | gene-YPL015C_Bruggeman | rna-NM_001183829.1_Bruggeman | cds-NP_015310.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:616676-617746:- | gene-YPL015C_CAT1 | rna-NM_001183829.1_CAT1 | cds-NP_015310.1_CAT1 | 98.8 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:501447-502517:- | gene-YPL015C_CBS1585 | rna-NM_001183829.1_CBS1585 | cds-NP_015310.1_CBS1585 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:515501-516574:- | gene-YPL015C_CBS436 | rna-NM_001183829.1_CBS436 | cds-NP_015310.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:505199-506269:- | gene-YPL015C_CBS6412 | rna-NM_001183829.1_CBS6412 | cds-NP_015310.1_CBS6412 | 98.6 | 99.7 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:497922-498992:- | gene-YPL015C_CBS6413 | rna-NM_001183829.1_CBS6413 | cds-NP_015310.1_CBS6413 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:525817-526890:- | gene-YPL015C_CENPK1137D | rna-NM_001183829.1_CENPK1137D | cds-NP_015310.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:495706-496776:- | gene-YPL015C_EthanolRed | rna-NM_001183829.1_EthanolRed | cds-NP_015310.1_EthanolRed | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:503536-504606:- | gene-YPL015C_FaliES1 | rna-NM_001183829.1_FaliES1 | cds-NP_015310.1_FaliES1 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000283.1:112095-113168:- | gene-YPL015C_JAY291 | rna-NM_001183829.1_JAY291 | cds-NP_015310.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:515185-516258:- | gene-YPL015C_MUCL30387 | rna-NM_001183829.1_MUCL30387 | cds-NP_015310.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:514293-515366:- | gene-YPL015C_MUCL30388 | rna-NM_001183829.1_MUCL30388 | cds-NP_015310.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:494687-495757:- | gene-YPL015C_MUCL39482 | rna-NM_001183829.1_MUCL39482 | cds-NP_015310.1_MUCL39482 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:553777-554850:- | gene-YPL015C_MUCL42920 | rna-NM_001183829.1_MUCL42920 | cds-NP_015310.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:525793-526866:- | gene-YPL015C_NCIM3186 | rna-NM_001183829.1_NCIM3186 | cds-NP_015310.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:501961-503031:- | gene-YPL015C_NCYC1407 | rna-NM_001183829.1_NCYC1407 | cds-NP_015310.1_NCYC1407 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:508622-509695:- | gene-YPL015C_PE2H3 | rna-NM_001183829.1_PE2H3 | cds-NP_015310.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:508237-509310:- | gene-YPL015C_PE2H4 | rna-NM_001183829.1_PE2H4 | cds-NP_015310.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:525810-526883:- | gene-YPL015C_S288C | rna-NM_001183829.1_S288C | cds-NP_015310.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000076.1:22524-23594:- | gene-YPL015C_SA1 | rna-NM_001183829.1_SA1 | cds-NP_015310.1_SA1 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:503335-504405:- | gene-YPL015C_ThermosaccDry | rna-NM_001183829.1_ThermosaccDry | cds-NP_015310.1_ThermosaccDry | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:518724-519797:- | gene-YPL015C_VR1 | rna-NM_001183829.1_VR1 | cds-NP_015310.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:502621-503691:- | gene-YPL015C_ZTW1 | rna-NM_001183829.1_ZTW1 | cds-NP_015310.1_ZTW1 | 98.6 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:502510-503592:- | gene-YPL015C_Sparadoxus | rna-NM_001183829.1_Sparadoxus | cds-NP_015310.1_Sparadoxus | 88.2 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |