Gene name: HST1
Reference locus (S288C): YOL068C
Gene biotype: protein_coding
Description: NAD-dependent protein deacetylase HST1; NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication
Top 10 interactors (score): SUM1 (0.996); SNT1 (0.994); RFM1 (0.992); HOS2 (0.988); HOS4 (0.977); SET3 (0.976); PNC1 (0.975); SIF2 (0.974); CPR1 (0.936); QNS1 (0.918); NMA2 (0.913); PNP1 (0.912); UTR1 (0.909); SIR2 (0.908); HDA1 (0.902); NPY1 (0.902); AMD2 (0.902); URH1 (0.9); YKU70 (0.898); RPD3 (0.891)
Homologues (species, bitscore): SIRT1 (Homo sapiens, 227.6); Sirt1 (Mus musculus, 227.6); sirt1 (Danio rerio, 244.2); sirt1 (Xenopus tropicalis, 231.9); Sir2 (Drosophila melanogaster, 248.1); sir-2.1 (Caenorhabditis elegans, 208.4); SRT2 (Arabidopsis thaliana, 73.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:184022-185533:- | gene-YOL068C_AKU4011 | rna-NM_001183323.1_AKU4011 | cds-NP_014573.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:1-1486:- | gene-YOL068C_BG1 | rna-NM_001183323.1_BG1 | cds-NP_014573.1_BG1 | 97.8 | 98.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:185692-187203:- | gene-YOL068C_Bruggeman | rna-NM_001183323.1_Bruggeman | cds-NP_014573.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:185204-186715:- | gene-YOL068C_CAT1 | rna-NM_001183323.1_CAT1 | cds-NP_014573.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:178413-179924:- | gene-YOL068C_CBS1585 | rna-NM_001183323.1_CBS1585 | cds-NP_014573.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:183572-185083:- | gene-YOL068C_CBS436 | rna-NM_001183323.1_CBS436 | cds-NP_014573.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:178342-179853:- | gene-YOL068C_CBS6412 | rna-NM_001183323.1_CBS6412 | cds-NP_014573.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:185278-186789:- | gene-YOL068C_CBS6413 | rna-NM_001183323.1_CBS6413 | cds-NP_014573.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:200118-201629:- | gene-YOL068C_CENPK1137D | rna-NM_001183323.1_CENPK1137D | cds-NP_014573.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:181122-182633:- | gene-YOL068C_EthanolRed | rna-NM_001183323.1_EthanolRed | cds-NP_014573.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:183665-185176:- | gene-YOL068C_FaliES1 | rna-NM_001183323.1_FaliES1 | cds-NP_014573.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000018.1:80381-81892:+ | gene-YOL068C_JAY291 | rna-NM_001183323.1_JAY291 | cds-NP_014573.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:189456-190967:- | gene-YOL068C_MUCL30387 | rna-NM_001183323.1_MUCL30387 | cds-NP_014573.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:193141-194652:- | gene-YOL068C_MUCL30388 | rna-NM_001183323.1_MUCL30388 | cds-NP_014573.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:186333-187844:- | gene-YOL068C_MUCL39482 | rna-NM_001183323.1_MUCL39482 | cds-NP_014573.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:201814-203325:- | gene-YOL068C_MUCL42920 | rna-NM_001183323.1_MUCL42920 | cds-NP_014573.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:200257-201768:- | gene-YOL068C_NCIM3186 | rna-NM_001183323.1_NCIM3186 | cds-NP_014573.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:192950-194461:- | gene-YOL068C_NCYC1407 | rna-NM_001183323.1_NCYC1407 | cds-NP_014573.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:175956-177467:- | gene-YOL068C_PE2H3 | rna-NM_001183323.1_PE2H3 | cds-NP_014573.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:186946-188457:- | gene-YOL068C_PE2H4 | rna-NM_001183323.1_PE2H4 | cds-NP_014573.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:200368-201879:- | gene-YOL068C_S288C | rna-NM_001183323.1_S288C | cds-NP_014573.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:168258-169769:- | gene-YOL068C_SA1 | rna-NM_001183323.1_SA1 | cds-NP_014573.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:182673-184184:- | gene-YOL068C_ThermosaccDry | rna-NM_001183323.1_ThermosaccDry | cds-NP_014573.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:183436-184947:- | gene-YOL068C_VR1 | rna-NM_001183323.1_VR1 | cds-NP_014573.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:182317-183828:- | gene-YOL068C_ZTW1 | rna-NM_001183323.1_ZTW1 | cds-NP_014573.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:185846-187360:- | gene-YOL068C_Sparadoxus | rna-NM_001183323.1_Sparadoxus | cds-NP_014573.1_Sparadoxus | 91.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |