Gene name: HSP104
Reference locus (S288C): YLL026W
Gene biotype: protein_coding
Description: Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation; Belongs to the ClpA/ClpB family
Top 10 interactors (score): SSA1 (0.999); HSP82 (0.999); SUP35 (0.999); HSP78 (0.999); YDJ1 (0.999); SIS1 (0.999); STI1 (0.999); HSP42 (0.999); SSA4 (0.998); SGT2 (0.998); HSP26 (0.997); CPR6 (0.995); SSE2 (0.995); TPS1 (0.994); HSC82 (0.993); FES1 (0.992); AHA1 (0.99); NTH1 (0.988); SSA2 (0.984); BTN2 (0.98)
Homologues (species, bitscore): CLPB (Homo sapiens, 191.8); Clpb (Mus musculus, 194.5); CLPB (Danio rerio, 136.3); clpb (Xenopus tropicalis, 153.7); HSP101 (Arabidopsis thaliana, 735.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:75785-78511:+ | gene-YLL026W_AKU4011 | rna-NM_001181846.1_AKU4011 | cds-NP_013074.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:39732-42458:+ | gene-YLL026W_BG1 | rna-NM_001181846.1_BG1 | cds-NP_013074.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:86039-88765:+ | gene-YLL026W_Bruggeman | rna-NM_001181846.1_Bruggeman | cds-NP_013074.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:86656-89382:+ | gene-YLL026W_CAT1 | rna-NM_001181846.1_CAT1 | cds-NP_013074.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:83483-86209:+ | gene-YLL026W_CBS1585 | rna-NM_001181846.1_CBS1585 | cds-NP_013074.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:73684-76410:+ | gene-YLL026W_CBS436 | rna-NM_001181846.1_CBS436 | cds-NP_013074.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:83400-86126:+ | gene-YLL026W_CBS6412 | rna-NM_001181846.1_CBS6412 | cds-NP_013074.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:83492-86218:+ | gene-YLL026W_CBS6413 | rna-NM_001181846.1_CBS6413 | cds-NP_013074.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:73628-76354:+ | gene-YLL026W_CENPK1137D | rna-NM_001181846.1_CENPK1137D | cds-NP_013074.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:76179-78905:+ | gene-YLL026W_EthanolRed | rna-NM_001181846.1_EthanolRed | cds-NP_013074.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:75493-78219:+ | gene-YLL026W_FaliES1 | rna-NM_001181846.1_FaliES1 | cds-NP_013074.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000118.1:786-3512:- | gene-YLL026W_JAY291 | rna-NM_001181846.1_JAY291 | cds-NP_013074.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:83453-86179:+ | gene-YLL026W_MUCL30387 | rna-NM_001181846.1_MUCL30387 | cds-NP_013074.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:88179-90905:+ | gene-YLL026W_MUCL30388 | rna-NM_001181846.1_MUCL30388 | cds-NP_013074.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:83692-86418:+ | gene-YLL026W_MUCL39482 | rna-NM_001181846.1_MUCL39482 | cds-NP_013074.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:83789-86515:+ | gene-YLL026W_MUCL42920 | rna-NM_001181846.1_MUCL42920 | cds-NP_013074.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:88597-91323:+ | gene-YLL026W_NCIM3186 | rna-NM_001181846.1_NCIM3186 | cds-NP_013074.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:75575-78301:+ | gene-YLL026W_NCYC1407 | rna-NM_001181846.1_NCYC1407 | cds-NP_013074.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:82243-84969:+ | gene-YLL026W_PE2H3 | rna-NM_001181846.1_PE2H3 | cds-NP_013074.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:82051-84777:+ | gene-YLL026W_PE2H4 | rna-NM_001181846.1_PE2H4 | cds-NP_013074.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:88623-91349:+ | gene-YLL026W_S288C | rna-NM_001181846.1_S288C | cds-NP_013074.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:82212-84938:+ | gene-YLL026W_SA1 | rna-NM_001181846.1_SA1 | cds-NP_013074.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:75999-78725:+ | gene-YLL026W_ThermosaccDry | rna-NM_001181846.1_ThermosaccDry | cds-NP_013074.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:90061-92787:+ | gene-YLL026W_VR1 | rna-NM_001181846.1_VR1 | cds-NP_013074.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:75569-78295:+ | gene-YLL026W_ZTW1 | rna-NM_001181846.1_ZTW1 | cds-NP_013074.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:84132-86855:+ | gene-YLL026W_Sparadoxus | rna-NM_001181846.1_Sparadoxus | cds-NP_013074.1_Sparadoxus | 91.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |