Gene name: HSC82
Reference locus (S288C): YMR186W
Gene biotype: protein_coding
Description: ATP-dependent molecular chaperone HSC82; Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication
Top 10 interactors (score): SSA2 (0.999); STI1 (0.999); AHA1 (0.999); SGT1 (0.999); SSE1 (0.999); CDC37 (0.999); SSA1 (0.999); CPR6 (0.999); SBA1 (0.999); PPT1 (0.999); HSP82 (0.999); CPR7 (0.998); HSF1 (0.998); HSP60 (0.998); YDJ1 (0.998); SIS1 (0.996); KAR2 (0.993); CNS1 (0.993); HSP104 (0.993); TAH1 (0.991)
Homologues (species, bitscore): HSP90AB1 (Homo sapiens, 890.2); Hsp90ab1 (Mus musculus, 891.0); hsp90ab1 (Danio rerio, 881.3); hsp90ab1 (Xenopus tropicalis, 893.6); Hsp83 (Drosophila melanogaster, 877.1); daf-21 (Caenorhabditis elegans, 863.2); HSP90.1 (Arabidopsis thaliana, 919.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:672287-674404:+ | gene-YMR186W_AKU4011 | rna-NM_001182692.1_AKU4011 | cds-NP_013911.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:280178-282310:- | gene-YMR186W_BG1 | rna-NM_001182692.1_BG1 | cds-NP_013911.1_BG1 | 96.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:616502-618634:+ | gene-YMR186W_Bruggeman | rna-NM_001182692.1_Bruggeman | cds-NP_013911.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:619247-621613:+ | gene-YMR186W_CAT1 | rna-NM_001182692.1_CAT1 | cds-NP_013911.1_CAT1 | 87.7 | 99.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:604543-606660:+ | gene-YMR186W_CBS1585 | rna-NM_001182692.1_CBS1585 | cds-NP_013911.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:608806-610923:+ | gene-YMR186W_CBS436 | rna-NM_001182692.1_CBS436 | cds-NP_013911.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:716102-718219:+ | gene-YMR186W_CBS6412 | rna-NM_001182692.1_CBS6412 | cds-NP_013911.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:603692-605809:+ | gene-YMR186W_CBS6413 | rna-NM_001182692.1_CBS6413 | cds-NP_013911.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:626934-629085:+ | gene-YMR186W_CENPK1137D | rna-NM_001182692.1_CENPK1137D | cds-NP_013911.1_CENPK1137D | 96.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:664732-666849:+ | gene-YMR186W_EthanolRed | rna-NM_001182692.1_EthanolRed | cds-NP_013911.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:610388-612505:+ | gene-YMR186W_FaliES1 | rna-NM_001182692.1_FaliES1 | cds-NP_013911.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000265.1:1-673:- | gene-YMR186W_JAY291 | rna-NM_001182692.1_JAY291 | cds-NP_013911.1_JAY291 | 31.7 | 31.7 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:610048-612180:+ | gene-YMR186W_MUCL30387 | rna-NM_001182692.1_MUCL30387 | cds-NP_013911.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:616828-618960:+ | gene-YMR186W_MUCL30388 | rna-NM_001182692.1_MUCL30388 | cds-NP_013911.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:605615-607732:+ | gene-YMR186W_MUCL39482 | rna-NM_001182692.1_MUCL39482 | cds-NP_013911.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:612947-615079:+ | gene-YMR186W_MUCL42920 | rna-NM_001182692.1_MUCL42920 | cds-NP_013911.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:632309-634426:+ | gene-YMR186W_NCIM3186 | rna-NM_001182692.1_NCIM3186 | cds-NP_013911.1_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:605267-607384:+ | gene-YMR186W_NCYC1407 | rna-NM_001182692.1_NCYC1407 | cds-NP_013911.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:615135-617267:+ | gene-YMR186W_PE2H3 | rna-NM_001182692.1_PE2H3 | cds-NP_013911.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:616121-618253:+ | gene-YMR186W_PE2H4 | rna-NM_001182692.1_PE2H4 | cds-NP_013911.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:632355-634472:+ | gene-YMR186W_S288C | rna-NM_001182692.1_S288C | cds-NP_013911.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:173628-175760:- | gene-YMR186W_SA1 | rna-NM_001182692.1_SA1 | cds-NP_013911.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:606514-608631:+ | gene-YMR186W_ThermosaccDry | rna-NM_001182692.1_ThermosaccDry | cds-NP_013911.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:619683-621800:+ | gene-YMR186W_VR1 | rna-NM_001182692.1_VR1 | cds-NP_013911.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:22302-24419:+ | gene-YMR186W_ZTW1 | rna-NM_001182692.1_ZTW1 | cds-NP_013911.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:624414-626546:+ | gene-YMR186W_Sparadoxus | rna-NM_001182692.1_Sparadoxus | cds-NP_013911.1_Sparadoxus | 93.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |