Gene name: HRT1
Reference locus (S288C): YOL133W
Gene biotype: protein_coding
Description: RING-box protein HRT1; RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair; Belongs to the RING-box family
Top 10 interactors (score): DCN1 (0.999); RTT101 (0.999); CUL3 (0.999); CDC34 (0.999); UBC12 (0.999); CDC53 (0.999); CDC4 (0.999); SKP1 (0.999); ELC1 (0.999); RRI1 (0.998); APC11 (0.997); MET30 (0.992); GRR1 (0.99); UBA3 (0.988); UBC5 (0.981); UBC7 (0.981); UBC4 (0.978); ELA1 (0.975); MMS1 (0.967); RUB1 (0.956)
Homologues (species, bitscore): RBX1 (Homo sapiens, 139.4); Rbx1 (Mus musculus, 139.4); rbx1 (Danio rerio, 140.6); rnf7 (Xenopus tropicalis, 90.1); Roc1a (Drosophila melanogaster, 128.6); rbx-1 (Caenorhabditis elegans, 137.9); AT3G42830 (Arabidopsis thaliana, 135.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:58983-59348:+ | gene-YOL133W_AKU4011 | rna-NM_001183387.1_AKU4011 | cds-NP_014508.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:24604-24969:+ | gene-YOL133W_BG1 | rna-NM_001183387.1_BG1 | cds-NP_014508.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:60260-60625:+ | gene-YOL133W_Bruggeman | rna-NM_001183387.1_Bruggeman | cds-NP_014508.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:59218-59583:+ | gene-YOL133W_CAT1 | rna-NM_001183387.1_CAT1 | cds-NP_014508.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:53459-53824:+ | gene-YOL133W_CBS1585 | rna-NM_001183387.1_CBS1585 | cds-NP_014508.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:59305-59670:+ | gene-YOL133W_CBS436 | rna-NM_001183387.1_CBS436 | cds-NP_014508.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:53323-53688:+ | gene-YOL133W_CBS6412 | rna-NM_001183387.1_CBS6412 | cds-NP_014508.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:59791-60156:+ | gene-YOL133W_CBS6413 | rna-NM_001183387.1_CBS6413 | cds-NP_014508.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:70220-70585:+ | gene-YOL133W_CENPK1137D | rna-NM_001183387.1_CENPK1137D | cds-NP_014508.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:57235-57600:+ | gene-YOL133W_EthanolRed | rna-NM_001183387.1_EthanolRed | cds-NP_014508.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:59264-59629:+ | gene-YOL133W_FaliES1 | rna-NM_001183387.1_FaliES1 | cds-NP_014508.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000329.1:22922-23287:- | gene-YOL133W_JAY291 | rna-NM_001183387.1_JAY291 | cds-NP_014508.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:64900-65265:+ | gene-YOL133W_MUCL30387 | rna-NM_001183387.1_MUCL30387 | cds-NP_014508.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:67894-68259:+ | gene-YOL133W_MUCL30388 | rna-NM_001183387.1_MUCL30388 | cds-NP_014508.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:61394-61759:+ | gene-YOL133W_MUCL39482 | rna-NM_001183387.1_MUCL39482 | cds-NP_014508.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:77280-77645:+ | gene-YOL133W_MUCL42920 | rna-NM_001183387.1_MUCL42920 | cds-NP_014508.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:70214-70579:+ | gene-YOL133W_NCIM3186 | rna-NM_001183387.1_NCIM3186 | cds-NP_014508.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:67433-67798:+ | gene-YOL133W_NCYC1407 | rna-NM_001183387.1_NCYC1407 | cds-NP_014508.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:45863-46228:+ | gene-YOL133W_PE2H3 | rna-NM_001183387.1_PE2H3 | cds-NP_014508.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:62811-63176:+ | gene-YOL133W_PE2H4 | rna-NM_001183387.1_PE2H4 | cds-NP_014508.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:70325-70690:+ | gene-YOL133W_S288C | rna-NM_001183387.1_S288C | cds-NP_014508.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:43755-44120:+ | gene-YOL133W_SA1 | rna-NM_001183387.1_SA1 | cds-NP_014508.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:58402-58767:+ | gene-YOL133W_ThermosaccDry | rna-NM_001183387.1_ThermosaccDry | cds-NP_014508.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:59061-59426:+ | gene-YOL133W_VR1 | rna-NM_001183387.1_VR1 | cds-NP_014508.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:58156-58521:+ | gene-YOL133W_ZTW1 | rna-NM_001183387.1_ZTW1 | cds-NP_014508.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:60625-60990:+ | gene-YOL133W_Sparadoxus | rna-NM_001183387.1_Sparadoxus | cds-NP_014508.1_Sparadoxus | 93.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |