Gene name: HRD3
Reference locus (S288C): YLR207W
Gene biotype: protein_coding
Description: ERAD-associated E3 ubiquitin-protein ligase component HRD3; ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events; Belongs to the sel-1 family
Top 10 interactors (score): YOS9 (0.999); HRD1 (0.999); USA1 (0.999); CDC48 (0.999); DER1 (0.999); KAR2 (0.999); UBX2 (0.999); UBC7 (0.997); NPL4 (0.997); SSM4 (0.996); UFD1 (0.995); CUE1 (0.993); MNL1 (0.98); SEC61 (0.98); PRC1 (0.933); DFM1 (0.929); FKH1 (0.92); YUR1 (0.918); HMG2 (0.881); IRE1 (0.876)
Homologues (species, bitscore): SEL1L (Homo sapiens, 118.6); Sel1l (Mus musculus, 114.4); sel1l (Danio rerio, 110.9); sel1l (Xenopus tropicalis, 103.2); Hrd3 (Drosophila melanogaster, 116.3); sel-1 (Caenorhabditis elegans, 97.1); EBS5 (Arabidopsis thaliana, 96.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:510941-513442:+ | gene-YLR207W_AKU4011 | rna-NM_001182094.1_AKU4011 | cds-NP_013308.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000177.1:68180-70687:+ | gene-YLR207W_BG1 | rna-NM_001182094.1_BG1 | cds-NP_013308.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:551165-553666:+ | gene-YLR207W_Bruggeman | rna-NM_001182094.1_Bruggeman | cds-NP_013308.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:550797-553304:+ | gene-YLR207W_CAT1 | rna-NM_001182094.1_CAT1 | cds-NP_013308.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:546433-548934:+ | gene-YLR207W_CBS1585 | rna-NM_001182094.1_CBS1585 | cds-NP_013308.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:536618-539128:+ | gene-YLR207W_CBS436 | rna-NM_001182094.1_CBS436 | cds-NP_013308.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:514995-517496:+ | gene-YLR207W_CBS6412 | rna-NM_001182094.1_CBS6412 | cds-NP_013308.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:546730-549231:+ | gene-YLR207W_CBS6413 | rna-NM_001182094.1_CBS6413 | cds-NP_013308.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:541433-543934:+ | gene-YLR207W_CENPK1137D | rna-NM_001182094.1_CENPK1137D | cds-NP_013308.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:510443-512944:+ | gene-YLR207W_EthanolRed | rna-NM_001182094.1_EthanolRed | cds-NP_013308.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:539370-541871:+ | gene-YLR207W_FaliES1 | rna-NM_001182094.1_FaliES1 | cds-NP_013308.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000004.1:66273-68779:+ | gene-YLR207W_JAY291 | rna-NM_001182094.1_JAY291 | cds-NP_013308.1_JAY291 | 99.1 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:551216-553717:+ | gene-YLR207W_MUCL30387 | rna-NM_001182094.1_MUCL30387 | cds-NP_013308.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:556154-558655:+ | gene-YLR207W_MUCL30388 | rna-NM_001182094.1_MUCL30388 | cds-NP_013308.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:547416-549917:+ | gene-YLR207W_MUCL39482 | rna-NM_001182094.1_MUCL39482 | cds-NP_013308.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:547920-550421:+ | gene-YLR207W_MUCL42920 | rna-NM_001182094.1_MUCL42920 | cds-NP_013308.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:556762-559263:+ | gene-YLR207W_NCIM3186 | rna-NM_001182094.1_NCIM3186 | cds-NP_013308.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:539835-542336:+ | gene-YLR207W_NCYC1407 | rna-NM_001182094.1_NCYC1407 | cds-NP_013308.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:544073-546580:+ | gene-YLR207W_PE2H3 | rna-NM_001182094.1_PE2H3 | cds-NP_013308.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:543817-546324:+ | gene-YLR207W_PE2H4 | rna-NM_001182094.1_PE2H4 | cds-NP_013308.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:556788-559289:+ | gene-YLR207W_S288C | rna-NM_001182094.1_S288C | cds-NP_013308.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000042.1:66316-68823:+ | gene-YLR207W_SA1 | rna-NM_001182094.1_SA1 | cds-NP_013308.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:541873-544374:+ | gene-YLR207W_ThermosaccDry | rna-NM_001182094.1_ThermosaccDry | cds-NP_013308.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:553208-555715:+ | gene-YLR207W_VR1 | rna-NM_001182094.1_VR1 | cds-NP_013308.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:66154-68658:+ | gene-YLR207W_ZTW1 | rna-NM_001182094.1_ZTW1 | cds-NP_013308.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:527972-530467:+ | gene-YLR207W_Sparadoxus | rna-NM_001182094.1_Sparadoxus | cds-NP_013308.1_Sparadoxus | 89.6 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |