Gene name: HRD1
Reference locus (S288C): YOL013C
Gene biotype: protein_coding
Description: ERAD-associated E3 ubiquitin-protein ligase HRD1; Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon; Belongs to the HRD1 family
Top 10 interactors (score): HRD3 (0.999); UBC7 (0.999); UBX2 (0.999); DER1 (0.999); NPL4 (0.999); USA1 (0.999); CDC48 (0.999); SSM4 (0.999); YOS9 (0.999); UFD1 (0.998); CUE1 (0.994); SEC61 (0.993); KAR2 (0.983); MNL1 (0.979); HMG2 (0.979); IRE1 (0.978); PRC1 (0.956); UBC1 (0.948); PDI1 (0.94); DFM1 (0.929)
Homologues (species, bitscore): SYVN1 (Homo sapiens, 114.8); Syvn1 (Mus musculus, 114.4); syvn1 (Danio rerio, 115.5); syvn1 (Xenopus tropicalis, 110.5); sip3 (Drosophila melanogaster, 99.4); sel-11 (Caenorhabditis elegans, 97.1); Hrd1B (Arabidopsis thaliana, 85.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:285756-287411:- | gene-YOL013C_AKU4011 | rna-NM_001183267.1_AKU4011 | cds-NP_014630.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:101342-102997:- | gene-YOL013C_BG1 | rna-NM_001183267.1_BG1 | cds-NP_014630.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:288573-290228:- | gene-YOL013C_Bruggeman | rna-NM_001183267.1_Bruggeman | cds-NP_014630.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:286712-288367:- | gene-YOL013C_CAT1 | rna-NM_001183267.1_CAT1 | cds-NP_014630.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:280433-282088:- | gene-YOL013C_CBS1585 | rna-NM_001183267.1_CBS1585 | cds-NP_014630.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:284674-286329:- | gene-YOL013C_CBS436 | rna-NM_001183267.1_CBS436 | cds-NP_014630.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:279783-281438:- | gene-YOL013C_CBS6412 | rna-NM_001183267.1_CBS6412 | cds-NP_014630.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:287316-288971:- | gene-YOL013C_CBS6413 | rna-NM_001183267.1_CBS6413 | cds-NP_014630.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:301135-302790:- | gene-YOL013C_CENPK1137D | rna-NM_001183267.1_CENPK1137D | cds-NP_014630.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:282568-284223:- | gene-YOL013C_EthanolRed | rna-NM_001183267.1_EthanolRed | cds-NP_014630.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:285895-287550:- | gene-YOL013C_FaliES1 | rna-NM_001183267.1_FaliES1 | cds-NP_014630.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000015.1:41736-43391:+ | gene-YOL013C_JAY291 | rna-NM_001183267.1_JAY291 | cds-NP_014630.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:292771-294426:- | gene-YOL013C_MUCL30387 | rna-NM_001183267.1_MUCL30387 | cds-NP_014630.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:296217-297872:- | gene-YOL013C_MUCL30388 | rna-NM_001183267.1_MUCL30388 | cds-NP_014630.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:287916-289571:- | gene-YOL013C_MUCL39482 | rna-NM_001183267.1_MUCL39482 | cds-NP_014630.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:302830-304485:- | gene-YOL013C_MUCL42920 | rna-NM_001183267.1_MUCL42920 | cds-NP_014630.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:301269-302924:- | gene-YOL013C_NCIM3186 | rna-NM_001183267.1_NCIM3186 | cds-NP_014630.1_NCIM3186 | 98.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:294649-296304:- | gene-YOL013C_NCYC1407 | rna-NM_001183267.1_NCYC1407 | cds-NP_014630.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:289263-290918:- | gene-YOL013C_PE2H3 | rna-NM_001183267.1_PE2H3 | cds-NP_014630.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:299662-301317:- | gene-YOL013C_PE2H4 | rna-NM_001183267.1_PE2H4 | cds-NP_014630.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:301380-303035:- | gene-YOL013C_S288C | rna-NM_001183267.1_S288C | cds-NP_014630.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:269362-271017:- | gene-YOL013C_SA1 | rna-NM_001183267.1_SA1 | cds-NP_014630.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:284466-286121:- | gene-YOL013C_ThermosaccDry | rna-NM_001183267.1_ThermosaccDry | cds-NP_014630.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:285225-286880:- | gene-YOL013C_VR1 | rna-NM_001183267.1_VR1 | cds-NP_014630.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:19137-20792:- | gene-YOL013C_ZTW1 | rna-NM_001183267.1_ZTW1 | cds-NP_014630.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:292776-294410:- | gene-YOL013C_Sparadoxus | rna-NM_001183267.1_Sparadoxus | cds-NP_014630.1_Sparadoxus | 88.7 | 98.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |