Gene name: HOS2
Reference locus (S288C): YGL194C
Gene biotype: protein_coding
Description: Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
Top 10 interactors (score): SNT1 (0.999); SIF2 (0.999); SIN3 (0.999); PHO23 (0.998); SET3 (0.997); HAT2 (0.997); CPR1 (0.996); HOS4 (0.996); HOS3 (0.992); HDA1 (0.989); HST1 (0.988); EAF3 (0.986); RCO1 (0.981); HTZ1 (0.977); RPD3 (0.974); SDS3 (0.966); SET2 (0.963); UBC9 (0.956); CTI6 (0.949); UME6 (0.945)
Homologues (species, bitscore): HDAC3 (Homo sapiens, 447.6); Hdac3 (Mus musculus, 447.2); hdac3 (Danio rerio, 446.4); hdac3 (Xenopus tropicalis, 448.0); Hdac3 (Drosophila melanogaster, 450.7); hda-1 (Caenorhabditis elegans, 409.1); HDA9 (Arabidopsis thaliana, 449.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:142904-144262:- | gene-YGL194C_AKU4011 | rna-NM_001181059.1_AKU4011 | cds-NP_011321.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:266176-267534:+ | gene-YGL194C_BG1 | rna-NM_001181059.1_BG1 | cds-NP_011321.1_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:145147-146505:- | gene-YGL194C_Bruggeman | rna-NM_001181059.1_Bruggeman | cds-NP_011321.1_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:140761-142119:- | gene-YGL194C_CAT1 | rna-NM_001181059.1_CAT1 | cds-NP_011321.1_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:146043-147401:- | gene-YGL194C_CBS1585 | rna-NM_001181059.1_CBS1585 | cds-NP_011321.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:141028-142386:- | gene-YGL194C_CBS436 | rna-NM_001181059.1_CBS436 | cds-NP_011321.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:132821-134179:- | gene-YGL194C_CBS6412 | rna-NM_001181059.1_CBS6412 | cds-NP_011321.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:140355-141713:- | gene-YGL194C_CBS6413 | rna-NM_001181059.1_CBS6413 | cds-NP_011321.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:140569-141927:- | gene-YGL194C_CENPK1137D | rna-NM_001181059.1_CENPK1137D | cds-NP_011321.1_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:132887-134245:- | gene-YGL194C_EthanolRed | rna-NM_001181059.1_EthanolRed | cds-NP_011321.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:133887-135245:- | gene-YGL194C_FaliES1 | rna-NM_001181059.1_FaliES1 | cds-NP_011321.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000397.1:59219-60577:- | gene-YGL194C_JAY291 | rna-NM_001181059.1_JAY291 | cds-NP_011321.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:142384-143742:- | gene-YGL194C_MUCL30387 | rna-NM_001181059.1_MUCL30387 | cds-NP_011321.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:144709-146067:- | gene-YGL194C_MUCL30388 | rna-NM_001181059.1_MUCL30388 | cds-NP_011321.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:143053-144411:- | gene-YGL194C_MUCL39482 | rna-NM_001181059.1_MUCL39482 | cds-NP_011321.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:145689-147047:- | gene-YGL194C_MUCL42920 | rna-NM_001181059.1_MUCL42920 | cds-NP_011321.1_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:140368-141726:- | gene-YGL194C_NCIM3186 | rna-NM_001181059.1_NCIM3186 | cds-NP_011321.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:134535-135893:- | gene-YGL194C_NCYC1407 | rna-NM_001181059.1_NCYC1407 | cds-NP_011321.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:136531-137889:- | gene-YGL194C_PE2H3 | rna-NM_001181059.1_PE2H3 | cds-NP_011321.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:136079-137437:- | gene-YGL194C_PE2H4 | rna-NM_001181059.1_PE2H4 | cds-NP_011321.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:140368-141726:- | gene-YGL194C_S288C | rna-NM_001181059.1_S288C | cds-NP_011321.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000067.1:132-1490:- | gene-YGL194C_SA1 | rna-NM_001181059.1_SA1 | cds-NP_011321.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:134149-135507:- | gene-YGL194C_ThermosaccDry | rna-NM_001181059.1_ThermosaccDry | cds-NP_011321.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:141435-142793:- | gene-YGL194C_VR1 | rna-NM_001181059.1_VR1 | cds-NP_011321.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:132685-134043:- | gene-YGL194C_ZTW1 | rna-NM_001181059.1_ZTW1 | cds-NP_011321.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:139559-140917:- | gene-YGL194C_Sparadoxus | rna-NM_001181059.1_Sparadoxus | cds-NP_011321.1_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |