Gene name: HMG2
Reference locus (S288C): YLR450W
Gene biotype: protein_coding
Description: HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant
Top 10 interactors (score): HMG1 (0.999); ERG13 (0.996); ERG12 (0.994); ERG1 (0.982); HRD1 (0.979); ERG11 (0.975); ERG25 (0.953); IDI1 (0.952); MVD1 (0.938); ERG20 (0.932); UBC7 (0.928); ERG9 (0.924); CDC48 (0.917); ERG10 (0.909); ERG8 (0.892); HRD3 (0.881); NSG1 (0.858); BTS1 (0.817); UFD1 (0.777); ERG7 (0.767)
Homologues (species, bitscore): HMGCR (Homo sapiens, 511.5); Hmgcr (Mus musculus, 515.4); hmgcra (Danio rerio, 525.8); hmgcr (Xenopus tropicalis, 408.7); Hmgcr (Drosophila melanogaster, 454.5); hmgr-1 (Caenorhabditis elegans, 368.6); HMG1 (Arabidopsis thaliana, 476.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:970918-974055:+ | gene-YLR450W_AKU4011 | rna-NM_001182338.1_AKU4011 | cds-NP_013555.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:203354-206491:+ | gene-YLR450W_BG1 | rna-NM_001182338.1_BG1 | cds-NP_013555.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:1009211-1012348:+ | gene-YLR450W_Bruggeman | rna-NM_001182338.1_Bruggeman | cds-NP_013555.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:1005219-1008356:+ | gene-YLR450W_CAT1 | rna-NM_001182338.1_CAT1 | cds-NP_013555.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:1006508-1009645:+ | gene-YLR450W_CBS1585 | rna-NM_001182338.1_CBS1585 | cds-NP_013555.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:995833-998970:+ | gene-YLR450W_CBS436 | rna-NM_001182338.1_CBS436 | cds-NP_013555.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:1042537-1045674:+ | gene-YLR450W_CBS6412 | rna-NM_001182338.1_CBS6412 | cds-NP_013555.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:1007278-1010415:+ | gene-YLR450W_CBS6413 | rna-NM_001182338.1_CBS6413 | cds-NP_013555.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:1017233-1020370:+ | gene-YLR450W_CENPK1137D | rna-NM_001182338.1_CENPK1137D | cds-NP_013555.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:963934-967071:+ | gene-YLR450W_EthanolRed | rna-NM_001182338.1_EthanolRed | cds-NP_013555.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:999205-1002342:+ | gene-YLR450W_FaliES1 | rna-NM_001182338.1_FaliES1 | cds-NP_013555.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000194.1:16335-19472:- | gene-YLR450W_JAY291 | rna-NM_001182338.1_JAY291 | cds-NP_013555.1_JAY291 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:1008069-1011206:+ | gene-YLR450W_MUCL30387 | rna-NM_001182338.1_MUCL30387 | cds-NP_013555.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:1017902-1021039:+ | gene-YLR450W_MUCL30388 | rna-NM_001182338.1_MUCL30388 | cds-NP_013555.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:1007742-1010879:+ | gene-YLR450W_MUCL39482 | rna-NM_001182338.1_MUCL39482 | cds-NP_013555.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:1008193-1011330:+ | gene-YLR450W_MUCL42920 | rna-NM_001182338.1_MUCL42920 | cds-NP_013555.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:1032601-1035738:+ | gene-YLR450W_NCIM3186 | rna-NM_001182338.1_NCIM3186 | cds-NP_013555.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:1017179-1020316:+ | gene-YLR450W_NCYC1407 | rna-NM_001182338.1_NCYC1407 | cds-NP_013555.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:1003623-1006760:+ | gene-YLR450W_PE2H3 | rna-NM_001182338.1_PE2H3 | cds-NP_013555.1_PE2H3 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:1003367-1006504:+ | gene-YLR450W_PE2H4 | rna-NM_001182338.1_PE2H4 | cds-NP_013555.1_PE2H4 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:1032627-1035764:+ | gene-YLR450W_S288C | rna-NM_001182338.1_S288C | cds-NP_013555.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:24098-27235:- | gene-YLR450W_SA1 | rna-NM_001182338.1_SA1 | cds-NP_013555.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:1002283-1005420:+ | gene-YLR450W_ThermosaccDry | rna-NM_001182338.1_ThermosaccDry | cds-NP_013555.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:1008704-1011841:+ | gene-YLR450W_VR1 | rna-NM_001182338.1_VR1 | cds-NP_013555.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:332537-335674:+ | gene-YLR450W_ZTW1 | rna-NM_001182338.1_ZTW1 | cds-NP_013555.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:981478-984616:+ | gene-YLR450W_Sparadoxus | rna-NM_001182338.1_Sparadoxus | cds-NP_013555.1_Sparadoxus | 90.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |