Gene name: HMG1
Reference locus (S288C): YML075C
Gene biotype: protein_coding
Description: HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant
Top 10 interactors (score): HMG2 (0.999); ERG13 (0.998); ERG12 (0.995); ERG1 (0.988); ERG11 (0.987); ERG25 (0.979); ERG20 (0.978); IDI1 (0.971); ERG9 (0.966); BTS1 (0.947); MVD1 (0.941); ERG10 (0.932); ERG8 (0.92); ERG7 (0.901); ERG5 (0.879); ERG26 (0.831); ERG3 (0.816); OLE1 (0.812); ERG6 (0.805); ERG2 (0.777)
Homologues (species, bitscore): HMGCR (Homo sapiens, 523.5); Hmgcr (Mus musculus, 527.3); hmgcra (Danio rerio, 538.5); hmgcr (Xenopus tropicalis, 411.8); Hmgcr (Drosophila melanogaster, 471.5); hmgr-1 (Caenorhabditis elegans, 370.9); HMG1 (Arabidopsis thaliana, 481.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:109467-112631:- | gene-YML075C_AKU4011 | rna-NM_001182434.1_AKU4011 | cds-NP_013636.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:363481-366645:+ | gene-YML075C_BG1 | rna-NM_001182434.1_BG1 | cds-NP_013636.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:115636-118800:- | gene-YML075C_Bruggeman | rna-NM_001182434.1_Bruggeman | cds-NP_013636.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:117310-120474:- | gene-YML075C_CAT1 | rna-NM_001182434.1_CAT1 | cds-NP_013636.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:109476-112640:- | gene-YML075C_CBS1585 | rna-NM_001182434.1_CBS1585 | cds-NP_013636.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:115404-118568:- | gene-YML075C_CBS436 | rna-NM_001182434.1_CBS436 | cds-NP_013636.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:110184-113348:- | gene-YML075C_CBS6412 | rna-NM_001182434.1_CBS6412 | cds-NP_013636.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:108659-111823:- | gene-YML075C_CBS6413 | rna-NM_001182434.1_CBS6413 | cds-NP_013636.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:110454-113618:- | gene-YML075C_CENPK1137D | rna-NM_001182434.1_CENPK1137D | cds-NP_013636.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:109742-112906:- | gene-YML075C_EthanolRed | rna-NM_001182434.1_EthanolRed | cds-NP_013636.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:110249-113413:- | gene-YML075C_FaliES1 | rna-NM_001182434.1_FaliES1 | cds-NP_013636.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000366.1:43671-46835:+ | gene-YML075C_JAY291 | rna-NM_001182434.1_JAY291 | cds-NP_013636.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:114160-117324:- | gene-YML075C_MUCL30387 | rna-NM_001182434.1_MUCL30387 | cds-NP_013636.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:117306-120470:- | gene-YML075C_MUCL30388 | rna-NM_001182434.1_MUCL30388 | cds-NP_013636.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:109487-112651:- | gene-YML075C_MUCL39482 | rna-NM_001182434.1_MUCL39482 | cds-NP_013636.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:114214-117378:- | gene-YML075C_MUCL42920 | rna-NM_001182434.1_MUCL42920 | cds-NP_013636.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:115688-118852:- | gene-YML075C_NCIM3186 | rna-NM_001182434.1_NCIM3186 | cds-NP_013636.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:110282-113446:- | gene-YML075C_NCYC1407 | rna-NM_001182434.1_NCYC1407 | cds-NP_013636.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:115639-118803:- | gene-YML075C_PE2H3 | rna-NM_001182434.1_PE2H3 | cds-NP_013636.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:115581-118745:- | gene-YML075C_PE2H4 | rna-NM_001182434.1_PE2H4 | cds-NP_013636.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:115734-118898:- | gene-YML075C_S288C | rna-NM_001182434.1_S288C | cds-NP_013636.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000041.1:65339-68503:+ | gene-YML075C_SA1 | rna-NM_001182434.1_SA1 | cds-NP_013636.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:109541-112705:- | gene-YML075C_ThermosaccDry | rna-NM_001182434.1_ThermosaccDry | cds-NP_013636.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:113929-117093:- | gene-YML075C_VR1 | rna-NM_001182434.1_VR1 | cds-NP_013636.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:89076-92240:- | gene-YML075C_ZTW1 | rna-NM_001182434.1_ZTW1 | cds-NP_013636.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:120260-123427:- | gene-YML075C_Sparadoxus | rna-NM_001182434.1_Sparadoxus | cds-NP_013636.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |