Gene name: HKR1
Reference locus (S288C): YDR420W
Gene biotype: protein_coding
Description: Signaling mucin HKR1; Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; Belongs to the HKR1/MSB2 family
Top 10 interactors (score): SHO1 (0.977); OPY2 (0.96); CDC42 (0.947); MSB2 (0.917); SLN1 (0.895); PBS2 (0.894); STE50 (0.863); STE11 (0.861); AHK1 (0.859); HOG1 (0.833); STE20 (0.814); YPD1 (0.814); SSK1 (0.813); PTP2 (0.811); SSK2 (0.779); SSK22 (0.747); PTP3 (0.717); CLA4 (0.671); KSS1 (0.619); FPS1 (0.612)
Homologues (species, bitscore): AI607873 (Mus musculus, 60.1); Muc55B (Drosophila melanogaster, 88.2); Y53C10A.10 (Caenorhabditis elegans, 68.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1246400-1251941:+ | gene-YDR420W_AKU4011 | rna-NM_001180728.1_AKU4011 | cds-NP_010708.1_AKU4011 | 93.8 | 99.2 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:124906-130282:+ | gene-YDR420W_BG1 | rna-NM_001180728.1_BG1 | cds-NP_010708.1_BG1 | 94.3 | 98.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1277302-1282332:+ | gene-YDR420W_Bruggeman | rna-NM_001180728.1_Bruggeman | cds-NP_010708.1_Bruggeman | 91.9 | 93.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1255862-1260526:+ | gene-YDR420W_CAT1 | rna-NM_001180728.1_CAT1 | cds-NP_010708.1_CAT1 | 86.0 | 86.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1241320-1246270:+ | gene-YDR420W_CBS1585 | rna-NM_001180728.1_CBS1585 | cds-NP_010708.1_CBS1585 | 90.2 | 91.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1260199-1265606:+ | gene-YDR420W_CBS436 | rna-NM_001180728.1_CBS436 | cds-NP_010708.1_CBS436 | 91.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1237374-1242236:+ | gene-YDR420W_CBS6412 | rna-NM_001180728.1_CBS6412 | cds-NP_010708.1_CBS6412 | 88.7 | 89.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1259229-1264385:+ | gene-YDR420W_CBS6413 | rna-NM_001180728.1_CBS6413 | cds-NP_010708.1_CBS6413 | 93.8 | 95.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1304925-1310342:+ | gene-YDR420W_CENPK1137D | rna-NM_001180728.1_CENPK1137D | cds-NP_010708.1_CENPK1137D | 69.6 | 82.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1250788-1255524:+ | gene-YDR420W_EthanolRed | rna-NM_001180728.1_EthanolRed | cds-NP_010708.1_EthanolRed | 86.5 | 87.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1254095-1258831:+ | gene-YDR420W_FaliES1 | rna-NM_001180728.1_FaliES1 | cds-NP_010708.1_FaliES1 | 86.5 | 87.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000263.1:1-3109:+ | gene-YDR420W_JAY291 | rna-NM_001180728.1_JAY291 | cds-NP_010708.1_JAY291 | 57.4 | 57.4 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1260863-1265973:+ | gene-YDR420W_MUCL30387 | rna-NM_001180728.1_MUCL30387 | cds-NP_010708.1_MUCL30387 | 91.4 | 94.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1242970-1247910:+ | gene-YDR420W_MUCL30388 | rna-NM_001180728.1_MUCL30388 | cds-NP_010708.1_MUCL30388 | 90.0 | 91.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1232648-1237762:+ | gene-YDR420W_MUCL39482 | rna-NM_001180728.1_MUCL39482 | cds-NP_010708.1_MUCL39482 | 92.5 | 94.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1175348-1180165:+ | gene-YDR420W_MUCL42920 | rna-NM_001180728.1_MUCL42920 | cds-NP_010708.1_MUCL42920 | 86.9 | 88.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1306190-1311598:+ | gene-YDR420W_NCIM3186 | rna-NM_001180728.1_NCIM3186 | cds-NP_010708.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1246620-1251526:+ | gene-YDR420W_NCYC1407 | rna-NM_001180728.1_NCYC1407 | cds-NP_010708.1_NCYC1407 | 89.3 | 90.6 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1256775-1262351:+ | gene-YDR420W_PE2H3 | rna-NM_001180728.1_PE2H3 | cds-NP_010708.1_PE2H3 | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1262343-1267919:+ | gene-YDR420W_PE2H4 | rna-NM_001180728.1_PE2H4 | cds-NP_010708.1_PE2H4 | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1306267-1311675:+ | gene-YDR420W_S288C | rna-NM_001180728.1_S288C | cds-NP_010708.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000082.1:45546-48757:- | gene-YDR420W_SA1 | rna-NM_001180728.1_SA1 | cds-NP_010708.1_SA1 | 59.3 | 59.3 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1258357-1263093:+ | gene-YDR420W_ThermosaccDry | rna-NM_001180728.1_ThermosaccDry | cds-NP_010708.1_ThermosaccDry | 86.5 | 87.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1273579-1278313:+ | gene-YDR420W_VR1 | rna-NM_001180728.1_VR1 | cds-NP_010708.1_VR1 | 87.4 | 87.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:301170-305738:+ | gene-YDR420W_ZTW1 | rna-NM_001180728.1_ZTW1 | cds-NP_010708.1_ZTW1 | 84.1 | 84.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1254321-1259381:+ | gene-YDR420W_Sparadoxus | rna-NM_001180728.1_Sparadoxus | cds-NP_010708.1_Sparadoxus | 73.2 | 91.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |